Clinicopathological factors related to cervical lymph node metastasis in a patient with carcinoma of the oral floor

Suzuki, Michitaka; Suzuki, Toyoaki; Asai, Masao; Ichimura, Keiichi; Nibu, Ken‐ichi; Sugasawa, Masashi; Kaga, Kimitaka

doi:10.1080/03655230701600020

Cited by 20 publications

(20 citation statements)

References 19 publications

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“…23Y25 Vascular and perineural invasion apparently correlates with higher probability of regional and distant metastasis and lower 5-year survival rates in OSCC. 15,26 Oral cancers with muscular invasion have poor prognosis. 27 In this study, most cases show low TATE in 3 different areas.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Andisheh-Tadbir¹,

Ashraf²,

Sardari³

2009

Journal of Craniofacial Surgery

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Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Andisheh-Tadbir¹,

Ashraf²,

Sardari³

2009

Journal of Craniofacial Surgery

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“…These multiparametric grading schemes have been shown to be prognostically significant, but have failed to find favour in routine diagnostic practice, owing to their complexity. The individual component that is most strongly predictive of outcome in these grading systems is the POI at the deep aspect of the tumour . The RCPath has consequently incorporated assessment of the POI in their guidelines for the reporting of oral cavity SCC, using a simplified two‐tier classification system.…”

Section: Discussionmentioning

confidence: 99%

Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

et al. 2016

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“…Vascular invasion has been significantly correlated with cancers of the floor of the mouth (Suzuki et al 2007), but there is a lack of information with respect to vascular invasion and LSCC. In this cohort, presence of vascular invasion ( p = 0.0009) was a predictor of poor survival.…”

Section: Discussionmentioning

confidence: 99%

DNA hypermethylation markers of poor outcome in laryngeal cancer

et al. 2010

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This study examined molecular (DNA hypermethylation), clinical, histopathological, demographical, smoking, and alcohol variables to assess diagnosis (early versus late stage) and prognosis (survival) outcomes in a retrospective primary laryngeal squamous cell carcinoma (LSCC) cohort. The study cohort of 79 primary LSCC was drawn from a multi-ethnic (37% African American), primary care patient population, diagnosed by surgical biopsies in the Henry Ford Health System from 1991 to 2004 and followed from 5 to 18 years (through 2009). Of the 41 variables, univariate risk factors of p < 0.10 were tested in multivariate models (logistic regression (diagnosis) and Cox (survival) models (p < 0.05)). Aberrant methylation of estrogen receptor 1 (ESR1; p = 0.01), race as African American (p = 0.04), and tumor necrosis (extensive; p = 0.02) were independent predictors of late stage LSCC. Independent predictors of poor survival included presence of vascular invasion (p = 0.0009), late stage disease (p = 0.03), and methylation of the hypermethylated in cancer 1 (HIC1) gene (p = 0.0002). Aberrant methylation of ESR1 and HIC1 signified independent markers of poorer outcome. In this multi-ethnic, primary LSCC cohort, race remained a predictor of late stage disease supporting disparate diagnosis outcomes for African American patients with LSCC.

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Clinicopathological factors related to cervical lymph node metastasis in a patient with carcinoma of the oral floor

Cited by 20 publications

References 19 publications

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

DNA hypermethylation markers of poor outcome in laryngeal cancer

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