Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Abstract

Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.

Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study

“…Oliviera et al [8] reported equivalent 5-year and 10-year overall survival and disease-free survival rates for both OSCC with intense and absent/mild tissue eosinophilia. Likewise, Tadbir et al [24] concluded that TATE has no correlation with prognostic parameter in OSCC. Leighton et al [6] assessed the presence of TATE in nasopharyngeal carcinoma and found that TATE was not significantly associated with local recurrence, distant metastasis, and survival.…”

“…Alkhabuli and High [31] did not find any correlation between eosinophil density and SCC differentiation in cases of SCC of tongue. Similarly, Tadbir et al [24] failed to report any significant correlation between TATE and tumor differentiation in patients of OSCC. Also, Rahrotaban et al [25] demonstrated no significant correlation between TATE and histopathologic grading, but it was lower in poorly differentiated group than in others in cases of HNSCC.…”

“…It has been related to a favourable and [7, 10, 19, 20] to an unfavourable [15, 21] prognosis or even having no influence on patient outcome [6, 24]. …”

Eosinophils and Oral Squamous Cell Carcinoma: A Short Review

“…Tumour-associated tissue eosinophilia (TATE) has been reported in diverse sites [14, 35, 47–53] including the head and neck region [6, 7, 54–65] (Figure 2). …”

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

“…Recently, eosinophilia has been investigated in head and neck carcinomas, especially the oral cavity carcinomas [7][8][9][10][11]. Although it has been shown that the relationship between eosinophil count and prognosis is statistically significant, it still remains controversial [12][13][14][15].…”