Clinicopathological factors relating malignant lymphomawith sjögren's syndrome

Anaya, Juan Manuel; McGuff, H. Stan; Banks, Peter M.; Talal, Norman

doi:10.1016/s0049-0172(96)80019-9

Cited by 120 publications

(77 citation statements)

References 44 publications

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“…As for malignant lymphoma in Sjogren's syndrome, a high incidence of B cell lymphoma as well as monoclonal gammopathy has been recognized. Low grade B cell lymphomas in Sjogren's syndrome are frequently observed, including follicular lymphoma and MALTlymphoma (4). Recently the association between antecedent autoimmune diseases and lymphoproliferative disorders has been reported (2).…”

Section: Case Reportmentioning

confidence: 99%

Pulmonary MALT Lymphoma with Amyloid Production in a Patient with Primary Sioegren's Syndrome.

et al. 2002

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A 53-year-old womanwasadmitted to our hospital complaining of cough, low grade fever, chest pain and sicca symptoms. A chest radiograph showed an abnormal shadow and chest computed tomography revealed a tumor in left S6. She was diagnosed as Sjogren's syndrome by sialography and histological findings of labial biopsy. The surgically resected tumor specimen showed proliferation of lymphoid cells with lymphoepithelial lesions, which were positive for CD20 and kappa light chain. Kappa light chainpositive amyloid was found within the tumor. The tumor showed rearranged kappa light chain genes. The diagnosis was pulmonary mucosa associated lymphoid tissue lymphoma with amyloid production. (Internal Medicine 41 : 309-311, 2002)

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Section: Case Reportmentioning

confidence: 99%

Pulmonary MALT Lymphoma with Amyloid Production in a Patient with Primary Sioegren's Syndrome.

et al. 2002

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“…Malignant lymphomas develop in less than 10% of patients (1). One of the features of the SS salivary gland is an elevated expression of HLA-DR antigens on the salivary epithelial cells (2,3).…”

mentioning

confidence: 99%

Involvement of the interferon‐γ–induced T cell–attracting chemokines, interferon‐γ–inducible 10‐kd protein (CXCL10) and monokine induced by interferon‐γ (CXCL9), in the salivary gland lesions of patients with Sjögren's syndrome

Ogawa

et al. 2002

Arthritis & Rheumatism

199

147

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Objective. To elucidate the mechanism of the development of T cell infiltrates in the salivary glands of patients with Sjögren's syndrome (SS), we studied T cell-attracting chemokines and their receptors.Methods. The expression of the T cell-attracting chemokines, interferon-␥ (IFN␥)-inducible 10-kd protein (IP-10; also called CXCL10), monokine induced by IFN␥ (Mig; also called CXCL9), and stromal cellderived factor 1 (SDF-1; also called CXCL12), in salivary glands from SS patients was investigated by polymerase chain reaction-enzyme-linked immunosorbent assay (ELISA). Cells that produce chemokines and lymphocytes that express chemokine receptors were identified by immunohistochemistry. The production of IP-10 and Mig proteins by salivary epithelial cells in response to IFN␥ was determined by ELISA.Results. Expression of IP-10 and Mig messenger RNA (mRNA) was significantly up-regulated in SS salivary glands compared with normal salivary glands (both P < 0.01). There was no significant difference in SDF-1 mRNA expression between the SS and normal salivary glands. IP-10 and Mig proteins were predominantly expressed in the ductal epithelium adjacent to lymphoid infiltrates. Most of the CD3؉ infiltrating lymphocytes in dense periductal foci expressed CXCR3, the receptor for IP-10 and Mig. IFN␥ induced the production of high levels of IP-10 and Mig proteins from cultured SS salivary epithelial cells.Conclusion. These findings suggest that IFN␥ stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the SS salivary gland. Chemokines or chemokine receptors could be a rational new therapeutic target in SS.

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“…Lymphoma risk seems to increase with disease severity, expressed by decreased levels of serum immunoglobulins, high serum β2-microglobulin levels and disappearance of a previous positive rheumatoid factor (FR) (Anderson & Talal, 1972, Anaya et al, 1996; parotid gland enlargement, splenomegaly, lymphadenopathy (Kassan et al, 1978); low C4 levels and palpable purpura (Ioannidis et al, 2002, Skopouli et al, 2000; MMC (Tzioufas et al, 1996). A higher relative risk of developing lymphoproliferative disorders in patients with an early onset of disease has been suggested, with a significant and independent association between lymphoma development and low C4 levels (Ramos-Casals et al, 2005).…”

Section: Risk Factorsmentioning

confidence: 99%