Clinicopathological features and prognosis of triple negative breast cancer in Kuwait: A comparative/perspective analysis

Fayaz, Mohammed S.; El-Sherify, Mustafa; Elbasmy, Amany; Zlouf, Sadeq A.; Nazmy, Nashwa; George, Thomas J.; Samir, Susan; Attia, G.; Eissa, Heba El-Sayed

doi:10.1016/j.rpor.2013.08.007

Cited by 18 publications

(18 citation statements)

References 75 publications

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“…Some said that TNBC is commonly found in younger age, but some is older age. 3,8,9 Compared to literatures mentioned above, this study results had the youngest mean age of TNBC. These different results might be occurred because of different races and lifestyle from the patients that lived in the countries.…”

Section: Resultsmentioning

confidence: 46%

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Leo¹,

Delyuzar²,

Betty³

2018

IJCTR

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Nowadays, breast cancer has been known as heterogenous disease with various biological features which require different therapy strategies. Breast cancers with lack or no expression of estrogen (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER-2) are defined as triple negative breast cancer (TNBC). To date, Ki-67 has been used in order to characterize cell proliferation. This study is to analyze Ki-67 labeling index (LI) expression based on clinicopathological features of TNBC. This descriptive study with cross-sectional design was performed. Data about demographics were extracted from patients' medical record and histopathologic feature and immunohistochemistry was done. Results of analysis data were presented in frequency tables. Mean and standard deviation Ki-67 LI were also obtained. In this study, most patients aged 35-49 years old with mean of 46,8 years old. Most of them had bigger tumour size, had already metastasized to lymph node, had no distant metastases and higher stage. Ki-67 LI value in this study quite high with mean of 43,89%. %. If TNBC patients were young, had distant metastases, higher mitotic count (≥15/10 HPF) and higher grade, they tended to have higher Ki-67 LI. Patients with metaplastic carcinoma of no special type and carcinoma with medullary features also tended to have higher Ki-67 LI. Meanwhile tumour size, metastases to lymph node and clinical stage were not in accordance with Ki-67 LI.

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Section: Resultsmentioning

confidence: 46%

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Leo¹,

Delyuzar²,

Betty³

2018

IJCTR

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“…Therefore, more care needs to be taken when selecting patients with the ER+/HER2− or HER2+ subtypes for breast‐conserving surgery. Although patients with the TNBC subtype generally have a poor prognosis, more concentric shrinkage was observed in patients after NAC in this study. This suggests that it may be feasible for these patients to receive breast‐conserving surgery after shrinkage of the primary tumor.…”

Section: Discussionmentioning

confidence: 46%

Magnetic resonance imaging patterns of tumor regression in breast cancer patients after neo-adjuvant chemotherapy, and an analysis of the influencing factors

Shao

et al. 2017

Breast J

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The objective of this study was to analyze the patterns of breast tumor shrinkage in patients after neo-adjuvant chemotherapy (NAC) based on magnetic resonance imaging (MRI), and to evaluate the influential factors. Preoperative breast dynamic contrast-enhanced MRI was performed on 88 patients before NAC, every 2 weeks during their chemotherapy treatment, and the week before their surgery. The MRI enhancement pattern of the primary tumors was classified into one of four categories based on BI-RADS-MRI: type I (postcontrast mass image), II (multiple small masses image), III (postcontrast mass image with peripheral non-mass enhancement image), and IV (nonmass enhancement image). Multivariate regression and χ test analyses were employed to establish significant associations. Two kinds of tumor regression patterns were observed: concentric shrinkage was observed in 39 lesions of 88 patients (44.3%), and nests or dendritic shrinkage was observed for the other 49 lesions (55.7%). ER+/HER2-, HER2+, and type I lesions were observed in 23 (62.2%), 21 (63.6%), and 29 (60.0%) patients, respectively, out of 49 nest or dendritic shrinkage pattern lesions. Triple negative breast cancer lesions, and type II, III, and IV lesions were observed in 13 (72.2%), 9 (81.8%), 10 (62.5%), and 10 (76.9%) patients, respectively, out of 39 lesions with a concentric shrinkage pattern. Molecular subtypes (χ =7.171, P<.05) and the MRI schedule of enhancement (χ =11.244, P<.05) were significantly associated with the tumor regression patterns. Multivariate analysis showed molecular subtypes (P<.05) and MRI pattern enhancement (P<.05) were significant predictive factors. Molecular subtypes and the MRI enhancement patterns of the primary tumors were significant predictive factors for tumor regression patterns of breast cancer after NAC.

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“…60% of the pt were Premenopausal which is comparable to the study done in Turkey [70%], 11 and 48% in Lebanon In our study 16.6 % patients gave history of oral contraceptives [OCP] as compared by 72% in Kwan et. al 18 , 44 % in Kuwait 33 , 55 % in Phipps et al study 19 and 35 % in the Turkish study. 11 In our study 10 % patients gave history of smoking as compared by 7.7 % in Kuwait 33 and 49 % in Kwan et al In TNBC more than 90 % exhibit an invasive ductal histology [IDC].…”

Section: Discussionmentioning

confidence: 84%

“…al 18 , 44 % in Kuwait 33 , 55 % in Phipps et al study 19 and 35 % in the Turkish study. 11 In our study 10 % patients gave history of smoking as compared by 7.7 % in Kuwait 33 and 49 % in Kwan et al In TNBC more than 90 % exhibit an invasive ductal histology [IDC]. In our study, 96.6% pts were of IDC which is almost comparable to that of Singapore and Japan [93 % and 95 % respectively].…”

Section: Discussionmentioning

confidence: 84%

Clinicopathological Features of Triple Negative Breast Cancer: A Perspective Analysis

Jain¹,

Jeengar²,

Agrawal³

et al. 2017

IOSR JDMS

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Clinicopathological features and prognosis of triple negative breast cancer in Kuwait: A comparative/perspective analysis

Cited by 18 publications

References 75 publications

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Ki-67 Labeling Index Based on Clinicopathological Characteristics in Triple Negative Breast Carcinoma (TNBC)

Magnetic resonance imaging patterns of tumor regression in breast cancer patients after neo-adjuvant chemotherapy, and an analysis of the influencing factors

Clinicopathological Features of Triple Negative Breast Cancer: A Perspective Analysis

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