Clinicopathological features of bladder cancer associated with chronic exposure to arsenic

Chow, Nan Hua; Guo, Yue-Liang Leon; Lin, Johnny Shinn Nan; Su, Jian; Tzai, Tzong-Shin; Guo, How‐Ran; Su, Ih‐Jen

doi:10.1038/bjc.1997.291

Cited by 12 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Guo et al (2001a) reported significantly increased rate differences for bladder cancer in men and women in Taiwan exposed to 0.64 mg arsenic/L in the drinking water, but not at lower exposure levels. The arsenic-induced bladder tumors do not appear to be histologically different than similar bladder tumor types of nonarsenic origin (Chow et al 1997), although they tended to be more pronounced. In contrast, Michaud et al (2004) reported no correlation between arsenic levels in toenails and the incidence of bladder cancers in Finnish workers.…”

Section: Health Effectsmentioning

confidence: 59%

Toxicological profile for arsenic

Chou¹,

Harper²

2007

348

View full text Add to dashboard Cite

show abstract

Section: Health Effectsmentioning

confidence: 59%

Toxicological profile for arsenic

Chou¹,

Harper²

2007

348

View full text Add to dashboard Cite

show abstract

“…31 The findings that urothelial carcinoma from BFD area has a higher rate of DNA aneuploidy, 9 histological anaplasia, 10 and unusual p53 mutational spectra 11 appear to support the promoter role of arsenic in the development of urinary tract carcinoma, although the molecular mechanisms underlying the pathogenesis of human cancer remain to be elucidated.…”

Section: Discussionmentioning

confidence: 90%

“…First, our prior cohort study found that bladder cancer from the BFD-endemic area had a significantly higher incidence of histological anaplasia, especially bizarre giant cells, compared with nonendemic controls. 10 Second, the clear cell differentiation was suggested to be one of the early histological changes of malignant transformation of the liver. 16 …”

Section: Study Variablesmentioning

confidence: 99%

“…9 A significantly higher histological grading was demonstrated in a pathoepidemiological survey on bladder tumors from BFD-endemic areas compared with controls, although no apparent difference of recurrence rate or longterm survival was observed. 10 Further support for the distinct nature of bladder cancer from BFD-endemic areas comes from mutational screening of p53 gene showing CGC to CAC base changes at codon 175, a mutational hotspot associated with inflammatory agents, and double mutations in some tumors. 11 Both of these mutations are relatively rare in human cancer, suggesting that epithelial cancer related to chronic arsenic exposure may have distinct pathobiologic features compared with sporadic cases.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of Hepatocellular Carcinoma in a High Arsenicism Area in Taiwan: A Case???Control Study

Chow

et al. 2004

Journal of Occupational and Environmental Medicine

View full text Add to dashboard Cite

Arsenic contamination of drinking water is noticeably linked to the occurrence of skin, bladder, lung cancers, and hepatocellular carcinoma (HCC). Blackfoot disease (BFD) caused by arsenicosis is endemic in southwestern Taiwan, where artesian well water contains high concentrations of arsenic, and mortality from HCC shows a dose-response increase by concentration of arsenic in the well water. This case-control study was conducted to examine the clinical characteristics of HCC patients of BFD-endemic area. A total of 65 HCC cases (54 men and 11 women) were recruited from the BFD-endemic areas. The clinicopathological features were compared with 130 age- and sex-matched HCC control patients from non-BFD-endemic areas. Characteristics analyzed included hepatitis viral infection status, hepatitis activity, liver function, histological findings, computed tomography scan characteristics, and patient survival. No differences were observed between HCC patients or their tumors, from study and control areas.

show abstract

“…Immunohistopathological studies showed that arsenic-induced bladder tumors were pathobiologically and prognostically identical to non-arsenical bladder tumors (143). At the cytological level, it was found that level of arsenic exposure was directly correlated with the induction of chromosomal instability and that tumors from arsenic exposed individuals might behave much more aggressively than bladder tumors of non-exposed individuals (144,145).…”

Section: Arsenic-induced Non-dermatological Cancersmentioning

confidence: 99%

Arsenic-induced Cancers: A Review with Special Reference to Gene, Environment and Their Interaction

Banerjee

Bhattacharjee

Giri

2011

Genes and Environment

View full text Add to dashboard Cite

Chronic exposure to the toxic metalloid arsenic, either through occupational or environmental route results in the development of a plethora of dermatological as well as non-dermatological health eŠects, multi-organ cancers being the most severe ones. Several epidemiological studies have reported the occurrence of diŠerent types of cancers in populations exposed chronically to arsenic from diŠerent corners of the globe, but the spectrum of symptoms and severity vary widely. Several genetic and environmental factors might play an important causal role for such observed diŠerences, including genetic polymorphisms, dietary habits and socioeconomic status of the population. Unfortunately, the paradoxical nature of this carcinogen makes the use of animal model systems unsuitable, since they do not re‰ect the exact in vivo condition of arsenic exposure in human beings. Hence, in this present review, we have attempted to collate the isolated pieces of information available in existing literature depicting the various forms of arsenic-induced cancers, variations and etiology thereof. We have attempted to depict the entire spectrum of carcinogenic outcomes of chronic arsenic exposure and the interactions among several components like, genes (polymorphisms and mutations), environmental factors and dietary factors in the process. The literature reviews are primarily based on the human beings (in vivo), but to understand the underlying mechanism, we have also collated the information based on cell line models, and animal models where human data is scanty or unavailable. Thus, here we present a comprehensive review on the current state of research in theˆeld of arsenic-induced cancer and explore the underlying mechanism of arsenic-induced carcinogenicity, along with relevant historical perspective.

show abstract

Clinicopathological features of bladder cancer associated with chronic exposure to arsenic

Cited by 12 publications

References 10 publications

Toxicological profile for arsenic

Toxicological profile for arsenic

Characteristics of Hepatocellular Carcinoma in a High Arsenicism Area in Taiwan: A Case???Control Study

Arsenic-induced Cancers: A Review with Special Reference to Gene, Environment and Their Interaction

Contact Info

Product

Resources

About