Clinicopathological features of recurrent papillary thyroid cancer

Abstract

BackgroundTo investigate the clinicopathological features of recurrent papillary thyroid carcinoma (PTC).MethodsA retrospective analysis on clinical and pathological data of 34 patients with recurrent PTC was carried out. A total of 281 patients with non-recurrent PTC during the same time period were chosen as the control group.ResultsPatients were divided into three groups according to the pathological subtype. The number of patients belonging to Groups 1, 2, and 3 were 28, 154, and 133, respectively. 78 patients underwent partial or whole thyroidectomy, 151 cases underwent thyroidectomy combining neck regional lymph node dissection, and 86 patients underwent thyroidectomy combining modified or radical neck dissection. Univariate analysis showed that PTC recurrence was associated with tumor size, extrathyroid invasion, initial surgery approach, lymph node metastasis, and pathological subtype (P < 0.05). Patient age, gender, complication with Hashimoto's thyroiditis, and multifocality were unrelated to PTC recurrence (P > 0.05). Multivariate analysis showed that initial surgery approach and pathological subtype perform important functions in PTC recurrence (P < 0.001). Initial surgery approach presented a negative correlation with PTC recurrence (β = −0.320, OR = 0.726). The pathological subtype was also related to PTC recurrence (β = 0.923, OR = 2.517).ConclusionPTC patients without neck dissection showed greater likelihood of postoperative recurrence. Patients with the tall cell, columnar cell, diffuse sclerosing, and oncocytic variants showed a higher propensity for PTC recurrence after operation compared with those who did not. Tumor volume, extrathyroid invasion, and multiple lymph node metastases at the time of initial operation were also significantly related to postoperative recurrence. Follow-up supervision must be enhanced after initial treatment to mitigate PTC recurrence in susceptible patients. Effective and standard treatments must be adopted immediately after the discovery of recurrence.

Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

“…The main characteristics of the 71 articles included in this meta-analysis are summarized in Table 1 [ 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 ]. A total of 44,034 participants with PTC were enrolled, of whom 11,132 (25.3%) had HT.…”

Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma

“…Recurrent PTC mainly refers to local and distant recurrence, including recurrence of primary tumor, lymph node metastases, invasion of the esophagus and trachea, invasion of muscles, nerves and distant metastases. Many factors could affect the recurrence of thyroid cancer, and 20% PTC patients relapse after treatment and require reoperation (7)(8)(9). Consequently, analyzing the molecular characteristics of PTC and exploring new targets for therapy have been major clinical concerns.…”

In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma

“…Research indicated that the most invasive variants of PTC are: diffuse sclerosis variant (DSV), tall cell variant (TCV), columnar cell variant (CCV), solid variant (SV), and hobnail variant (HV). These variants are generally closely related to higher recurrence and metastasis rates and have low sensitivity to chemotherapy and radioactive iodine therapy, and the survival rate may also be low [1] [25] [33] [35]- [41]. Finally, we compared the biological characteristics of tumor cells in primary thyroid carcinoma and lymph node metastasis.…”