Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma

Garzino-Demo, Paolo; Dell’Acqua, Alessandro; Dalmasso, Paola; Fasolis, Massimo; Terra, Marco H.; Ramieri, Guglielmo; Berrone, Sid; Rampino, Monica; Schena, Marina

doi:10.1016/j.jcms.2006.04.004

Cited by 116 publications

(77 citation statements)

References 34 publications

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“…It has been reported that OSCC cases associated to PVL develop commonly in these sites (Fig. 5), which are infrequent sites for lesions if compared to those of conventional OSCC cases in Western populations: tongue, floor of mouth and buccal mucosa (16,(18)(19)(20)(25)(26)(27)(28). The presence of this criterion makes the diagnosis of PVL highly doubtful.…”

Section: Discussionmentioning

confidence: 99%

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

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Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and nonsmokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.

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Section: Discussionmentioning

confidence: 99%

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

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“…This would be seen as a lack of significant difference in outcome between patients with adequate and inadequate margins. We speculate that the degree of margin ''inadequacy'' was underestimated in the studies by Chen, Loree, and Garzino, which is reflected as significantly poorer outcomes for these patients [28][29][30]. Testing this hypothesis requires a well-designed multicenter study, ideally limited to one anatomic site, which would be adequately powered to adjust for the many anticipated confounders.…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

“…Using the definition of ''tumor cut-through'' for positive margins, Byers [27] reported on 216 patients, and demonstrated local recurrence rates of 80% in the positive margin group, compared to 12-18% in the negative margin group. The definition of C5 mm for margin adequacy is a common standard, and was used in the following statistically significant studies [28][29][30][31]. Chen reported on 270 patients and demonstrated locoregional recurrence of 55 versus 17%, and 5-year disease-free survival of 7 versus 39%, for inadequate, versus negative margin groups, respectively [28].…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

“…Loree reported on 303 patients and demonstrated locoregional recurrence of 30 versus 18%, and 5-year overall survival of 52 versus 60%, for inadequate, versus negative margin groups, respectively [29]. Garzino [30] reported on 245 patients and demonstrated 5-year overall survival of 48 versus 65%, for inadequate, versus negative margin groups, respectively. El-Husseiny reported on 66 patients and demonstrated 5-year diseasefree survival of 0 versus 63%, and 5-year overall survival of 21% versus 72%, for adequate versus inadequate margin groups, respectively.…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

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Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

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“…The prognosis of this entity in the mouth is poor; the local invasion and cervical lymph node metastasis rates are high. 2,3 Even with advances in oncological therapy, the five-year survival rate for patients with invasive OSCCs remains low (about 35%). Such morbidity rates may be due to factors such as varied responses to chemotherapy and radiotherapy, late presentation and delayed diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Expressão da proteína nm23 em carcinoma de células escamosas de língua metastático e não-metastático

Silveira

Oliveira

Morais

et al. 2008

Rev. Bras. Otorrinolaringol.

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Oral squamous cells carcinoma (OSCC) shows unfavorable prognosis due to its invasion potential around the neighboring tissues and the elevated incidence of metastasis. Aim: the present paper aims at analyzing the immunohistochemical expression of the nm23 protein in metastatic and non-metastatic SCCs of tongue. Methods: the immuno-expression to the nm23-hl protein was diagnosed in 35 tongue SCC (15 of which exhibiting metastasis). Nm23-hl immuno-scores were assigned as follow: score 0 = absent, 1 = focal and 2 = diffuse expression. Results: The Fisher's exact test was performed and there was no statistical difference between the nm23-hl immuno-scores and the tongue SCCs studied cases (p=0.365), although 66.7% of metastatic cases presented negative nm23-hl expression. Conclusions: Protein nm23 was not associated with a positiveness for tongue SCC without metastasis. Thus, several others factors inherent to host and malignancy can be associated with the mechanisms that suppress the metastatic process in this disease.

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Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma

Cited by 116 publications

References 34 publications

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Expressão da proteína nm23 em carcinoma de células escamosas de língua metastático e não-metastático

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