Clinicopathological review of tubercular laryngitis in 32 cases of pulmonary Kochs

Bhat, Vikram Kemmannu; Latha, P. Swarna; Upadhya, Divya; Hegde, Jyotirmay S

doi:10.1016/j.amjoto.2008.07.005

Cited by 18 publications

(16 citation statements)

References 12 publications

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“…The higher frequency of cough found in our study may be related to a greater concomitance of LTB with pulmonary TB, different from others, where the frequency of this symptom was smaller, probably because they had a higher percent of isolated LTB [ 20 , 25 , 30 , 31 ]. The association between cough and bilateral lesions shows that this symptom is related to a more extensive larynx involvement, probably triggering afferent stimuli in a greater number of cough receptors of this organ.…”

Section: Discussioncontrasting

confidence: 99%

“…Similarly, the highest percentages of concomitant involvement of more than one larynx anatomic structure and bilateral involvement of this organ in the present study can be related to the prevalence of pulmonary TB, as previously suggested [ 10 , 20 ]. The classic involvement of the posterior portion of the larynx due to accumulation of infected secretion in bedridden patients, although still observed [ 7 , 15 , 31 ], is no longer a cardinal sign of LTB as it was in the past [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis

Reis

Costa

et al. 2016

PLoS ONE

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IntroductionLaryngeal tuberculosis (LTB) is the most frequent granulomatous disease of the larynx and represents less than 2% of extrapulmonary TB cases. There are no pathognomonic clinical and endoscopic features of this disease and studies on LTB that can assist in its diagnostic characterization are lacking.ObjectiveTo identify factors associated with clinical and topographical features of LTB.Methoda retrospective cross-sectional study was conducted from the medical records of 36 patients with confirmed LTB diagnosis.ResultsDysphonia and cough were the main symptoms presented by patients and the true vocal folds the most frequently affected site. The average of the duration of the disease evolution was significantly higher in patients with dysphonia than in patients without this symptom. We observed association between dysphonia and true vocal fold lesions and between odynophagia and lesions in the epiglottis, arytenoids and aryepiglottic folds. Odynophagia was more frequent in individuals with lesions in four or more laryngeal sites. Weight loss equal or above 10% of the body weight was more frequent in patients with odynophagia as first symptom and in patients with ulcerated lesion. Dyspnea on exertion was more frequent in individuals with more extensive laryngeal lesions. The percentage of smokers with lesions in four or more laryngeal sites was greater than that found in non-smokers. Laryngeal tissue fragment bacilloscopy and culture examinations were less positive than sputum ones.ConclusionsSmoking appears to be associated with the development of more extensive LTB lesions, and LTB with dyspnea on exertion and odynophagia with consequent impairment of nutritional status. We emphasize the need for histopathologic confirmation, once positive sputum bacteriological examinations seem not to necessarily reflect laryngeal involvement.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis

Reis

Costa

et al. 2016

PLoS ONE

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“…A study by Auerbach found that 698 (92.3%) of 700 autopsied cases of laryngeal tuberculosis had advanced pulmonary tuberculosis [1]. While it has been reported that primary laryngeal tuberculosis has been increasing in recent years [8,13,20], the majority of cases show positive findings on X-rays in not only our study but also in others [14,19,21]. Those studies support that bronchogenic route is the main cause of infection.…”

Section: Image Diagnosis and Sputum Examinationsupporting

confidence: 82%

Laryngeal tuberculosis: A report of 17 cases

Kurokawa¹,

Nibu²,

Ichimura³

et al. 2015

Auris Nasus Larynx

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“…Patients with laryngeal and tracheobronchial (Fig. 4) TB may have Mtb in sputum despite a normal chest X-ray, although in general, the radiograph will suggest the possible diagnosis (Bhat et al 2009).…”

Section: Postprimary Pulmonary Tbmentioning

confidence: 99%

Clinical Aspects of Adult Tuberculosis

Loddenkemper

Lipman

Zumla

2015

Cold Spring Harb Perspect Med

103

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Tuberculosis (TB) in adults can present in a large number of ways. The lung is the predominant site of TB. Primary pulmonary TB should be distinguished from postprimary pulmonary TB, which is the most frequent TB manifestation in adults (70%-80% cases). Cough is common, although the chest radiograph often raises suspicion of disease. Sputum sampling is a key step in the diagnosis of TB, and invasive procedures such as bronchoscopy may be necessary to achieve adequate samples for diagnosis. Extrapulmonary involvement, which may present many years after exposure, occurs in a variable proportion of cases (20%-45%). This reflects the country of origin of patients and also the frequency of associated human immunodeficiency virus (HIV) coinfection. In the latter case, the presentation of TB is often nonspecific, and care needs to be taken to not miss the diagnosis. Anti-TB therapy should be given in line with proven (or assumed) drug resistance. In extrapulmonary TB, adjunctive therapeutic measures may be indicated; although in all cases, support is often required to ensure that people are able to complete treatment with minimal adverse events and maximal adherence to the prescribed regimen, and so reduce risk of future disease for themselves and others.

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Clinicopathological review of tubercular laryngitis in 32 cases of pulmonary Kochs

Cited by 18 publications

References 12 publications

Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis

Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis

Laryngeal tuberculosis: A report of 17 cases

Clinical Aspects of Adult Tuberculosis

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