Clinicopathological significance of steroidogenic factor-1 expression in ovarian cancer versus ovarian sex cord stromal tumor

Hu, Zhuoying; Tang, Liangdan; Zhang, Hongyu; Niu, Jingya; Lou, Meng

doi:10.1007/s13277-014-2187-3

Cited by 4 publications

(5 citation statements)

References 55 publications

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“…It encodes a human steroidogenic factor 1-protein (hSF1) that is involved in gonad development in both males and females [29]. hSF1 expression has been found to be significantly lower in ovarian cancer than in normal ovarian tissue [30] and mutations in NR5A1 are associated with primary ovarian insufficiency [31]. The third upstream regulator identified in our analysis was FOXA2, that has demonstrated favorable prognosis based on TCGA data [32] and was predicted to regulate six genes that were downregulated in omental samples vs primary tumor ( DLK1, GATA4, MAFA, MYOCD, NR1H4 and WNT5).…”

Section: Discussionmentioning

confidence: 99%

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

et al. 2019

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BackgroundHigh grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the optimal cytoreductive surgery and chemotherapy most patients develop chemoresistance, and the 5-year overall survival being only 25–35%.MethodsHere we analyzed the gene expression profiles of 10 primary HGSOC tumors and 10 related omental metastases using RNA sequencing and identified 100 differentially expressed genes.ResultsThe differentially expressed genes were associated with decreased embryogenesis and vasculogenesis and increased cellular proliferation and organismal death. Top upstream regulators responsible for this gene signature were NR5A1, GATA4, FOXL2, TP53 and BMP7. A subset of these genes were highly expressed in the ovarian cancer among the cancer transcriptomes of The Cancer Genome Atlas. Importantly, the metastatic gene signature was suggestive of poor survival in TCGA data based on gene enrichment analysis.ConclusionBy comparing the gene expression profiles of primary HGSOC tumors and their matched metastasis, we provide evidence that a signature of 100 genes is able to separate these two sample types and potentially predict patient survival. Our study identifies functional categories of genes and transcription factors that could play important roles in promoting metastases and serve as markers for cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

et al. 2019

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“…Conversely, clinical studies have suggested that ovarian tumors with functioning stroma secrete estradiol via the regulation of aromatase (CYP19), due to overexpression of SF-1 (103). A recent extensive meta-analysis of a wide range of ovarian cancer clinical studies was aimed at determining whether SF-1 is associated with ovarian tumor progression (115).…”

Section: Cancermentioning

confidence: 99%

The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction

Meinsohn

Smith

Bertolin

et al. 2019

Physiological Reviews

104

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Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogenic factor-1 (NR5A1, also known as SF-1) and liver receptor homolog-1 (NR5A2, also known as LRH-1), bind to the same DNA sequences, with different and nonoverlapping effects on targets. Endogenous regulation of both is achieved predominantly by cofactor interactions. SF-1 is expressed primarily in steroidogenic tissues, LRH-1 in tissues of endodermal origin and the gonads. Both receptors modulate cholesterol homeostasis, steroidogenesis, tissue-specific cell proliferation, and stem cell pluripotency. LRH-1 is essential for development beyond gastrulation and SF-1 for genesis of the adrenal, sexual differentiation, and Leydig cell function. Ovary-specific depletion of SF-1 disrupts follicle development, while LRH-1 depletion prevents ovulation, cumulus expansion, and luteinization. Uterine depletion of LRH-1 compromises decidualization and pregnancy. In humans, SF-1 is present in endometriotic tissue, where it regulates estrogen synthesis. SF-1 is underexpressed in ovarian cancer cells and overexpressed in Leydig cell tumors. In breast cancer cells, proliferation, migration and invasion, and chemotherapy resistance are regulated by LRH-1. In conclusion, the NR5A orphan nuclear receptors are nonredundant factors that are crucial regulators of a panoply of biological processes, across multiple reproductive tissues.

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“…19,20 While the aforementioned stains are helpful, this comes with a caveat since they can also be positive in sex cord-stromal tumors. 21,22 Hence, a known prior history sex cord-stromal tumor is crucial in the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Calretinin, which is a calcium‐binding protein, was first discovered in neural tissue and later found in adrenocortical cells, sex cord‐stromal cells, or mesothelial cells 19,20 . While the aforementioned stains are helpful, this comes with a caveat since they can also be positive in sex cord‐stromal tumors 21,22 . Hence, a known prior history sex cord‐stromal tumor is crucial in the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Ectopic adrenal cortical tissue presenting as gastrohepatic ligament “lymph node” diagnosed by fine‐needle aspiration: A case report

Policarpio‐Nicolas

2023

Diagnostic Cytopathology

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Ectopic adrenal cortical tissue has been reported in several locations, most often involving the retroperitoneal fat close to the adrenal gland. The reported cases presenting adjacent or proximal to the stomach are rare and mostly diagnosed on histology. To our knowledge, the cytologic features of ectopic adrenal cortical tissue diagnosed on fine needle aspiration are not well documented in the cytology literature. We describe the cytologic features of ectopic adrenal cortex which initially presented on imaging study as an enlarged gastrohepatic ligament “lymph node” on a patient with gastric signet ring cell carcinoma. The aspirates showed small clusters and cords of uniform cells with abundant vacuolated to densely compact cytoplasm, occasionally stripped nuclei, and delicate frayed cytoplasmic membranes dispersed in a bubbly, vacuolated background. Immunohistochemical stains performed on the corresponding cell block showed these cells were positive for SF‐1 and negative for PAX 8. The corresponding biopsy showed similar findings in addition to immunoreactivity to inhibin. Because the cytologic features of ectopic adrenal cortical tissue especially on unusual sites could easily mimic malignant neoplasms, familiarity with the cytologic features in conjunction with immunohistochemical stains are key in arriving at the correct diagnosis and avoiding misdiagnosis.

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Clinicopathological significance of steroidogenic factor-1 expression in ovarian cancer versus ovarian sex cord stromal tumor

Cited by 4 publications

References 55 publications

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction

Ectopic adrenal cortical tissue presenting as gastrohepatic ligament “lymph node” diagnosed by fine‐needle aspiration: A case report

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