Clinicopathological study of Multinodular goiter at AVBRH

Padmawar, Mangesh; Kher, Kiran Shrikant; Kakade, Anupam

doi:10.7439/ijbar.v5i1.557

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Out of 57 patients 35 underwent histopathological examination of which 28 cases (80%) were benign and 7 cases (20%) were malignant. 7 FNAC finding was significantly associated with Histopathological finding in detecting malignant or benign lesion of multinodular thyroid gland and diagnostic accuracy of FNAC is 92% (Table 12). Padmawar MR et al, studied the clinicopathological study of multinodular goitre at AVBRH.…”

Section: Discussionmentioning

confidence: 99%

“…All the 57 studied subjects underwent FNAC, out of which 51 cases (89.47%) turned out to be benign and 6 cases (10.52%) were malignant. 7 Total thyroidectomy was performed on 69 cases and 31 cases underwent hemithyroidectomy in the study group (Table 8). Kapoor S et al, studied the various presentation pattern of histomorphological changes of non -neoplastic and neoplastic lesions of the thyroid and their management.…”

Section: Discussionmentioning

confidence: 99%

“…Correlation of FNAC finding with histopathology finding showed 100% sensitivity, 93.33% specificity with 71.42% positive predictive value and 100% negative predictive value and diagnostic accuracy was 94.29%. 7 Ali et al, Thyroid Malignancy in Multinodular Goitre. FNAC confirmed the diagnosis of thyroid carcinoma in 81% of patients.…”

Section: Discussionmentioning

confidence: 99%

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A clinicopathological study of multinodular goitre

et al. 2019

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Background: Multinodular goitre (MNG) is a clinicopathological entity characterized by an increased volume of the thyroid gland with formation of nodules. The present study has been planned to study the various clinical presentations and diagnostic accuracy between operative findings and histopathological findings in a case of multinodular goitre.Methods: The present study was a hospital-based prospective study conducted in Dr D.Y. Patil Medical College, Hospital and Research Centre, Pune between July 2016 to September 2018. 100 patients aged between 15 to 75 yrs. clinically diagnosed as multinodular goitre were included.Results: FNAC finding of multinodular goitre in the study group showed colloid goitre was seen in 62 cases, 27 cases had multinodular goitre. 6 cases had neoplastic etiology, 3 cases had Hashimoto’s thyroiditis and 2 cases had papillary carcinoma of thyroid. HPE finding wise distribution showed that 10 cases were malignant, and 90 cases were benign. FNAC finding was significantly associated with histopathological finding in detecting malignant or benign lesion of multinodular thyroid gland and diagnostic accuracy of FNAC is 92%. Clinical finding comparison with operative finding showed that diagnostic accuracy of detecting malignant or benign lesion was only 35%. There was no significant difference among the two methods for detecting type of lesion in multinodular thyroid.Conclusions: Females are predominantly affected. About 8% cases of MNG are malignant. Considering the histopathological report as a gold standard, correlation of FNAC finding with histopathological finding was very much accurate and significant for detecting malignant and benign lesion of multinodular thyroid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A clinicopathological study of multinodular goitre

et al. 2019

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“…Anwar et al, reported 16.18% frequency of malignant tumors amongst multinodular goiters 10 , while Solomon et al, documented 18% prevalence of thyroid malignancy 6 . Padmawar et al, studied the clinicopathological correlation of Multinodular goiter and reported the frequencies of malignancy to be 20% on histopathological examination 11 . Nadeem et al, documented 14.9% incidence of malignancy in multinodular goiters 12 .…”

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confidence: 99%

Malignancy in Multinodular Goiter-Post Thyroidectomy: A Prospective Study

Naeem

Raza

Khan³

2021

PAFMJ

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Objective: To find out the frequency and types of malignancy in patients treated surgically for nontoxicmultinodular goiter and its correlation in different age groups and gender. Study Design: Cross-sectional study. Place and Duration of Study: Department of ENT, Combined Military Hospital Rawalpindi, from Dec 2018 toDec 2019. Methodology: A total of 116 patients operated for nontoxic multinodular goiter were included in the study.Demographic details along with pre-op Ultrasonography findings, Fine Needle Aspiration Cytology, thyroidfunction test results and post-op histopathological reports of the thyroid specimen were entered on pre-designed proforma. Results were analyzed using the Statistical Package for Social Sciences (SPSS) Version 22. Results: Age ranges from 19 to 70 years (mean 43.51 years). Out of 116 cases operated for multinodular goiter,37 (31.8%) had malignant thyroid lesions (13 males, 24 females). Papillary carcinoma of the thyroid (45.9%) wasthe commonest malignancy followed by a follicular variant of papillary carcinoma (24.3%). The most common age group with malignancies was 49-58 years. Conclusion: Malignant Thyroid cancers showed a female preponderance and were most common in age group49-58 years. Papillary carcinoma of thyroid was the commonest tumor. Radical thyroid surgery is a recommended surgical management option for nontoxic Multinodular goiter.

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“…A palpable solitary nodule represents a multinodular gland in about 35% of patients. [6] Nodular enlargement of thyroid is most often caused by nodular hyperplasia due to impaired synthesis of thyroid hormone. The degree of thyroid gland enlargement is proportional to the level and duration of thyroid hormone deficiency.…”

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A Retrospective Study on Thyroid Gland Lesions Associated With Multi-Nodular Goitre

Priya¹,

Cherian²

2017

jemds

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BACKGROUND Nodular enlargement of thyroid gland is a frequent surgical problem worldwide and it is most often caused by nodular hyperplasia due to impaired synthesis of thyroid hormone. An autonomous nodule may develop in 10% of long-standing multi-nodular goitre and produce hyperthyroidism. Sometimes nodular hyperplasia displays features that may be confused for a neoplastic process.The aim of this study is to find out the frequency of different types of non-neoplastic and neoplastic thyroid lesions developing in association with multi-nodular goitre. MATERIALS AND METHODSAll thyroidectomy specimens received in our Institution from January 2011 to December 2015 and which showed multi-nodular hyperplasia on histopathological examination were included. RESULT Nodular hyperplasia either alone or in combination with any other thyroid lesion was observed in 70.8% (n = 1529) of the total thyroidectomy specimens. Chronic lymphocytic thyroiditis was observed in 12.7% cases and important tumour-like thyroid lesions observed were cellular nodule (6.2%), Hurthle cell nodule (0.5%), papillary hyperplasia (0.5%) and pseudo-nuclear clearing (0.1%). Important thyroid neoplasms observed in association with multi-nodular goitre were Papillary carcinoma (3%), Hurthle cell adenoma (0.5%), Follicular adenoma (0.2%) and Medullary carcinoma (0.1%). Incidence rate of thyroid malignancy in association with nodular hyperplasia was 3.8%. CONCLUSIONMore than two-third of the neoplasms observed were papillary micro-carcinomas; this highlights the importance of thorough sampling of thyroidectomy specimens. However, comparatively thyroid neoplasms in nodular hyperplasia had a lower incidence rate in this study and the peak incidence of nodular hyperplasia associated papillary carcinoma was in younger age group. This difference may be attributed to improved public awareness and health welfare facilities available in Kerala.

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Clinicopathological study of Multinodular goiter at AVBRH

Cited by 8 publications

References 10 publications

A clinicopathological study of multinodular goitre

A clinicopathological study of multinodular goitre

Malignancy in Multinodular Goiter-Post Thyroidectomy: A Prospective Study

A Retrospective Study on Thyroid Gland Lesions Associated With Multi-Nodular Goitre

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