Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga &lt;i&gt;Halimeda macroloba&lt;/i&gt;

Dzeha, Thomas; Jaspars, Marcel; Tabudravu, Jioji N.

doi:10.4314/wiojms.v2i2.28436

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Alga hijau mempunyai kelimpahan yang sangat tinggi di Indonesia, terutama jenis Caulerpa sp., Halimeda sp., dan Ulva sp. Penelitian yang mengkaji potensi se-nyawa bioaktif makroalga dari suku Halimedaceae di antaranya adalah antimikrob dari Halimeda macroloba (Dzeha et al 2003) dan Halimeda opuntia (Mishra et al 2016). Ekstrak pigmen karotenoid H. discoidea mempunyai nilai IC50 = 99,65 ppm yang menunjukkan bahwa aktivitas antioksidan yang kuat (Agusti 2015).…”

Section: Pendahuluanunclassified

The Screening of Green Algae Halimeda opuntia (Linnaeus) as an Antioxidant from the Coast of West Aceh

Gazali

Nurjanah

Zamani

2019

JIPI

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Halimeda opuntia merupakan salah satu jenis alga hijau yang distribusinya cukup dominan di pesisir Barat Aceh. Penelitian ini bertujuan untuk menapis jenis alga hijau H. opuntia yang berpotensi sebagai agen antioksidan. Metode ekstraksi yang digunakan adalah maserasi tunggal. Pelarut yang digunakan ialah etanol (polar), etil asetat (semi polar), dan n-heksana (non-polar). Dengan ketiga pelarut tersebut diperoleh tiga ekstrak kasar, yaitu ekstrak etanol, ekstrak etil asetat, dan ekstrak n-heksana. Selanjutnya, ketiga ekstrak kasar tersebut digunakan untuk pengujian yang meliputi uji fitokimia dan aktivitas antioksidan dengan metode DPPH (2,2-Diphenyl-1-picrylhydrazyl). Hasil uji fitokimia menunjukkan bahwa ekstrak kasar etanol H. opuntia terdeteksi mengandung senyawa aktif berupa flavonoid, alkaloid, fenol, tanin, dan steroid. Sementara itu, ekstrak kasar etil asetat H. opuntia terdeteksi mengandung senyawa fenol. Kandungan total fenol ekstrak etanol H. opuntia = 2460,25 mg GAE/g dan ekstrak etil asetat = 972,68 mg GAE/g. Aktivitas antioksidan ekstrak etanol mempunyai nilai IC50 = 143,63 mg/L, sedangkan ekstrak etil asetat mempunyai nilai IC50 = 75,51 mg/L dengan Vitamin C sebagai kontrol positif. Hal ini menunjukkan bahwa ekstrak H. opuntia memiliki potensi vital sebagai agen antioksidan yang memberikan nilai tambah dalam industri farmasi.

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Section: Pendahuluanunclassified

The Screening of Green Algae Halimeda opuntia (Linnaeus) as an Antioxidant from the Coast of West Aceh

Gazali

Nurjanah

Zamani

2019

JIPI

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Free Phenolic Acids from the Seaweed Halimeda monile with Antioxidant Effect Protecting against Liver Injury

Mancini‐Filho

Novoa

González

et al. 2009

Zeitschrift Für Naturforschung C

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Phenolic compounds are found in seaweed species together with other substances presenting antioxidant activity. The objective of this work was to evaluate the antioxidant activity of the free phenolic acids (FPA) fraction from the seaweed Halimeda monile, and its activity to protect the expression of hepatic enzymes in rats, under experimental CCl4 injury. The antioxidant activity was measured by the DPPH method. The FPA fraction (80 mg/kg, p.o.) was administered during 20 consecutive days to rats. The peroxidation was performed by thiobarbituric acid reactive substances (TBARS). The SOD and CAT enzymatic expressions were measured by RT/PCR. The histology technique was used to evaluate liver injuries. The expression of both, CAT and SOD genes, was more preserved by FPA. Only partial injury could be observed by histology in the liver of rats receiving FPA as compared with the control group; and CCl4 administration induced 60% more peroxidation as compared with the rats receiving FPA. These data suggest that FPA could modulate the antioxidant enzymes and oxidative status in the liver through protection against adverse effects induced by chemical agents

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Alkaloid Caulerpin and Cytotoxic Activity against NCL-H460 Lung Cancer Cells Isolated along with β-sitosterol from the Halimeda cylindracea Decaisne

Dini¹,

Soekamto²,

Firdaus³

et al. 2021

JSM

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Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 µg/mL.

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Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga <i>Halimeda macroloba</i>

Cited by 5 publications

References 8 publications

The Screening of Green Algae Halimeda opuntia (Linnaeus) as an Antioxidant from the Coast of West Aceh

The Screening of Green Algae Halimeda opuntia (Linnaeus) as an Antioxidant from the Coast of West Aceh

Free Phenolic Acids from the Seaweed Halimeda monile with Antioxidant Effect Protecting against Liver Injury

Alkaloid Caulerpin and Cytotoxic Activity against NCL-H460 Lung Cancer Cells Isolated along with β-sitosterol from the Halimeda cylindracea Decaisne

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