CLIPPERS-Syndrom: Eine Erkrankung mit vielen Gesichtern – ein Fallbericht

Link, Tanja; Köcher, Stephanie Eva; Dohmen, Hildegard; Behr, Robert; Neumann‐Haefelin, Tobias

doi:10.1055/a-0874-2106

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…3,5 To find previous lymphoma-associated cases up to November 2023, PubMed and Scopus online databases were searched using the keywords "CLIPPER" and "Lymphoma". To the best of our knowledge, 20 patients with lymphoma-associated CLIPPERS have been reported [6][7][8][9][10][11][12][13][14][15][16] since the first introduction of CLIPPERS. 2 A review of 10 patients by Zhang et al showed that patients with lymphoma-associated CLIPPERS had worse clinical outcomes and higher risk of mortality compared to those without lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 5 To find previous lymphoma‐associated cases up to November 2023, PubMed and Scopus online databases were searched using the keywords “CLIPPER” and “Lymphoma”. To the best of our knowledge, 20 patients with lymphoma‐associated CLIPPERS have been reported 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 since the first introduction of CLIPPERS. 2 A review of 10 patients by Zhang et al.…”

Section: Discussionmentioning

confidence: 99%

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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review

Shervedani,

Tabibian,

Khotbesara

et al. 2023

Clinical Case Reports

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Key Clinical MessageWe presented a patient, diagnosed with lymphoma‐associated CLIPPERS, 11 years after lymphoma treatment. Therefore, CLIPPERS may be paraneoplastic neurological syndrome of lymphoma, which needs to be considered in the follow‐up of lymphoma cases.AbstractChronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system disorder with a recent increase in incidence. There are few reports of lymphoma‐associated CLIPPERS, although the relationship between these two diseases and the pathophysiology of CLIPPERS in general need further investigation. Here, we present a patient with a history of Hodgkin's lymphoma (HL) more than 10 years before the onset of CLIPPERS, in contrast to the majority of previously reported lymphoma‐associated cases, and discuss the possibility that CLIPPERS is the paraneoplastic neurological syndrome of HL. This highlights the need to consider CLIPPERS as a differential diagnosis during follow‐up of patients with a history of lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review

Shervedani,

Tabibian,

Khotbesara

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

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Brain biopsy in patients with CLIPPERS syndrome: why and when? A case report and literature review

Galazky

Büntjen

Voges

et al. 2022

Ther Adv Neurol Disord

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CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is an inflammatory disorder of the central nervous system (CNS), predominantly involving the brainstem with a characteristic magnetic resonance imaging (MRI) appearance and clinical and radiological responsiveness to glucocorticosteroids. Yet diagnostic biomarkers are missing and other immune-mediated, (para-) infectious and malignant causes mimic CLIPPERS-like MRI presentations. We report the case of a 51-year-old male patient with CLIPPERS who repeatedly responded well to high-dose corticosteroids. After 7 months, however, treatment failed, and he had a biopsy-confirmed diagnosis of a CNS B-cell lymphoma. Clinical and MRI signs of CLIPPERS include a wide spectrum of differential diagnoses which often arise only later during the course of disease. Similar to the case presented here, delayed diagnosis and specific therapy may contribute to an unfavorable outcome. Hence, we propose that in the absence of other diagnostic markers, brain biopsy should be performed as early as possible in CLIPPERS patients.

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CLIPPERS-Syndrom: Eine Erkrankung mit vielen Gesichtern – ein Fallbericht

Cited by 2 publications

References 15 publications

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review

Brain biopsy in patients with CLIPPERS syndrome: why and when? A case report and literature review

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