CLOCK/BMAL1 is Involved in Lipid Metabolism via Transactivation of the Peroxisome Proliferator-activated Receptor (PPAR) Response Element

Inoue, Ituro; Shinoda, Yasutoshi; Ikeda, Masaaki; Hayashi, Kenji; Kanazawa, Kenta; Nomura, Masahiko; Matsunaga, Toshiyuki; Xu, Hui; Kawai, Shinichiro; Awata, Takuya; Komoda, Tsugikazu; Katayama, Shigehiro

doi:10.5551/jat.12.169

Cited by 125 publications

(76 citation statements)

References 29 publications

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“…Our own and other laboratories have demonstrated that liver-type (L-FABP) and intestine-type (I-FABP) fatty acid-binding proteins, which are proteins mediating fatty acid absorption from lumen to enterocyte, are induced by dietary fat in adult rats (19,20,22,30). Additionally, previous studies have demonstrated that the gene expression of cellular retinol binding protein (CRBPII), which is a protein allowing absorption of retinol from lumen to enterocyte, is up-regulated by dietary fat (21,22,25,(31)(32)(33). Recent studies have shown that these genes, including L-FABP and CRBPII, possess a direct repeat with one space (DR-1) of AGGTCA-like motifs in their promoter regions (11, 34, …”

Section: Discussionmentioning

confidence: 99%

Possible Role of Fatty Acids in Milk as the Regulator of the Expression of Cytosolic Binding Proteins for Fatty Acids and Vitamin A through PPAR.ALPHA. in Developing Rats

Mochizuki

Kawai

et al. 2007

J Nutr Sci Vitaminol

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Summary Fatty acids in milk are thought to play an important role in intestinal maturation and gene expression in the postnatal small intestine. In this study, we determined the jejunal mRNA levels, in rats, of peroxisome proliferator-activated receptor ␣ (PPAR ␣ ) and PPAR ␦ which are nuclear receptors for fatty acids. We also measured expression of their target genes during the postnatal period, namely liver type fatty acid-binding protein (L-FABP) and cellular retinol-binding protein, type II (CRBPII). The mRNA levels of PPAR ␣ , L-FABP and CRBPII, but not PPAR ␦ , gradually increased during the suckling period and then sharply declined to a low level at the end of the weaning period. Rat pups at 17 d of age, weaned to a high-fat diet, showed significantly greater mRNA levels of PPAR ␣ , L-FABP and CRBPII than those weaned to a low-fat diet. Oral administration of PPAR ␣ ligand, WY14,643 during four consecutive days of the weanling period caused a parallel increase in the mRNA levels of PPAR ␣ , L-FABP and CRBPII genes. Furthermore, caprylic acid and oleic acid, which are major components of fatty acids in milk, induced jejunal PPAR ␣ , L-FABP and CRBPII gene expression. Our results suggest that fatty acids in milk may play a pivotal role in maintaining an enhanced level of expression of L-FABP and CRBPII genes in the small intestine, presumably by acting as inducers of PPAR ␣ gene expression.

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Section: Discussionmentioning

confidence: 99%

Possible Role of Fatty Acids in Milk as the Regulator of the Expression of Cytosolic Binding Proteins for Fatty Acids and Vitamin A through PPAR.ALPHA. in Developing Rats

Mochizuki

Kawai

et al. 2007

J Nutr Sci Vitaminol

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“…In skeletal muscle, RORα regulates lipid homeostasis via direct activation of carnitine palmitoyltransferase 1 (`mqN), involved in fatty acid oxidation, and caveolin-3 (Lau et al, 2004). Rhythmic transcriptional activation by CLOCK/BMAL1 is a key regulator of lipid metabolic enzymes such as acyl-CoA oxidase (^lu), 3-hydroxy-3-methylglutaryl coenzyme A (ejdJ`ç^) synthase (eãÖÅëN) and cellular retinol binding protein II (`o_m=ff) (Inoue= et alK, 2005).…”

Section: Circadian Control Of Metabolismmentioning

confidence: 99%

A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock

Kovac

Husse

Oster

2009

Molecules and Cells

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The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.

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“…Both the PPARα transcript and protein oscillate in mouse liver with a time of peak expression consistent with regulation by local circadian clocks (Lemberger et al 1996). Pparα transcription can be directly regulated by CLOCK and BMAL1 in vitro and in the liver and intestine in vivo (Inoue et al 2005;Oishi et al 2005;Canaple et al 2006). As discussed above, the endogenous PPARα ligand OEA is synthesized diurnally in the gut epithelium, probably in response to nutrient availability.…”

Section: Pparsmentioning

confidence: 99%

Nuclear Receptors, Metabolism, and the Circadian Clock

Yang¹,

Lamia²,

Evans³

2007

Cold Spring Harbor Symposia on Quantitative Biology

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As ligand-dependent transcription factors, the nuclear receptor superfamily governs a remarkable array of rhythmic physiologic processes such as metabolism and reproduction. To provide a "molecular blueprint" for nuclear receptor function in circadian biology, we established a diurnal expression profile of all mouse nuclear receptors in critical metabolic tissues. Our finding of broad expression and tissue-specific oscillation of nuclear receptors along with their key target genes suggests that diurnal nuclear receptor expression may contribute to established rhythms in metabolic physiology and that nuclear receptors may be involved in coupling peripheral circadian clocks to divergent metabolic outputs. Conversely, nuclear receptors may serve peripheral clock input pathways, integrating signals from the light-sensing central clock in the suprachiasmatic nucleus and other environmental cues, such as nutrients and xenobiotics. Interplay between the core circadian clock and nuclear receptors may define a large-scale signaling network that links biological timing to metabolic physiology.

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CLOCK/BMAL1 is Involved in Lipid Metabolism via Transactivation of the Peroxisome Proliferator-activated Receptor (PPAR) Response Element

Cited by 125 publications

References 29 publications

Possible Role of Fatty Acids in Milk as the Regulator of the Expression of Cytosolic Binding Proteins for Fatty Acids and Vitamin A through PPAR.ALPHA. in Developing Rats

Possible Role of Fatty Acids in Milk as the Regulator of the Expression of Cytosolic Binding Proteins for Fatty Acids and Vitamin A through PPAR.ALPHA. in Developing Rats

A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock

Nuclear Receptors, Metabolism, and the Circadian Clock

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