Clofibrate disposition in renal failure and acute and chronic liver disease

Gugler, R; Kürten, Julia; Jensen, Chris; Klehr, U.; Hartlapp, J. H.

doi:10.1007/bf00558438

Cited by 50 publications

(11 citation statements)

References 24 publications

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“…Conjugation with glucuronic acid (to form an ester glucuronide) is the major route of ketoprofen elimination-approximately 65% of an oral dose is recovered in urine as ketoprofen glucuronide (Verbeeck et al, 1983). Urinary excretion of unchanged drug accounts for only a very small fraction of the overall elimination (Upton et al, 1980 (Gugler et al, 1979;Verbeeck et al. 1983).…”

mentioning

confidence: 99%

Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.

Verbeeck¹,

Wallace²,

Loewen³

1984

Brit J Clinical Pharma

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confidence: 99%

Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.

Verbeeck¹,

Wallace²,

Loewen³

1984

Brit J Clinical Pharma

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“…Furthermore, plasma conjugates could not be detected in patients receiv ing repeated doses (100 mg/day) of fenofibrate during 2 weeks. Indeed, it was observed that the toxic effect, muscle aching with increase of CPK [II] induced by clofibrate in renal patients but not observed with fenofibrate in our study, was due to the considerable CPIB conjugate plasma levels [5,6].…”

Section: Discussionmentioning

confidence: 80%

Effect of Hemodialysis on Plasma Kinetics of Fenofibrate in Chronic Renal Failure

Desager

Costermans

Verberckmoes

et al. 1982

Nephron

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The influence of hemodialysis on plasma fenofibric acid kinetics has been investigated in patients with chronic renal failure given 300 mg of fenofibrate in a single oral dose. A very pronounced lengthening of the fenofibric acid plasma decay was observed in both hemodialyzed (n = 6) and nonhemodialyzed (n = 9) patients. Hemodialysis did not modify the plasma levels and the ultrafiltrates contained very small amounts of fenofibric acid. The repeated daily administration of 100 mg of fenofibrate during 2 weeks in 5 renal patients on regular hemodialysis resulted in increasing plasma levels and led to progressive cumulation of fenofibric acid. Plasma fenofibric acid conjugates could not be detected. No particular clinical side effects or increase of CPK, GOT, GPT were be observed.

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“…The principal pharmacokinetic parameters of (Gugler & Hartlapp, 1978;Gugler et al, 1979;Faed & McQueen, 1979). It is reported that about 5-20% of the dose administered is excreted in urine as the unchanged compound and the glucuronide accounts for 80-85% of the dose ingested (Houin, 1975;Gugler, 1978).…”

Section: Resultsmentioning

confidence: 99%

Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man.

Houin¹,

Shastri²,

Barré³

et al. 1984

Brit J Clinical Pharma

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1 A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p-chlorophenolic (PCP) ester of CPIB. 2 Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 + 4.6 mg 1-1 as against a value of 15.2 + 6.9 mg 1-' in the latter (P < 0.01). 3 The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. 4 It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.

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Clofibrate disposition in renal failure and acute and chronic liver disease

Cited by 50 publications

References 24 publications

Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.

Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.

Effect of Hemodialysis on Plasma Kinetics of Fenofibrate in Chronic Renal Failure

Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man.

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