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1 An oral dose of 75 mg/kg body weight was used to study the kinetics of sulphafurazole in wellnourished and undernourished adult subjects. 2 There were no differences in the half‐life, volume of distribution and total body clearance of the drug in the two groups of subjects. 3 The plasma protein binding of sulphafurazole was significantly reduced in the undernouished subjects. 4 It is concluded that alternations in the dosage schedule may not be necessary in the treatment of undernourished adults with sulphafurazole.

1 A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p-chlorophenolic (PCP) ester of CPIB. 2 Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 + 4.6 mg 1-1 as against a value of 15.2 + 6.9 mg 1-' in the latter (P < 0.01). 3 The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. 4 It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.