Clonal analysis of a B-cell lymphoma with recurrent spontaneous remissions and evolution into chronic lymphocytic leukaemia

Nagel, S; Borisch, Bettina; Rohr, A. von; Tobler, Andreas; Fey, Martin F.

doi:10.1093/oxfordjournals.annonc.a010799

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…Instability of minisatellites in tumors has not been extensively studied (Armour et al, 1989;Nagel et al, 1995;Nikiforov et al, 1998). In the most frequently aected locus described (D17S30) most of the observed changes are due to LOH (Phillips et al, 1993(Phillips et al, , 1996Shipman et al, 1996).…”

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confidence: 99%

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

et al. 2001

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Telomerase activation is crucial in human carcinogenesis. The limiting component of telomerase, the catalytic subunit (hTERT), is undetectable in normal somatic cells but present in most tumor cells, including the earliest stages of colon carcinoma. The mechanisms involved in the dierential expression in normal and tumor cells are not understood. In normal cells hTERT expression is shut down by a repressor, and upregulation could be a consequence of cis-acting changes in the hTERT gene, making it resistant to repression. We have identi®ed a polymorphic and a monomorphic minisatellite in the second intron of the hTERT gene, and polymorphic one in intron 6. The polymorphic minisatellite in intron 2 contains binding sites for c-Myc, which has been shown to upregulate hTERT transcription. Screening colon carcinoma DNAs for rearrangements of hTERT minisatellites we detected no changes in 33 samples from tumors, most of which express hTERT. This indicates that size rearrangements of the hTERT minisatellites are not required for telomerase expression in colon carcinomas. Minor changes and one LOH were seen in ®ve tumors. Oncogene (2001) 20, 2600 ± 2605.

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confidence: 99%

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

et al. 2001

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“…Repeated cycles of spontaneous remission and relapse were previously documented in some cases of SLL/CLL [18], T-cell-rich B cell lymphoma [19], follicular lymphoma [20], diffuse lymphocytic well-differentiated lymphoma [21]and nodular mixed lymphocytic histiocytic lymphoma [22]. However, the mechanisms controlling tumor progression in these cases remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Expression of Wild-Type p53 and Bcl-2 Family Genes Oscillates with Recurrent Remission and Relapse in an Unusual Case of Low-Grade Lymphoma

Aizman

Many²,

Peller³

et al. 2000

Acta Haematol

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Downregulation of apoptosis has been proposed as a mechanism of clonal expansion in low-grade B cell neoplasms. We have previously described an unusual case of CD5+ B cell lymphoma characterized by cycles of leukemic phase alternating with spontaneous remission. In the present study, we examined the involvement of apoptosis-related proteins in the progression of this cyclic lymphoma ex vivo. During the leukemic phases, the clonal cells were activated blasts expressing elevated levels of wild-type (wt) p53, Bcl-2, Bcl-x_L, and Bax, while Bak expression increased during the decline of lymphocytosis. Bax heterodimerized with Bcl-2 but not with Bcl-x_L. The anti-apoptotic Bcl-2/Bax heterodimers peaked during early leukemic phases and declined during regression. The elevation in Bcl-2, Bcl-x_L and Bax expression during early leukemic phases seems to result from cell activation since a similar increase was induced by activating the remission phase leukemic cells in culture. The data suggest that wt p53, Bcl-x_L, and Bcl-2/Bax heterodimers support the accumulation of activated leukemic cells during the leukemic phases, while Bax and Bak may be involved in their decline during regression.

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Spontanremissionen

Kappauf¹,

Gallmeier²

2006

Kompendium Internistische Onkologie

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Clonal analysis of a B-cell lymphoma with recurrent spontaneous remissions and evolution into chronic lymphocytic leukaemia

Cited by 8 publications

References 39 publications

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

Expression of Wild-Type p53 and Bcl-2 Family Genes Oscillates with Recurrent Remission and Relapse in an Unusual Case of Low-Grade Lymphoma

Spontanremissionen

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