Clonal Dissemination and mupA Gene Polymorphism of Mupirocin-Resistant Staphylococcus aureus Isolates from Long-Term-Care Facilities in South Korea

Prevalence of clinical meticillin-resistant Staphylococcus aureus (MRSA) with high-level mupirocin resistance in Shanghai and Wenzhou, China

“…These results indicated that clonal dissemination was likely to contribute most to the spread of MuH MRSA within most of the hospitals in this investigation. Similar findings were also reported by Petinaki et al [5], Gadepalli et al [21] and Yoo et al [25]. However, in one of the hospitals (Hospital I) from Shanghai region, the molecular diversity of the MuH strains showed that the prevalence of MuH was due mainly to plasmid transmission.…”

Antimicrobial resistance of Staphylococcus aureus isolated from skin infections and its implications in various clinical conditions in Korea

“…However, a recent multicenter study conducted in the USA showed a slightly higher rate of resistance (10.8%) . In South Korea, topical mupirocin has been available since 1994 . In the present study, 8.4% of S. aureus isolates were found to be resistant.…”

“…Resistance rates are lowest (0.3%) in the USA, where fusidic acid is unavailable in clinical practice . Since its introduction in 1980, fusidic acid has been a popular over‐the‐counter topical antimicrobial in South Korea. A study from 2006 reported a resistance rate to fusidic acid of 23.9% .…”

Restriction fragment length polymorphism (RFLP) patterns and sequence analysis of high-level mupirocin-resistant meticillin-resistant staphylococci

“…In a previous study, we first reported that high-and low-level mupirocin-resistant MRSA was spreading in South Korean long-term care facilities (LTCFs) [29]. In this study, we investigated the restriction fragment length polymorphism (RFLP) patterns of the mupA gene on the Mupr plasmid and analysed sequence variations between the trs gene complex, IS and the mupA gene to confirm the cause of RFLP pattern variation in high-level mupirocin-resistant (MuH) staphylococci isolated from South Korean hospitals.…”