Clonal Diversity of Methicillin-resistant Staphylococcus aureus in UKM Medical Centre: Characterisation by Multilocus Sequence Typing of Different SCCmec Type Representatives

Muttaqillah, Najihan Abdul Samat; Hussin, Supyan; Hui, Min; Noordin, Ainihayati; Chuan, Hun Ding; Wahab, Asrul Abdul; Rahman, Mostafizur

doi:10.17576/jsm-2015-4409-14

Cited by 5 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another paper that reported on MRSA isolates obtained in the Malaysian state of Perak in 2011 and 2012 also showed the predominance of SCC mec type III, but with the emergence of SCC mec type IV among 175 non-repetitive isolates [21]. Although the predominant clone in Malaysia appeared to be ST239 with SCC mec type III, Samat et al made an interesting discovery of the first ST239 containing an SCC mec type II [78]. The strain, which was isolated from a skin swab in an orthopedic clinic, was the first of its kind to be reported.…”

Section: Clonal Types and Characteristics Of Malaysian S Aureus Imentioning

confidence: 99%

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

et al. 2019

View full text Add to dashboard Cite

Staphylococcus aureus is an important nosocomial pathogen and its multidrug resistant strains, particularly methicillin-resistant S. aureus (MRSA), poses a serious threat to public health due to its limited therapeutic options. The increasing MRSA resistance towards vancomycin, which is the current drug of last resort, gives a great challenge to the treatment and management of MRSA infections. While vancomycin resistance among Malaysian MRSA isolates has yet to be documented, a case of vancomycin resistant S. aureus has been reported in our neighboring country, Indonesia. In this review, we present the antimicrobial resistance profiles of S. aureus clinical isolates in Malaysia with data obtained from the Malaysian National Surveillance on Antimicrobial Resistance (NSAR) reports as well as various peer-reviewed published records spanning a period of nearly three decades (1990–2017). We also review the clonal types and characteristics of Malaysian S. aureus isolates, where hospital-associated (HA) MRSA isolates tend to carry staphylococcal cassette chromosome mec (SCCmec) type III and were of sequence type (ST)239, whereas community-associated (CA) isolates are mostly SCCmec type IV/V and ST30. More comprehensive surveillance data that include molecular epidemiological data would enable further in-depth understanding of Malaysian S. aureus isolates.

show abstract

Section: Clonal Types and Characteristics Of Malaysian S Aureus Imentioning

confidence: 99%

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

et al. 2019

View full text Add to dashboard Cite

show abstract

“… MRSA = methicillin-resistant Staphylococcus aureus ; SCC mec = staphylococcal cassette chromosome mec ; MLST = multilocus sequence type; PVL = Panton-Valentine leucocidin; HA = hospital-acquired; CA = community-acquired; = not reported; nt = nontypable; − = negative; + = positive; * = multisensitive MRSA can be defined as MRSA isolate that is resistant to cefoxitin and sensitive to antibiotics other than beta-lactam antibiotics; ** = the SCC mec types were arranged based on the most to the lowest types reported except for the study by Muttaqillah et al ( 31 ) due to their types of sampling strategy; *** = no correlation between typing, MRSA acquisition and the presence of PVL gene; **** = PVL gene results were reported based on previous paper; ***** = infection type was reported instead of sample type …”

Section: Tablementioning

confidence: 99%

“… ** = the SCC mec types were arranged based on the most to the lowest types reported except for the study by Muttaqillah et al ( 31 ) due to their types of sampling strategy; …”

Section: Tablementioning

confidence: 99%

“…Later in 2008, Lim et al ( 22 ) discovered CA-MRSA SCC mec type V from isolates at the same hospital. Meanwhile, in the year 2009, type II was reported in Malaysia ( 31 ). The study reported that one of the type II isolates was associated with ST239.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from ST239, ST22-IV was also described among the isolates since 2003. Subsequently, detection of ST22 remained in low incidence except in two different studies in 2008 and 2010 ( 25 , 31 ) where no ST22-IV was isolated. ST22-IV, or epidemic MRSA-15 (EMRSA-15), is a dominant clone regularly found in the UK.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective

Junaidi¹,

Shakrin²,

Desa³

et al. 2023

MJMS

View full text Add to dashboard Cite

The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia.

show abstract

Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital

Farook,

Argimón,

Samat

et al. 2024

International Journal of Medical Microbiology

View full text Add to dashboard Cite

Clonal Diversity of Methicillin-resistant Staphylococcus aureus in UKM Medical Centre: Characterisation by Multilocus Sequence Typing of Different SCCmec Type Representatives

Abstract: Multilocus sequence typing (MLST) has been used to characterise methicillin-resistant

Cited by 5 publications

References 24 publications

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective

Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital

Contact Info

Product

Resources

About