Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China

Li, Xingping; Fang, Liang‐Xing; Song, Jiaqi; Xia, Jing; Huo, Wei; Fang, Jin-Tao; Liao, Xiao‐Ping; Liu, Yahong; Feng, Youjun; Sun, Jian

doi:10.1038/srep38511

Cited by 58 publications

(53 citation statements)

References 45 publications

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“…Compared to other bacterial species of Enterobacteriaceae , the prevalence rate of mcr-1 in Salmonella was found to be much lower in each of these surveys, regardless of the site of recovery 16 – 20 . The low prevalence of mcr-1 was also reported in a study from China, England and Wales 3 , 21 . However, another study in China reported the high prevalence of Salmonella from animals 9 .…”

Section: Discussionsupporting

confidence: 69%

Distinct mechanisms of acquisition of mcr-1 –bearing plasmid by Salmonella strains recovered from animals and food samples

Cui¹,

Zhang

et al. 2017

Sci Rep

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Since the report of its discovery in E. coli in late 2015, the plasmid-mediated colistin resistance gene, mcr-1, has been detected in various bacterial species in clinical setting and various environmental niches. However, the transmission mechanisms of this gene in Salmonella is less defined. In this study, we conducted a comprehensive study to characterize the genetic features of mcr-1-positive Salmonella strains isolated from animals and foods. Our data revealed that Salmonella recovered from animals and food specimens exhibited highly different PFGE patterns, and acquired mcr-1-encoding plasmids via different mechanism. Plasmids harboring mcr-1 in Salmonella food isolates were all conjugative and similar as plasmids reported in other species of Enterobacteriaceae, whereas mcr-1-bearing plasmids from animal Salmonella isolates were not conjugative, and belonged to the IncHI2 type. The lack of a region carrying the tra genes was found to account for the inability to undergo conjugation for various sizes of IncHI2 plasmids harbored by animal strains. These data suggest that transmission of mcr-1-positive Salmonella from animal to food might not be a common event and food isolates may have acquired mcr-1-bearing plasmids from other mcr-1-positive bacteria such as E. coli, which co-exist in food samples.

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Section: Discussionsupporting

confidence: 69%

Distinct mechanisms of acquisition of mcr-1 –bearing plasmid by Salmonella strains recovered from animals and food samples

Cui¹,

Zhang

et al. 2017

Sci Rep

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“…Compared with the extensive Plasmid-mediated colistin resistance in animals Plasmid-mediated colistin resistance in animals surveys focused on E. coli, to date, limited information is available for mcr-1-carrying Salmonella in China. The ST34 Salmonella isolate was reportedly involved in the spread of the mcr-1 in Salmonella enterica from food animals in China (Li et al, 2016b;Yi et al, 2017). In Japan, a high proportion of colistin-resistant (45%) pathogenic and mcr-1-positive (13%) E. coli were reported in swine production (Kusumoto et al, 2016).…”

Section: Livestockmentioning

confidence: 99%

Plasmid-mediated colistin resistance in animals: current status and future directions

Sun

Zeng

et al. 2017

Anim. Health. Res. Rev.

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Colistin, a peptide antibiotic belonging to the polymyxin family, is one of the last effective drugs for the treatment of multidrug resistant Gram-negative infections. Recent discovery of a novel mobile colistin resistance gene, mcr-1, from people and food animals has caused a significant public health concern and drawn worldwide attention. Extensive usage of colistin in food animals has been proposed as a major driving force for the emergence and transmission of mcr-1; thus, there is a worldwide trend to limit colistin usage in animal production. However, despite lack of colistin usage in food animals in the USA, mcr-1-positive Escherichia coli isolates were still isolated from swine. In this paper, we provided an overview of colistin usage and epidemiology of mcr-1 in food animals, and summarized the current status of mechanistic and evolutionary studies of the plasmid-mediated colistin resistance. Based on published information, we further discussed several non-colistin usage risk factors that may contribute to the persistence, transmission, and emergence of colistin resistance in an animal production system. Filling the knowledge gaps identified in this review is critical for risk assessment and risk management of colistin resistance, which will facilitate proactive and effective strategies to mitigate colistin resistance in future animal production systems.

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“…This indicated that the structure ISApl1-mcr-1-pap2-ISApl1 could be inserted into diverse positions of IncHI2 plasmids. Prior to the current study, IncHI2 plasmids bearing mcr-1 have been identified only in strains of E. coli and Salmonella [4,5]. The current study provides insight into the widespread of mcr-1-bearing IncHI2 plasmids in Enterobacteriaceae, which play a remarkable role in the transmission of mcr-1.…”

Section: Emergence Of the Colistin Resistance Gene Mcr-1 In Citrobactmentioning

confidence: 86%

Emergence of the colistin resistance gene mcr-1 in Citrobacter freundii

Fang

Jiang

et al. 2017

International Journal of Antimicrobial Agents

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Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China

Cited by 58 publications

References 45 publications

Distinct mechanisms of acquisition of mcr-1 –bearing plasmid by Salmonella strains recovered from animals and food samples

Distinct mechanisms of acquisition of mcr-1 –bearing plasmid by Salmonella strains recovered from animals and food samples

Plasmid-mediated colistin resistance in animals: current status and future directions

Emergence of the colistin resistance gene mcr-1 in Citrobacter freundii

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