Cloning and characterization of a lung-specific cDNA corresponding to the γ chain of hepatic fibrinogen

Simpson-Haidaris, Patricia J.; Wright, Terry W.; Earnest, Barbara J.; Zhang, Hui; Neroni, Laurie A.; Courtney, Mary-Anne

doi:10.1016/0378-1119(95)00679-6

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…The pattern of expression of the serine proteinase inhibitor genes is profoundly modified during an inflammatory response, with transcription of the SPI-3 gene being greatly stimulated, whereas the transcription of the SPI-1 and SPI-2 genes being suppressed (29). Hence a further indication of proinflammatory response in rats fed diets deficient in Se plus VE is that they exhibited higher expression of the fibrinogen gamma chain, which has been shown to be significantly upregulated in the rat liver during inflammation (30). The induction of proinflammatory genes was accompanied by a concerted depression of the antiinflammatory enzyme 11-beta-hydroxysteroid dehydrogenase 2, which converts the glucocorticoid corticosterone to its inactive 11-dehydro form in the rat, thereby controlling glucocorticoid access to receptors (31).…”

Section: Antioxidant Defense Stress Response and Inflammationmentioning

confidence: 93%

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Fischer

Pallauf

Gohil

et al. 2001

Biochemical and Biophysical Research Communications

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Section: Antioxidant Defense Stress Response and Inflammationmentioning

confidence: 93%

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Fischer

Pallauf

Gohil

et al. 2001

Biochemical and Biophysical Research Communications

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“…31,32 Extrahepatic expression of fibrinogen occurs in vivo, as demonstrated in animal models of Pneumocystis carinii pneumonia, and by gene expression profiling of biopsy samples from patients with lung or breast cancer. [33][34][35][36][37][38][39] The functional significance of fibrinogen expression by extrahepatic epithelium is likely influenced more by the cellular context in which the fibrinogen is found rather than by its overall plasma concentration.…”

Section: Letters To the Editormentioning

confidence: 99%

Author's reply to Weijers et al. “Fibrin β^15–42 domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.”

Simpson-Haidaris

Sahni

2010

Intl Journal of Cancer

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“…6 Although the primary site for Fg synthesis is shown to be liver, extrahepatic synthesis of Fg by epithelial cells of intestine, 7 cervix, 8 and lung 9,10 has been reported, suggesting that it may function in other structural and functional capacities. Furthermore, endogenous expression of Fg␣ and Fg␤ chain mRNA has been shown in the normal rat kidneys, levels of which significantly increase at 2 hours after the onset of brain death injury, 11,12 potentially restoring hemostasis by supporting extracellular matrix and wound repair processes after injury.…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen β–derived Bβ15-42 peptide protects against kidney ischemia/ reperfusion injury

Krishnamoorthy

Ajay

Hoffmann

et al. 2011

Blood

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Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels of fibrinogen (Fg)␣, Fg␤, and Fg␥ chains significantly increase in the kidney and remain elevated throughout the regeneration process. Cellular characterization of Fg␣ and Fg␥ chain immunoreactive proteins shows a predominant expression in renal tubular cells and the localization of immunoreactive Fg␤ chain protein is primarily in the renal interstitium in healthy and regenerating kidney. We also show that urinary excretion of Fg is massively increased after kidney damage and is capable of distinguishing human patients with acute or chronic kidney injury (n ‫؍‬ 25) from healthy volunteers (n ‫؍‬ 25) with high sensitivity and specificity (area under the receiver operating characteristic of 0.98). Furthermore, we demonstrate IntroductionKidney disease is a major public health concern receiving increased global attention owing to the significantly increased prevalence and high mortality rates. 1,2 Renal ischemia/reperfusion (I/R) accounts for a significant number of acute kidney injury (AKI) cases in humans. Studies suggest that damage to the renal microvascular architecture and deterioration of the angiogenic response constitutes the early steps in the complex multiple pathways involved in both early and chronic ischemic renal injury. 3 Restoration of blood flow to the site of injured tissue is crucial for developing a successful repair response that involves the surviving dedifferentiated cells spreading over the denuded basement membrane, undergoing mitogenesis and ultimately redifferentiating to re-establish and restore functional integrity of the nephron. 4,5 Although these processes are well described at the pathologic level, very little is known about the cellular and molecular mechanisms of action of blood proteins within the kidney and their contribution to pathogenesis of renal disease.Fibrinogen (Fg), a 340-kDa dimeric blood protein, is made up of 2 sets of 3 different polypeptide chains, Fg␣, Fg␤, and Fg␥, that span a length of 50 kb on chromosome 4 in region q28. 6 Although the primary site for Fg synthesis is shown to be liver, extrahepatic synthesis of Fg by epithelial cells of intestine, 7 cervix, 8 and lung 9,10 has been reported, suggesting that it may function in other structural and functional capacities. Furthermore, endogenous expression of Fg␣ and Fg␤ chain mRNA has been shown in the normal rat kidneys, levels of which significantly increase at 2 hours after the onset of brain death injury, 11,12 potentially restoring hemostasis by supporting extracellular matrix and wound repair processes after injury. 12 In addition to its major role in blood clotting and circulation via interaction with platelets, 13 Fg has been recognized as an important regulator of inflammation, 14 wound ...

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Cloning and characterization of a lung-specific cDNA corresponding to the γ chain of hepatic fibrinogen

Cited by 13 publications

References 24 publications

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Author's reply to Weijers et al. “Fibrin β^15–42 domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.”

Fibrinogen β–derived Bβ15-42 peptide protects against kidney ischemia/ reperfusion injury

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Cloning and characterization of a lung-specific cDNA corresponding to the γ chain of hepatic fibrinogen

Cited by 13 publications

References 24 publications

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

Author's reply to Weijers et al. “Fibrin β15–42 domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.”

Fibrinogen β–derived Bβ15-42 peptide protects against kidney ischemia/ reperfusion injury

Contact Info

Product

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Author's reply to Weijers et al. “Fibrin β^15–42 domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.”