Cloning and expression of a cDNA for the human prostanoid FP receptor.

Abramovitz, Mark; Boie, Yves; Nguyen, Tuan; Rushmore, Thomas H.; Bayne, M A; Metters, Kathleen M.; Slipetz, Deborah; Grygorczyk, Ryszard

doi:10.1016/s0021-9258(17)41991-0

Cited by 255 publications

(25 citation statements)

References 33 publications

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“…The prostanoid receptors belong to the class A, rhodopsin-like GPCRs. Figure shows an alignment of the primary amino acid sequences of the eight human prostanoid receptors, DP1, EP1, EP2, EP3, EP4, FP, IP, and TP, and the leukocyte chemoattractant receptor family member DP2. ,,− The overall homology among the eight prostanoid receptors is not very high, ranging from ∼20% to 30% amino acid identity. That between the DP2 receptor and other prostanoid receptors is <20%.…”

Section: General Features Of Prostanoid Receptorsmentioning

confidence: 99%

Prostanoid Receptors

2011

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Section: General Features Of Prostanoid Receptorsmentioning

confidence: 99%

Prostanoid Receptors

2011

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“…We have attempted to understand the differences in the binding affinity of analogues based on a hFP receptor homology model constructed from the known human FP receptor amino acid sequencing data and site-directed mutagenesis studies . The computer model was created by mapping the transmembrane sections of the human FP receptor from the primary amino acid sequence onto the rhodopsin template of the seven-transmembrane domain receptors available from the Swiss Institute .…”

Section: Biological Results and Discussionmentioning

confidence: 99%

Design and Synthesis of 13,14-Dihydro Prostaglandin F_1α Analogues as Potent and Selective Ligands for the Human FP Receptor

et al. 2000

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The in vitro evaluation of a new class of potential bone anabolic agents for the treatment of osteoporosis is described. These compounds are potent and selective ligands for the human prostaglandin F receptor (hFP receptor). The compounds lack the olefin unsaturation required for potency in the natural ligand PGF(2)(alpha) yet retain binding affinity for the hFP receptor in the nanomolar to micromolar range. Removal of the alkenes also results in a better selectivity ratio for the hFP receptor over the other prostaglandin receptors tested. A rationale for the selectivity differences of various analogues, based on ligand docking experiments to a putative hFP receptor model, is also described.

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“…PGF2 α , an inflammatory mediator, plays a role through the FP receptor (one of the G protein-coupled receptors). FP receptor is expressed in vascular endothelial cells and vascular smooth muscle cells [ 12 ]. Activation of FP receptor triggers signal transduction by increasing intracellular calcium and inositol phosphate accumulation [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway

Sai

Jun

et al. 2022

Oxidative Medicine and Cellular Longevity

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Senescence in vascular smooth muscle cells (VSMCs) is involved in vascular remodeling of aged mice. ProstaglandinF2α- (PGF2α-) FP receptor plays a critical role in cardiovascular diseases (CVDs), hypertension, and cardiac fibrosis. However, its role in senescence-induced arteriosclerosis is yet to be fully elucidated. In this study, we found that FP receptor expression increased in aged mouse aortas and senescence VSMCs. FP receptor gene silencing can ameliorate vascular aging and inhibit oxidative stress, thereby reducing the expression of PAI-1, inhibiting the activation of MMPs, and ultimately improving the excessive deposition of ECM and delaying the process of vascular fibrosis. FP receptor could promote VSMC senescence by upregulated Src/PAI-1 signal pathway, and inhibited FP receptor/Src/PAI-1 pathway could ameliorate VSMCs aging in vitro, evidenced by the decrease of senescence-related proteins P16, P21, P53, and GLB1 expressions. These results suggested that FP receptor is a promoter of vascular aging, by inducing cellular aging, oxidative stress, and vascular remodeling via Src and PAI-1 upregulation.

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Cloning and expression of a cDNA for the human prostanoid FP receptor.

Cited by 255 publications

References 33 publications

Prostanoid Receptors

Prostanoid Receptors

Design and Synthesis of 13,14-Dihydro Prostaglandin F_1α Analogues as Potent and Selective Ligands for the Human FP Receptor

PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway

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Cloning and expression of a cDNA for the human prostanoid FP receptor.

Cited by 255 publications

References 33 publications

Prostanoid Receptors

Prostanoid Receptors

Design and Synthesis of 13,14-Dihydro Prostaglandin F1α Analogues as Potent and Selective Ligands for the Human FP Receptor

PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway

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Design and Synthesis of 13,14-Dihydro Prostaglandin F_1α Analogues as Potent and Selective Ligands for the Human FP Receptor