Cloning, Expression, and Chromosomal Location of SHH and IHH: Two Human Homologues of the Drosophila Segment Polarity Gene Hedgehog

Marigo, Valeria; Roberts, Drucilla J.; Lee, Scott M. K.; Tsukurov, Olga; Levi, Tatjana; Gastier, Julie M.; Epstein, Douglas J.; Gilbert, Debra J.; Copeland, Neal G.; Seidman, Christine E.; Jenkins, Nancy A.; Seidman, Jonathan G.; McMahon, Andrew P.; Tabin, Cliff

doi:10.1006/geno.1995.1104

Cited by 180 publications

(111 citation statements)

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“…There are three members in human Hh family i.e. Sonic HH (SHH), Indian HH (IHH), and Desert HH (DHH) (Echelard et al, 1993;Marigo et al, 1995). All these ligands bind to a 12-transmembrane receptor called Patched (PTCH) that restricts Hh signaling by inhibiting a 7-transmembrane receptor called smoothened (SMO) (Bijlsma et al, 2006).…”

Section: Expression and Clinical Significance Of Hedgehog Signaling Pmentioning

confidence: 99%

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Wang

Li²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: To investigate the expression of three components of the Hedgehog (Hh) signaling pathway (SHH, SMO and GLI1) in human colorectal cancer (CRC) tissues and evaluate their association with clinicopathologic characteristics of the patients. Methods: Fresh tumor tissues and matched tissues adjacent to the tumor were collected from 43 CRC patients undergoing surgery. Normal colorectal tissues from 20 non-CRC cases were also sampled as normal controls. The expression of SHH, SMO, GLI1 mRNAs was assessed by RT-PCR and proteins were detected by immunohistochemical staining. Associations with clinicopathological characteristics of patients were analyzed. Results: SHH mRNA was expressed more frequently in tumor tissues than in normal tissues, but the difference did not reach significance in comparison to that in the adjacent tissues. SMO and GLI1 mRNAs were expressed more frequently in tumor tissues than in both adjacent andnormal tissues. The expression intensities of SHH, SMO, GLI1 mRNA in tumor tissues were significantly higher than those in adjacent tissues and normal tissues. Proteins were also detected more frequently in tumors than other tissues. No significant links were apparent with gender, age, location, degree of infiltration or Dukes stage. Conclusion: Positive rates and intensities of mRNA and protein expression of Hh signaling pathway related genes SHH, SMO, GLI1 were found to be significantly increased in CRC tissues. However, over-expression did not appear to be associated with particular clinicopathological characteristics.

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Section: Expression and Clinical Significance Of Hedgehog Signaling Pmentioning

confidence: 99%

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Wang

Li²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…With this exception, DNA sequencing of the entire Shh 5' untranslated region and coding sequence confirmed the reported human Shh sequence. 27 …”

Section: Cloning Of Human Shh Cdnamentioning

confidence: 99%

Sonic hedgehog gene-enhanced tissue engineering for bone regeneration

et al. 2004

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“…Hedgehog family ligands, Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH), undergo autoprocessing and lipid modification to generate mature peptides (7)(8)(9). Hedgehog acyltransferase (HHAT) is one of Hedgehog modifiers (10).…”

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confidence: 99%

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

Katoh¹,

Katoh²

2006

Int J Mol Med

125

164

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Cloning, Expression, and Chromosomal Location of SHH and IHH: Two Human Homologues of the Drosophila Segment Polarity Gene Hedgehog

Cited by 180 publications

References 0 publications

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Sonic hedgehog gene-enhanced tissue engineering for bone regeneration

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

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