2001
DOI: 10.1006/geno.2001.6541
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Cloning, Mapping, and Characterization of the Human Sorbin and SH3 Domain Containing 1 (SORBS1) Gene: A Protein Associated with c-Abl during Insulin Signaling in the Hepatoma Cell Line Hep3B

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Cited by 57 publications
(51 citation statements)
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“…These observations thus suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men. Sorbin and SH3 domain-containing 1 (SORBS1) is a human homolog of c-Cbl-associated protein (CAP), 24 which is an important signaling molecule in insulin stimulation of glucose uptake in mouse adipocytes. [24][25][26][27] Phosphorylation of c-Cbl results in the dissociation of the c-Cbl-CAP complex from the insulin receptor and its translocation to a lipid raft domain of the plasma membrane.…”
Section: Discussionmentioning
confidence: 99%
“…These observations thus suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men. Sorbin and SH3 domain-containing 1 (SORBS1) is a human homolog of c-Cbl-associated protein (CAP), 24 which is an important signaling molecule in insulin stimulation of glucose uptake in mouse adipocytes. [24][25][26][27] Phosphorylation of c-Cbl results in the dissociation of the c-Cbl-CAP complex from the insulin receptor and its translocation to a lipid raft domain of the plasma membrane.…”
Section: Discussionmentioning
confidence: 99%
“…AF078666). A search of the GenBank database uncovered a 168-bp insert in A13 representing an alternative splice variant of CAP [12,17]. This 56-amino-acid insert is located immediately after amino acid 483 of mouse CAP and, based on the human genomic DNA sequence (GenBank acc.…”
Section: Identification Of Cap As a Mouse Insm1 Interacting Protein Bmentioning
confidence: 99%
“…Although lots of SH3 domain structures are available, it is still very hard to predict the interaction partners of a SH3 domain, largely because of the high versatility of SH3 domains. Previous studies showed that the SH3C domain of R85FL can interact with c-Cbl [22], 1-Afadin [23] and c-Abl [24]. The SH3C domain interacts with the PRR-containing partners with a novel consensus motif of PxPPxRxSSL pattern at their binding sites [25].…”
Section: Discussionmentioning
confidence: 98%