Cloning of a C-terminally truncated NK-1 receptor from guinea-pig nervous system

Baker, Sarah J.; Morris, J.L.; Gibbins, Ian L.

doi:10.1016/s0169-328x(03)00002-0

Cited by 43 publications

(30 citation statements)

References 43 publications

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“…For example, two K ϩ channels were observed in THP-1 cells only after differentiation into macrophages (51). Truncated NK-1R has been observed (14,30,32,52); however, its regulation in human immune cells has not previously been investigated. Our observed selective effect of PMA on the full-length NK-1R demonstrates a role for NK-1R in macrophage differentiation, yet the mechanism is unknown.…”

Section: Discussionmentioning

confidence: 99%

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

Lai

Kilpatrick

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

102

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Section: Discussionmentioning

confidence: 99%

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

Lai

Kilpatrick

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

102

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“…NK-1R is a G-protein coupled receptor and has the highest affinity for substance P over other tachykinin receptors and is found as two isoforms; a full-length form (407 amino acids) and a truncated form (311 amino acids; Fong et al, 1992; Baker et al, 2003). The truncated form of NK-1R binds substance P with 10-fold lower affinity than the long form (Douglas and Leeman, 2011).…”

Section: Localization Of Substance P and Nk-1r Within The Cnsmentioning

confidence: 99%

The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders

Johnson

Young

Marriott

2017

Front. Cell. Neurosci.

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The inflammatory responses of resident central nervous system (CNS) cells are now known to play a critical role in the initiation and progression of an array of infectious and sterile neuroinflammatory disorders such as meningitis, encephalitis, Parkinson’s disease, Alzheimer’s disease and multiple sclerosis (MS). Regulating glial inflammatory responses in a timely manner is therefore critical in preserving normal CNS functions. The neuropeptide substance P is produced at high levels within the CNS and its selective receptor, the neurokinin 1 receptor (NK-1R), is abundantly expressed by neurons and is present on glial cell types including microglia and astrocytes. In addition to its functions as a neurotransmitter in the perception of pain and its essential role in gut motility, this tachykinin is widely recognized to exacerbate inflammation at peripheral sites including the skin, gastrointestinal tract and the lungs. Recently, a number of studies have identified a role for substance P and NK-1R interactions in neuroinflammation and described the ability of this neuropeptide to alter the immune functions of activated microglia and astrocytes. In this review article, we describe the expression of substance P and its receptor by resident CNS cells, and we discuss the ability of this neuropeptide to exacerbate the inflammatory responses of glia and immune cells that are recruited to the brain during neurodegenerative diseases. In addition, we discuss the available data indicating that the NK-1R-mediated augmentation of such responses appears to be detrimental during microbial infection and some sterile neurodegenerative disorders, and propose the repurposed use of NK-1R antagonists, of a type that are currently approved as anti-emetic and anti-anxiolytic agents, as an adjunct therapy to ameliorate the inflammatory CNS damage in these conditions.

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“…Several studies have indicated the existence of isoforms of the tachykinin NK 1 receptor, differing in the length of the C-terminal tail (Fong et al, 1992;Baker et al, 2003). The role of the short isoform and whether it is biologically active remains controversial.…”

Section: Existence Of Additional Tachykinin Receptorsmentioning

confidence: 99%

Tachykinins and tachykinin receptors: a growing family

et al. 2004

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Cloning of a C-terminally truncated NK-1 receptor from guinea-pig nervous system

Cited by 43 publications

References 43 publications

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders

Tachykinins and tachykinin receptors: a growing family

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