Clorazepate Dipotassium: A New Benzodiazepine Antianxiety Agent

Case report: A Delirious Abstinence Syndrome associated with Clorazepate (TranxilenR)

“…Clorazepate was clinically introduced in 1972 and is being used in several countries (Charalampous et al 1973, Holmberg and Livstedt 1972, Robin et al 1974, Percy 1975. In as much as the development of dependency and delirium symptoms has been reported previously in connection with benzodiazepines (Barten 1965, Peters, Boeters 1970, Hanna 1972, Misra 1975 it is not surprising to find that clorazepate also causes these symptoms.…”

Clinical and biochemical comparison of clorazepate and diazepam

“…Clorazepate (clorazepate dipotassium; Tranxene (R)) is a new benzodiazepine drug with many of the pharmacological properties of diazepam (Holmberg and Livstedt, 1972;Charalampous et al, 1973). A controlled trial (Cooper et al, 1973) has shown it to be therapeutically effective in anxiety reactions and to produce fewer sideeffects than diazepam.…”

THE INFLUENCE OF URINE pH ON THE RENAL EXCRETION OF ICI 66082 IN MAN

“…In this context it would have been useful to follow the plasma levels for a longer period of time. In one of the two previously reported clorazepate overdoses, diarrhoea and vomiting following the ingestion of 187.5 mg (Charalampous et al, 1973) and in the other, transient mild confusion followed the ingestion of 750 mg (Dereux, 1970 (4-(2-hydroxy-3-isopropylaminopropoxy) phenylacetamide) has recently been shown to be an effective ,B-adrenoceptor blocking drug in man (Graham, Littlejohns, Prichard, Scales & Southorn, 1973) and some understanding of its pharmacokinetics is necessary prior to its more widespread use. An important parameter to be established at an early stage of such investigations is whether the renal excretion of the drug is altered by changes in urine pH, since this could lead to variable pharmacokinetics between subjects.…”