Closed-loop transcranial ultrasound stimulation with a fuzzy controller for modulation of motor response and neural activity of mice

Yuan, Yi; Ai, Long; Wu, Yongkang; Li, Xiaoli

doi:10.1088/1741-2552/ac7893

Cited by 7 publications

(5 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Yu et al (2021) showed that ultrasound can elicit direct responses in the rodent brain, independent of hearing. In our last research, we performed closed-loop ultrasound stimulation experiments, and found that the amplitude changes and dynamic responses on the electromyogram and LFP in normal mice were substantially similar to those in deaf mice, demonstrating that ultrasound induces motor responses and neural responses by stimulating brain tissue rather than indirect auditory effects ( Yuan et al, 2022 ). Therefore, we speculate that the changes in theta and gamma rhythms induced by ultrasound under peak and trough stimulation are not the results of auditory effects.…”

Section: Discussionmentioning

confidence: 99%

Phase-locked closed-loop ultrasound stimulation modulates theta and gamma rhythms in the mouse hippocampus

et al. 2022

Self Cite

View full text Add to dashboard Cite

Previous studies have demonstrated that open-loop transcranial ultrasound stimulation (TUS) can modulate theta and gamma rhythms of the local field potentials (LFPs) in the mouse hippocampus; however, the manner in which closed-loop TUS with different pressures based on phase-locking of theta rhythms modulates theta and gamma rhythm remains unclear. In this study, we established a closed-loop TUS system, which can perform closed-loop TUS by predicting the peaks and troughs of the theta rhythm. Comparison of the power, sample entropy and complexity, and phase-amplitude coupling (PAC) between the theta and gamma rhythms under peak and trough stimulation of the theta rhythm revealed the following: (1) the variation in the absolute power of the gamma rhythm and the relative power of the theta rhythm under TUS at 0.6–0.8 MPa differ between peak and trough stimulation; (2) the relationship of the sample entropy of the theta and gamma rhythms with ultrasound pressure depends on peak and trough stimulation; and (3) peak and trough stimulation affect the PAC strength between the theta and gamma rhythm as a function of ultrasound pressure. These results demonstrate that the modulation of the theta and gamma rhythms by ultrasound pressure depends on peak and trough stimulation of the theta rhythm in the mouse hippocampus.

show abstract

Section: Discussionmentioning

confidence: 99%

Phase-locked closed-loop ultrasound stimulation modulates theta and gamma rhythms in the mouse hippocampus

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our previous study [51], different types of controllers were used to automatically adjust the ultrasound intensities of distinct ultrasound stimulations based on the feedback of real-time parameters (the mean absolute value of the EMG and peak value of the LFP). We demonstrated that a closed-loop TUS with a fuzzy controller can achieve tracking control of the motor response and neural activity of mice.…”

Section: Discussionmentioning

confidence: 99%

Modulation effect of mouse hippocampal neural oscillations by closed-loop transcranial ultrasound stimulation

Dong¹,

Yan²,

Xie³

et al. 2022

J. Neural Eng.

Self Cite

View full text Add to dashboard Cite

Objective. Closed-loop transcranial ultrasound stimulation (TUS) can be applied at a specific time according to the state of neural activity to achieve timely and precise neuromodulation and improve the modulation effect. In a previous study, we found that closed-loop TUS at the peaks and troughs of the theta rhythm in the mouse hippocampus was able to increase the absolute power and decrease the relative power of the theta rhythm of local field potentials independent of the peaks and troughs of the stimulus. However, it remained unclear whether the modulation effect of this closed-loop TUS-induced mouse hippocampal neural oscillation depended on the peaks and troughs of the theta rhythm. Approach. In this study, we used ultrasound with different stimulation modes and durations to stimulate the peaks (peak stimulation) and troughs (trough stimulation) of the hippocampal theta rhythm. The local field potentials in the area of ultrasound stimulation were recorded and the amplitudes and power spectra of the theta rhythm before and after ultrasound stimulation were analyzed. Main results. The results showed that (1) the relative change in amplitude of theta rhythm decreases as the number of stimulation trials under peak stimulation increases; (2) the relative change in the absolute power of the theta rhythm decreases as the number of stimulation trials under peak stimulation increases; (3) the relative change in amplitude of the theta rhythm increases nonlinearly with the stimulation duration under peak stimulation, and; (4) the relative change in absolute power exhibits a nonlinear increase with stimulation duration under peak stimulation. Significance. These results suggest that the modulation effect of closed-loop TUS on theta rhythm is dependent on the stimulation mode and duration under peak stimulation. TUS has the potential to precisely modulate theta rhythm-related neural activity.

show abstract

“…Thus, a closed-loop brain neuromodulation system combining existing physical neuromodulation technologies, such as optogenetics, deep brain stimulation [ 176 ], transcranial electrical stimulation [ 177 ], and transcranial magnetic stimulation has been developed [ 178 ]. There have also been recent reports on closed-loop ultrasound neuromodulation systems, owing to the advantages of closed-loop brain stimulation [ 179 – 181 ] (Fig. 6 ).…”

Section: Ultrasound Bci-preliminary Studies Based On Eegmentioning

confidence: 99%

“…Based on the CLTUS system, Yuan et al. [ 181 ] added a fuzzy algorithm to the control program to achieve timely and accurate control of the limb movement and nervous system of mice. The target of the ultrasound stimulation in this study was the motor cortex.…”

Section: Ultrasound Bci-preliminary Studies Based On Eegmentioning

confidence: 99%

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

et al. 2023

View full text Add to dashboard Cite

A noninvasive brain–computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science research. Current implanted brain–computer interfaces are cranial and invasive, which considerably limits their applications. The development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain–computer interfaces. Here, we review the theory and development of the ultrasound brain functional imaging and its applications. Furthermore, we introduce latest advancements in ultrasound brain modulation and its applications in rodents, primates, and human; its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also presented. Finally, high-frequency acoustic noninvasive brain–computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

show abstract

Closed-loop transcranial ultrasound stimulation with a fuzzy controller for modulation of motor response and neural activity of mice

Cited by 7 publications

References 61 publications

Phase-locked closed-loop ultrasound stimulation modulates theta and gamma rhythms in the mouse hippocampus

Phase-locked closed-loop ultrasound stimulation modulates theta and gamma rhythms in the mouse hippocampus

Modulation effect of mouse hippocampal neural oscillations by closed-loop transcranial ultrasound stimulation

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

Contact Info

Product

Resources

About