In this paper we are interested in finding and evaluating cardinal characteristics of the continuum that appear in large-scale topology, usually as the smallest weights of coarse structures that belong to certain classes (indiscrete, inseparable, large) of finitary or locally finite coarse structures on ω. Besides well-known cardinals b, d, c we shall encounter two new cardinals ∆ and Σ, defined as the smallest weight of a finitary coarse structure on ω which contains no discrete subspaces and no asymptotically separated sets, respectively. We prove that max{b, s, cov(N )} ≤ ∆ ≤ Σ ≤ non(M), but we do not know if the cardinals ∆, Σ, non(M) can be distinguished in suitable models of ZFC.