Closing in on DEHP‐free red blood cell concentrate containers

Almizraq, Ruqayyah J.; Acker, Jason P.

doi:10.1111/trf.14622

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Likely, differences in production processes will lead to different storage lesion results. In addition to the potential of alternative AS compositions [4, 10, 30–32], changes in processing may be another key factor to counteract disadvantageous RBC quality effects of DEHP removal [13]. As a future aspect, the individual contribution of different production parameters should be further explored.…”

Section: Discussionmentioning

confidence: 99%

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Non‐phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags

et al. 2020

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Background and objectives Commercial blood bags are predominantly made of polyvinyl chloride (PVC) plasticized with di(2‐ethylhexyl) phthalate (DEHP). DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality. Di(2‐ethylhexyl) terephthalate (DEHT) is one suggested substitute. The aim of this study was to compare PVC‐DEHT to PVC‐DEHP blood bags using additive solutions saline–adenine–glucose–mannitol (SAGM) and phosphate–adenine–glucose–guanosine–saline–mannitol (PAGGSM), to determine whether DEHT can maintain acceptable component quality. Materials and methods RBC concentrates (N = 64), platelet concentrates (N = 16) and fresh frozen plasma (N = 32) were produced from whole blood collected into either DEHT or DEHP plasticized systems. Using a pool‐and‐split study design, pairs of identical RBC content were created within each plasticizer arm and assigned either SAGM or PAGGSM. Storage effects were assessed weekly for 49 days (RBC), 7 days (platelets) and before/after freezing (plasma). Results Though haemolysis was slightly higher in DEHT, all study arms remained below half of the European limit 0·8%. K+ was lower in DEHT than in DEHP independent of additive solution. The metabolic parameters were not influenced by choice of plasticizer. Platelet activation/metabolism and plasma content were similarly preserved. Conclusion Our study demonstrates that the plasticizer DEHT provides adequate blood component quality. We propose DEHT as a strong future candidate for replacement of DEHP in blood bags.

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Section: Discussionmentioning

confidence: 99%

“…Several plasticizers have been suggested as substitutes to DEHP in blood bags. Di(2‐ethylhexyl) terephthalate (DEHT) and di‐isononyl cyclohexane‐1,2‐dicarboxylic acid (DINCH) have shown the greatest potential so far, despite providing inferior RBC quality in previous studies [9–13].…”

Section: Introductionmentioning

confidence: 99%

Non‐phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags

et al. 2020

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“…Dazu gehören BTHC (Butyryl-n-trihexylcitrat), DINCH (Cyclohexan-1,2-dicarboxylat), DEHT (Bis(2-ethylhexyl)terephthalat) und TOTM / TEHTM (Tris(2-ethylhexyl)trimellitat). Für diese Alternativen liegen erste Studien vor, die sie mit DEHP vergleichen und auf ihre Eignung prüfen 37 36 37 40 .…”

Section: Sonstige Herstellungsverfahrenunclassified

Moderne Methoden der Blutaufbereitung

Boecker,

Giss,

Johnsen

2024

Transfusionsmedizin

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ZusammenfassungVollblutspenden werden nach der Entnahme in Blutspendediensten zu den Blutkomponenten Erythrozytenkonzentrat, Therapeutisches Plasma und Thrombozytenkonzentrat weiterverarbeitet. Die Verarbeitung kann auf verschiedene Weise erfolgen. In diesem Übersichtsartikel erläutern wir die Unterschiede zwischen den beiden weltweit gebräuchlichsten Verfahren, dem Buffy-Coat-Verfahren und dem Plättchen-Reiches-Plasma-Verfahren, und beschreiben das in Deutschland standardgemäß eingesetzte semi-automatisierte Buffy-Coat Verfahren detaillierter. Darüber hinaus werden die verschiedenen Automatisierungsgrade in der Vollblutverarbeitung und die verschiedenen Ansätze zur weiteren Automatisierung beleuchtet. Im Rahmen dessen zeigen wir auf, welche Automatisierungsmaßnahmen in einigen Einrichtungen bereits umgesetzt werden konnten und welche neuen Techniken die weitere Automatisierung in Zukunft entscheidend prägen könnten.

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“…PVC material contains a high share of plasticizers, which are not chemical bound to the PVC itself and can thus easily migrate into contact liquids [1,2]. For the most prominent plasticizer di(2-ethylhexyl)phthalate (DEHP) a high leachability from medical devices, like blood bags and transfusion lines, into blood has been demonstrated [3,4,5]. This may result in a considerable internal exposure of the patients.…”

Section: Introductionmentioning

confidence: 99%

Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its metabolite MEHP during extracorporeal membrane oxygenation (ECMO) therapy

et al. 2020

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The plasticizer di(2-ethylhexyl)phthalate (DEHP) is often used for PVC medical devices, that are also largely used for intensive care medical treatments, like extracorporeal membrane oxygenation (ECMO) therapy. Due to the toxicological potential of DEHP, the inner exposure of patients with this plasticizer is a strong matter of concern as many studies have shown a high leaching potential of DEHP into blood. In this study, the inner DEHP exposure of patients undergoing ECMO treatment was investigated. The determined DEHP blood levels of ECMO patients and the patients of the control group ranged from 31.5 to 1009 μg/L (median 156.0 μg/L) and from 19.4 to 75.3 μg/L (median 36.4 μg/L), respectively. MEHP blood levels were determined to range from < LOD to 475 μg/L (median 15.9 μg/L) in ECMO patients and from < LOD to 9.9 μg/L (median 3.7 μg/L) in the control group patients, respectively. Increased DEHP exposure was associated with the number of cannulas and membranes of the ECMO setting, whereas residual diuresis decreased the exposure. Due to the suspected toxicological potential of DEHP, its use in medical devices should be further investigated, in particular for ICU patients with long-term exposure to PVC, like in ECMO therapy.

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Closing in on DEHP‐free red blood cell concentrate containers

Cited by 6 publications

References 32 publications

Non‐phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags

Non‐phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags

Moderne Methoden der Blutaufbereitung

Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its metabolite MEHP during extracorporeal membrane oxygenation (ECMO) therapy

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