Clostridia in the gut and onset of atopic dermatitis via eosinophilic inflammation

Lee, Eun; Lee, So‐Yeon; Kang, Mi‐Jin; Kim, Kangjin; Won, Sungho; Kim, Byoung-Ju; Choi, Kil Yong; Kim, Bongsoo; Cho, Hyun-Ju; Kim, Yeongho; Yang, Song I; Hong, Soo‐Jong

doi:10.1016/j.anai.2016.04.019

Cited by 67 publications

(72 citation statements)

References 10 publications

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“…The 26 observational studies consisted of 17 prospective cohort studies (13-29) and 9 case-controlled studies (30)(31)(32)(33)(34)(35)(36)(37)(38) (Table I).…”

Section: Observational Studiesmentioning

confidence: 99%

“…Overall, the observational studies were quite heterogenic with regard to study population and bacterial exposure. Five studies found no significant differences in the diversity of gut microbiota in healthy participants compared with patients with AD (13,14,21,30,31). A Danish study including 346 children examined the gut microbiota in infants, but found no association between gut bacterial composition at age 1 month and 12 months and the subsequent development of AD up to the age of 6 years (13).…”

Section: Diversity Of the Gut Microbiota In Patients With Atopic Dermmentioning

confidence: 99%

“…Twenty studies investigated specific bacterial colonization patterns in patients with AD compared with healthy controls (14,19,20,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). The studies examined dif- (27) demonstrated that a higher concentration of Clostridia in the gut microbiota was associated with an increased risk of new onset AD.…”

Section: Specific Gut Bacterial Species and Atopic Dermatitismentioning

confidence: 99%

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Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review

Petersen¹,

Skov²,

Thyssen³

et al. 2018

Acta Derm Venerol

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The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, or by culture. Observational studies were diverse regarding the age of study participants and the bacterial species investigated. Overall, the results were conflicting with regard to diversity of the gut microbiota, specific bacterial colonization, and subsequent risk of AD. Nearly half of the included interventional studies showed that an altered gut microbial colonization due to use of probiotics had a positive effect on the severity of AD. The remaining studies did not show an effect of probiotics on the severity of AD despite an alteration in the gut microbial composition. The role of the gut microbiome for the onset and severity of pre-existing AD remains controversial.

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“…The 26 observational studies consisted of 17 prospective cohort studies (13-29) and 9 case-controlled studies (30)(31)(32)(33)(34)(35)(36)(37)(38) (Table I).…”

Section: Observational Studiesmentioning

confidence: 99%

Section: Diversity Of the Gut Microbiota In Patients With Atopic Dermmentioning

confidence: 99%

Section: Specific Gut Bacterial Species and Atopic Dermatitismentioning

confidence: 99%

See 1 more Smart Citation

Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review

Petersen¹,

Skov²,

Thyssen³

et al. 2018

Acta Derm Venerol

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“…9,[12][13][14] Because the microbiota is linked to immune development and immune responses, it is reasonable to speculate that the microbiome can play an important role in development of allergic diseases. 2,13,[15][16][17] Although differences in the gut microbiota precede the manifestation of allergic disease, causes of the differences in gut microbiota between healthy infants and infants with allergic disease have been difficult to determine because of a number of confounding factors that affect gut microbiome colonization. 12,14,18,19 Feeding type has the greatest influence on colonization of the gut microbiome in early life and can affect the development of AD.…”

mentioning

confidence: 99%

Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type

Lee

Kang

Lee

et al. 2018

Journal of Allergy and Clinical Immunology

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122

101

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“… 44 45 46 Recently, it has been reported that the gut and cutaneous commensal bacteria, including Staphylococcus ( S. ) epidermidis , and S. hominis , play important roles in skin homeostasis and host defense against microbial penetration. 47 48 49 50 …”

Section: Introductionmentioning

confidence: 99%

Significance of Skin Barrier Dysfunction in Atopic Dermatitis

Kim

Leung

2018

Allergy Asthma Immunol Res

271

191

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The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Skin barrier dysfunction is the initial step in the development of AD. Multiple factors, including immune dysregulation, filaggrin mutations, deficiency of antimicrobial peptides, and skin dysbiosis contribute to skin barrier defects. In the initial phase of AD, treatment with moisturizers improves skin barrier function and prevents the development of AD. With the progression of AD, effective topical and systemic therapies are needed to reduce immune pathway activation and general inflammation. Targeted microbiome therapy is also being developed to correct skin dysbiosis associated with AD. Improved identification and characterization of AD phenotypes and endotypes are required to optimize the precision medicine approach to AD.

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Clostridia in the gut and onset of atopic dermatitis via eosinophilic inflammation

Cited by 67 publications

References 10 publications

Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review

Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review

Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type

Significance of Skin Barrier Dysfunction in Atopic Dermatitis

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