Clostridioides difficile-mesocolonic oedema in neonatal suckling piglets develops regardless of the fibre composition in sow’s diets

Influence of high‐ and low‐fermentable dietary fibres in sows' diet on the colostrum potential against Clostridioides difficile toxin‐induced effects in IPEC‐J2 cells

“…Previously, we have determined crude protein and crude fat and lactose content in the study colostrum samples, of which crude protein was elevated in colostrum from SBP‐fed sows and lactose in colostrum from LNC‐fed sows (Grześkowiak et al, 2022a). In addition, we have assessed the colostrum samples for biogenic amines, immunoglobulins and C. difficile toxin‐neutralising IgG antibodies (Grześkowiak et al, 2022a). Here, total biogenic amines were higher in colostrum from sows fed SBP than LNC (Grześkowiak et al, 2022a).…”

“…In addition, we have assessed the colostrum samples for biogenic amines, immunoglobulins and C. difficile toxin‐neutralising IgG antibodies (Grześkowiak et al, 2022a). Here, total biogenic amines were higher in colostrum from sows fed SBP than LNC (Grześkowiak et al, 2022a). Biogenic amines have been reported to influence the intestinal cell proliferation in mice and are essential for the growth and development of the neonatal small intestine (Gómez‐Gallego et al, 2017; Manjarin et al, 2014).…”

“…Different bioactive compounds present in colostrum may be responsible for the observed protective effects (Grześkowiak et al, 2019, 2022a). Previously, we have determined crude protein and crude fat and lactose content in the study colostrum samples, of which crude protein was elevated in colostrum from SBP‐fed sows and lactose in colostrum from LNC‐fed sows (Grześkowiak et al, 2022a).…”

“…Colostrum is a source of essential nutrients and immune cells, which are crucial for the piglet normal development and a resilience to diseases (Sugiharto et al, 2015;Grześkowiak et al, 2018Grześkowiak et al, , 2022a.…”

“…Moreover, its composition can be influenced by the diet fed to sows during gestation and lactation. Specifically, dietary fibre has been shown to modify nutritional (increase in crude protein and biogenic amines) and immunological (reduction in lipopolysaccharide and C‐reactive protein concentrations) composition of colostrum in sows with a consequence on piglet health by for instance increasing IgG‐anti‐lipopolysaccharide in blood serum and decreasing pre‐weaning mortality (Loisel et al, 2013; Werner et al, 2014; Grześkowiak et al, 2022a).…”