Clostridium difficile Disease in a Department of Surgery

Yee, John

doi:10.1001/archsurg.1991.01410260131019

Cited by 64 publications

(26 citation statements)

References 24 publications

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“…For patients with recurrent CDAAD, a history of at least two prior episodes was found to be a significant predictor of subsequent episodes of disease (OR>3.87, 95% Surgery The disruption of intestinal integrity by surgery has CI>1.12, 13.34) [109]. A prior history of AAD caused by other etiologies has not been documented in other frequently been associated with the development of CDAAD, but not non-CDAAD [95,113,124,125]. studies and should be investigated.…”

Section: Prior History Of Aadmentioning

confidence: 99%

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Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea

McFarland

1998

Dig Dis

277

195

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Antibiotic-associated diarrhea (AAD) is a common complication of antibiotics and recent findings on the epidemiology, etiologies and treatment strategies are reviewed. Rates of AAD vary from 5 to 39% depending upon the specific type of antibiotic. The severity of AAD may include uncomplicated diarrhea, colitis or pseudomembranous colitis. The pathogenesis of AAD may be mediated through the disruption of the normal flora and overgrowth of pathogens or through metabolic imbalances. The impact of AAD is reflected by increased hospital stays, higher medical costs and increased rates of comorbidity. The key to decreasing these consequences is prompt diagnosis followed by effective treatment and institution of control measures.

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Section: Prior History Of Aadmentioning

confidence: 99%

“…Even Comorbidity There is no evidence that comorbidity plays a role for short, prophylactic courses of antibiotics given before surgery are sufficient to induce AAD [113,124]. Marts et al non-C. difficile AAD.…”

Section: Prior History Of Aadmentioning

confidence: 99%

Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea

McFarland

1998

Dig Dis

277

195

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“…Risk of CDI can be as high as 8.4% among patients undergoing colorectal, vascular, or cardiothoracic surgery; these patients often receive therapeutic antibiotics in addition to PAP [4][5][6][7][8][9][10][11]. Prior case reports, case series, and small cohort studies restricted their analyses to a single type of intervention.…”

mentioning

confidence: 99%

Risk ofClostridium difficileInfection after Perioperative Antibacterial Prophylaxis before and during an Outbreak of Infection due to a Hypervirulent Strain

Carignan¹,

Allard²,

Pépin³

et al. 2008

CLIN INFECT DIS

151

100

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“…Antibiotics associated with low risk of CDI include aminoglycosides, bacitracin, metronidazole, teicoplanin, rifampin, chloramphenicol, tetracyclines, carbapenems, daptomycin and tigecycline [6]. It is worthy of note that in hospitals with a high incidence of CDI, a single dose of antibiotic given in the framework of perioperative prophylaxis may lead to the development of CDI [14]. …”

Section: Clostridium Difficile Infection In the General Populationmentioning

confidence: 99%

Clostridium Difficile Infection in the Nephrology Ward

Dudzicz¹,

Adamczak²,

Wiȩcek³

2017

Kidney Blood Press Res

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Clostridium difficile is currently the most frequently identified pathogen causing antibiotic-associated diarrhea and the main cause of nosocomial diarrhea. In recent years, increases incidence of infection, severe infection, recurrent infection and mortality from Clostridium difficile infection (CDI) have been observed. This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile. The main risk factors for CDI are: antibiotic therapy, previous hospitalizations and number of comorbid conditions. Prevention of CDI mainly is focused in two directions: reducing the exposure of patients to the disease pathogen by intensifying hygiene measures, and reducing the impact of risk factors. A meta-analyses of clinical studies (observational, cohort and case control) showed significantly higher risk of CDI and CDI recurrence in patients with chronic kidney disease and increased mortality risk in chronic kidney disease patients with CDI comparing those without CDI. Increased risk of CDI in patients with chronic kidney disease can be caused by: frequent antibiotic therapy associated with numerous infections resulting in intestinal microflora dysfunction, frequent hospitalizations, older age of the patients and an impaired immune system. Among preventative measures against CDI, the use of probiotics were also studied. In patients hospitalized in nephrology ward highly significant reduction of the CDI incidence was observed after the introduction of Lactobacillus plantarum 299v as CDI prophylaxis. Therefore, the use of Lactobacillus plantarum 299v seems to be a promising method of CDI prevention in chronic kidney disease patients hospitalized in nephrology ward.

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Clostridium difficile Disease in a Department of Surgery

Cited by 64 publications

References 24 publications

Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea

Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea

Risk ofClostridium difficileInfection after Perioperative Antibacterial Prophylaxis before and during an Outbreak of Infection due to a Hypervirulent Strain

Clostridium Difficile Infection in the Nephrology Ward

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