Clostridium difficile Infection on Rise Among Patients Discharged from Short-Stay Hospitals

McDonald, L. Clifford; Owings, Maria; Jernigan, Daniel B.

doi:10.1097/00132981-200604000-00032

Cited by 233 publications

(330 citation statements)

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“…Predisposing factors to CDI, including increasing age, co-morbidities and use of broad-spectrum antibiotics may be similar across Europe, although exposure to different C. difficile strains likely varies. 1,8 Notably, there was a >40-fold variation in CDI testing frequency across European countries, and a correlation between testing rate and reported infection rate was found. 7 Sub-optimal case ascertainment, either due to inadequate laboratory diagnosis or lack of clinical suspicion means that the true burden of CDI is unclear.…”

Section: Introductionmentioning

confidence: 94%

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)

Davies

Longshaw

Davis

et al. 2014

The Lancet Infectious Diseases

351

309

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Section: Introductionmentioning

confidence: 94%

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)

Davies

Longshaw

Davis

et al. 2014

The Lancet Infectious Diseases

351

309

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“…There have been other disturbing changes in CDI epidemiology. Although considered a nosocomial disease, CDI has also begun to emerge in the community, and in younger individuals who lack the traditional risk factors, often with a higher A C C E P T E D M A N U S C R I P T 5 incidence in females (Aronsson et al, 1985;McDonald et al, 2006;Rupnik et al, 2009). At the same time as this expansion of CDI in humans, there has also been a significant increase in animal disease caused by C. difficile.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Clostridium difficile infection: Evolution, phylogeny and molecular epidemiology

Elliott

Androga

Knight

et al. 2017

Infection, Genetics and Evolution

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Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public health threat. Despite growing attention, C. difficile remains a poorly understood pathogen, however, the exquisite sensitivity offered by next generation sequencing (NGS) technology has enabled analysis of the genome of C. difficile, giving us access to massive genomic data on factors such as virulence, evolution, and genetic relatedness within C. difficile groups. NGS has also demonstrated excellence in investigations of outbreaks and disease transmission, in both small and large-scale applications. This review summarizes the molecular epidemiology, evolution, and phylogeny of C. difficile, one of the most important pathogens worldwide in the current antibiotic resistance era.

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“…The incidence of Clostridium difficile infection (CDI) has increased markedly in the last decade [1,2] and CDI has replaced methicillin-resistant Staphylococcus aureus as the most common cause of healthcare-associated infection [3]. There is also an increasing emergence of more virulent strains of the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Peri‐transplant clostridium difficile infections in patients undergoing allogeneic hematopoietic progenitor cell transplant

et al. 2016

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Clostridium difficile infections (CDI) remain the leading cause of infectious diarrhea among hospitalized patients in this country. Patients with hematologic malignancies, especially those who undergo hematopoietic progenitor cell transplants are particularly at risk for developing CDI. One hundred and forty seven consecutive allogeneic hematopoietic progenitor cell transplants were analyzed for peri-transplant Clostridium difficile infections (PT-CDI). Sixteen patients (11%) developed PT-CDI (Median time 5 7 days after transplant). The probability for developing PT-CDI during the peri-transplant period was 12.3%. History of CDI was strongly associated with the development of PT-CDI (P 5 0.008) (OR 5 5.48) (P 5 0.017). These patients also developed PT-CDI much earlier than in those without a history (median 1 day vs. 8 days, P 5 0.03). The probability for developing PT-CDI for those with a history was 39%. There was a trend toward significance (P 5 0.065) between matched related donor grafts and the development of PT-CDI (OR 5 0.245) (P 5 0.08). Age, sex, diagnosis, transplant preparative regimens, Graft-versus-host disease (GVHD) prophylaxis, grade 3/4 acute GVHD, or use of antimicrobials within 8 weeks of transplant were not associated with PT-CDI. Non-CDI-related deaths occurred in one patient in the PT-CDI group and nine in the group without PT-CDI. In the remaining 139 patients, the length of hospital stay for those with PT-CDI was significantly longer than those without (mean 27 days vs. 22 days; P 5 0.02).

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Clostridium difficile Infection on Rise Among Patients Discharged from Short-Stay Hospitals

Cited by 233 publications

References 0 publications

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)

Clostridium difficile infection: Evolution, phylogeny and molecular epidemiology

Peri‐transplant clostridium difficile infections in patients undergoing allogeneic hematopoietic progenitor cell transplant

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