Clostridium septicum sepsis and colorectal cancer - a reminder

Mirza, Nazzia; McCloud, J.M.; Cheetham, Mark

doi:10.1186/1477-7819-7-73

Cited by 73 publications

(60 citation statements)

References 16 publications

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“…Interestingly, blood sample was obtained before colonoscopy and it is suggested that these microorganisms were able to achieve bloodstream through tumor tissue and they may remain in state of bacteremia for long period [6]. In this case, the infection in rectal cancer involves disruption of the normal barrier due to tumor-induced ulceration, followed by bloodstream invasion, in accordance with Mirza [7] Bacteremia caused by anaerobic bacteria represents from 0.5% to 12% of the total of bacteremia, and the mortality is approximately between 25% and 44% [8]. Studies have shown that bacterial community in an individual is relatively stable along the distal digestive tract [9].…”

Section: Discussionmentioning

confidence: 91%

Bloodstream Infection due to Bacterial Co-Infection in Patients with Rectal Carcinoma: Report of Two Cases

Solis-Castro¹,

Alberca²,

Freire³

et al. 2017

Colorec Cancer

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In this study, we reported the bacterial co-infection causing bacteremia in two of 38 patients diagnosed with rectal carcinoma. 10 mL of blood of each patient were cultured in BHI broth. From positive blood cultures, aliquots were streaked on MacConkey agar (aerobiosis), and Bacteroides-bile-esculin agar and kanamycinblood agar (anaerobiosis). Bacteria were identified by using API-20A kit and confirmed by 16s rDNA sequencing. The bacterial identification showed the presence of Escherichia coli, Bacteroides fragilis and Enterococcus faecalis. The use of DNA sequencing showed to be a tool for rapid screening of blood infections than the classic microbiological methods, and provides an accurate and effective microbial identification in sepsis process. Patients with intestinal malignancy can produce bacteremia with nonspecific or atypical symptoms.

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Section: Discussionmentioning

confidence: 91%

Bloodstream Infection due to Bacterial Co-Infection in Patients with Rectal Carcinoma: Report of Two Cases

Solis-Castro¹,

Alberca²,

Freire³

et al. 2017

Colorec Cancer

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“…Moreover, recurrent infections may occur in both CRC and aplastic anemia. Streptoccocusbovis septicemia is classically associated with colorectal cancer [11] ; other organisms include Enterobacter [12] and Clostridium species [13] . Infections that are seen in aplastic anemia also include Streptoccocus and Clostridium species, in addition to Escherichia coli and others [14] .…”

Section: Discussionmentioning

confidence: 99%

Coloncancer in a patient with underlying aplastic anemia: A clinical challenge

Wong

Chan²,

Yau³

2012

WJCO

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The association of gastrointestinal malignancy with aplastic anemia has rarely been reported in the literature. Although it is not clear whether there is any direct relationship between aplastic anemia and gastrointestinal cancers, a retrospective analysis did suggest the notion that patients with aplastic anemia might have a higher incidence of colorectal cancer. Here, we report the diagnostic and therapeutic challenges in managing a patient with aplastic anemia and advanced colorectal cancer. Early diagnosis is challenging due to overlapping symptomatology and clinical features, increased risk of diagnostic procedures, and confounding complications arising from aplastic anemia and its treatment. A high index of suspicion and multidisciplinary input are essential.

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“…In addition to S. gallolyticus endocarditis, also Clostridium septicum infections have been clinically associated with sporadic CRC (Chew & Lubowski, 2001;Mirza et al, 2009). C. septicum is not considered to be part of the normal intestinal microbiota and is a rare cause of bacteremia (<1% of all cases).…”

Section: Clostridium Septicummentioning

confidence: 99%