Clostridium tertium in neutropenic patients: case series at a cancer institute

Shah, Sweta; Hankenson, Jennifer; Pabbathi, Smitha; Greene, John N.; Nanjappa, Sowmya

doi:10.1016/j.ijid.2016.08.013

Cited by 12 publications

(19 citation statements)

References 17 publications

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“…Clostridium tertium is an anaerobic gram-positive bacterium in the phylum Firmicutes. Although C. tertium has traditionally been considered non-pathogenic, various studies have reported it to be a significant cause of bacteremia and other infections in neutropenia patients [29,49,50,53,60]. In addition, C. tertium infections in non-neutropenic patients have also been reported recently [57,58,62].…”

Section: Discussionmentioning

confidence: 99%

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)

Sun

Dai

et al. 2021

BMC Microbiol

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Background Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Results In total, 56 mucosal microbiome samples were collected from 28 Chinese UC patients and their healthy family partners, followed by amplicon sequencing. Based on sequencing data, we analyzed species diversity, shared species, and inter-species interactions at the whole community, main phyla, and core/periphery species levels. We identified four opportunistic “pathogens” (i.e., Clostridium tertium, Odoribacter splanchnicus, Ruminococcus gnavus, and Flavonifractor plautii) with potential significance for the diagnosis and treatment of UC, which were inhibited in healthy individuals, but unrestricted in the UC patients. In addition, we also discovered in this study: (i) The positive-to-negative links (P/N) ratio, which measures the balance of species interactions or inhibition effects in microbiome networks, was significantly higher in UC patients, indicating loss of inhibition against potentially opportunistic “pathogens” associated with dysbiosis. (ii) Previous studies have reported conflicting evidence regarding species diversity and composition between UC patients and healthy controls. Here, significant differences were found at the major phylum and core/periphery scales, but not at the whole community level. Thus, we argue that the paradoxical results found in existing studies are due to the scale effect. Conclusions Our results reveal changes in the ecology and network structure of the gut mucosal microbiome that might be associated with UC, and these changes might provide potential therapeutic mechanisms of UC. The four opportunistic pathogens that were identified in the present study deserve further investigation in future studies.

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Section: Discussionmentioning

confidence: 99%

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)

Sun

Dai

et al. 2021

BMC Microbiol

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“…A C. tertium infection usually presents as fever and gastrointestinal complaints, such as abdominal pain, rectal bleeding, nausea, diarrhea, or constipation. Some patients with a C. tertium infection can be completely asymptomatic [5] while immunocompromised patients can have septicemia.…”

Section: Discussionmentioning

confidence: 99%

“…Shah et al conducted a retrospective review of patients with C. tertium bacteremia at H. Lee Moffitt Cancer Center and Research Institute from 2005 to 2015 and found that only seven patients were diagnosed in this 10-year period. All patients were neutropenic: five had acute myeloid leukemia and two had myelodysplastic syndrome [5]. Despite the clearance of blood cultures in all seven cases within three days of antibiotic therapy, five patients died within four months of C. tertium bacteremia.…”

Section: Discussionmentioning

confidence: 99%

Clostridium tertium Bacteremia in a Non-neutropenic Patient with Liver Cirrhosis

Wazir

Jain

Nadeem

et al. 2019

Cureus

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“…Colonization by C. paraputrificum is mainly associated with myonecrosis and bacteremia in humans although a wide range of invasive infections can also occur [13], and this pathogen was recently found to be the fortuitous cause of necrotizing cellulitis of the abdominal wall in one individual [14]. C. tertium is associated with bacteremia cases [15] and septic shock [16], but it mainly infects immunocompromised [17] and neutropenic patients [18]. This species has recently been identified as a causal agent of necrotizing fasciitis and gangrene [19], and is also known to cause various pathologies in non-neutropenic patients [20].…”

Section: Introductionmentioning

confidence: 99%

Comparative genomics identifies potential virulence factors inClostridium tertiumandC. paraputrificum

et al. 2019

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Some well-known Clostridiales species such as Clostridium difficile and C. perfringens are agents of high impact diseases worldwide. Nevertheless, other foreseen Clostridiales species have recently emerged such as Clostridium tertium and C. paraputrificum . Three fecal isolates were identified as Clostridium tertium (Gcol.A2 and Gcol.A43) and C. paraputrificum (Gcol.A11) during public health screening for C. difficile infections in Colombia. C. paraputrificum genomes were highly diverse and contained large numbers of accessory genes. Genetic diversity and accessory gene percentage were lower among the C. tertium genomes than in the C. paraputrificum genomes. C. difficile tcdA and tcdB toxins encoding homologous sequences and other potential virulence factors were also identified. EndoA interferase, a toxic component of the type II toxin-antitoxin system, was found among the C. tertium genomes. toxA was the only toxin encoding gene detected in Gcol.A43, the Colombian isolate with an experimentally-determined high cytotoxic effect. Gcol.A2 and Gcol.A43 had higher sporulation efficiencies than Gcol.A11 (84.5%, 83.8% and 57.0%, respectively), as supported by the greater number of proteins associated with sporulation pathways in the C. tertium genomes compared with the C. paraputrificum genomes (33.3 and 28.4 on average, respectively). This work allowed complete genome description of two clostridiales species revealing high levels of intra-taxa diversity, accessory genomes containing virulence-factors encoding genes (especially in C. paraputrificum ), with proteins involved in sporulation processes more highly represented in C. tertium . These finding suggest the need to advance in the study of those species with potential importance at public health level.

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Clostridium tertium in neutropenic patients: case series at a cancer institute

Cited by 12 publications

References 17 publications

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)

Clostridium tertium Bacteremia in a Non-neutropenic Patient with Liver Cirrhosis

Comparative genomics identifies potential virulence factors inClostridium tertiumandC. paraputrificum

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