Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts

Abstract

The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of Ficus glomerata, a traditional medicinal plant, using an in vitro assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with the negative control (sterile distilled water). The extracts have shown mild clot lysis, that is, 2.16%, 23.06%, 27.60%, and 47.74% of sterile distilled water, FGPE, FGCE, and FGME, respectively, while the standard (streptokinase) has shown 74.22% clot lysis. FGME inhibited the root growth in number as well as length effectively, followed by FGPE, while FGCE exhibited moderate antimitotic activity and it was supported by mitotic index. Therefore, the obtained results suggest that among all the extracts of plant the methanolic extract has shown highest thrombolytic and antimitotic activity.

Thrombolytic Activity of C.AMADA and C.CAESIA

“…Statistical analysis revealed that the rhizome extracts have a significant percentage of clot lysis when compared with positive and negative control. As the first generation drugs (SK and UK), found to cause side effects [17], plant-based thrombolytic drugs will improve the treatment of thrombosis. Therefore, in-vivo study of C. amada and C. caesia is further needed, to be recognized as a thrombolytic agent.…”

Qualitative phytochemical screening and in vitro thrombolytic activity of Capparis decidua Edgew. Fruit

“…In addition to the presence of phytochemicals, C. decidua fruits were also found to possess thrombolytic efficacy as shown in Table 2. Several plant species have been screened for in vitro thrombolytic potential [13,21] and some of the plants have shown similar in vitro percent thrombolytic potential for example, 32.58% clot lysis activity by leaves of Leea indica [22], 31.61% by leaves of Senna sophera and 31.51% fruits of Solanum torvum [23], 23.11% by chloroform extract of fruits of Ficus glomerata [24], 30.17% and 22.53% clot lysis by bark and seeds of Tamarindus indica respectively [25], 32.94% by seeds of Sesamum indicum [26], etc.…”

A Study on Thrombolytic and Cytotoxic Activity of Methanolic Extract of Zingiber Officinale

“…Statistical analysis revealed that the rhizome extracts have a significant percentage of clot lysis when compared with positive and negative control. As the first generation drugs (SK and UK), found to cause side effects 12,13 , plant-based thrombolytic drugs will improve the treatment of thrombosis. The methanolic leaf extract of Euphorbia hirta have maximum activity for lysing the clot.…”