Objective: To compare the thrombolytic activity of Curcuma amada and Curcuma caesia.Methods: Hydroalcoholic extractions of C. amada and C. caesia were prepared. Clot lysis potential of the extracts was checked, and the results were statistically analyzed. Results and Conclusion:On comparing the thrombolytic potential, the percentage of clot lysis of synthesized silver nanoparticle using C. caesia (51%) was found to be higher than C. amada (34.7%) extract. Similarly, C. caesia extract (38.75±2.217) showed higher percentage of clot lysis than C. amada (34.74±6.074). The mean percentage of clot lysis of rhizome extracts and synthesized silver nanoparticle was statistically more significant (p<0.05) when compared to the positive control streptokinase and negative control water. Active component involvement analysis will be helpful to utilize the C. amada and C. caesia as potent therapeutic agent.

A biofilm may be a consortium of micro-organisms in which the cells of microbes attach to each other on a living or non-living surface inside a self-produced matrix of extracellular polymeric substances. The bacterial or fungal colonies invade the surface of the wounds, thereby delaying the healing cascade. The resistance is partially due to low metabolic rate of these colonies, which directly impacts the action of oral or parenteral antibiotics. Hence, there is an urgent need to develop antibacterial agents to regulate the biofilm growth and development. The last few decades have witnessed wide research studies attempting to investigate the anti-biofilm effects of natural products. This review will summarize the wound infections associated with biofilm, mechanisms of bacterial resistance due to biofilm and recent studies on discovery of natural products with their mechanisms for inhibiting various bacterial biofilms that can be a promising candidate which could provide novel strategies for biofilm-associated infections.