Clot retraction

Antimotility Effect of Cytochalasin B Observed in Mammalian Clot Retraction

“…We demonstrated that the mammalian platelet and nonmammalian thrombocyte contractile mechanism as seen in clot retraction is remarkably similar to the contractile systems controlling biological movement described for other cells (3), and a theoretical model for contractile microfiber formation in platelets was postulated (4) . Recently, we described in glycerinated platelets the complexing of a 60 A diameter microfiber with heavy meromyosin that produced a distinct arrowhead pattern similar to that described for muscle actin or with microfibers from nonmuscle cells (5) .…”

XXIVth Scientific Meeting of the Blood Research Institute

“…If this is true, the disappearance of labeled platelets and the failure to induce a rise in platelet count could be interpreted in two ways : (1) a poor survival or (2) a better in vivo utilization. Platelet counts from the influx and the outflux of an isolated organ perfusion system [28] The kinetic studies on clot retraction [30] showed that the retraction rate is most rapid during the first 30 minutes after clotting and then ap proaches a plateau. The measurement of the early phase of clot retraction, when the energy requirement is maximum, appears to be a better test for platelet energy state than the conventional method of measurement at 1-hour postclotting when retraction already has reached the plateau.…”