Clozapine-induced interstitial nephritis - a rare but important complication: a case report

Hunter, Robert; Gaughan, Tracey; Queirazza, Filippo; McMillan, Dina; Shankie, Susan

doi:10.1186/1752-1947-0003-0000008574

Cited by 18 publications

(15 citation statements)

References 10 publications

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“…Recently, a few cases of clozapine-induced acute renal interstitial nephritis have been reported in the western countries but not in Korea 2-4. We report a case of acute renal failure developed just after initiation of clozapine for the treatment of mood symptom in a young male patient.…”

Section: Introductionmentioning

confidence: 83%

A Case of Clozapine Induced Acute Renal Failure

Lee

Noh

2013

Psychiatry Investig

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There have been a few case reports that clozapine, an atypical antipsychotic, caused acute renal failure of interstitial type. Here we report a case of a 38-year-old Korean male patient with treatment-resistant bipolar I disorder who developed acute renal failure after the initiation of treatment with clozapine. We describe the clinical and laboratory findings of the case and discuss the measures for early detection of this life threating condition. Within our knowledge, this is the first report of clozapine-induced acute renal failure in South Korea.

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Section: Introductionmentioning

confidence: 83%

A Case of Clozapine Induced Acute Renal Failure

Lee

Noh

2013

Psychiatry Investig

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“…Healthcare products Regulatory Agency (n=26,000), 10 were of acute interstitial nephritis and 31 of acute renal failure, 35 indicating that it is a low prevalence event, which is indicated by the low number of cases identified in our review.…”

Section: Of Suspected Clozapine Adverse Events Reported To the Unitedmentioning

confidence: 85%

“…We identified 20 cases of clozapine induced hepatitis, 11-30 11 cases of nephritis, [31][32][33][34][35][36][37][38][39][40][41]…”

Section: Demographic and Clinical Characteristics Of All Included Casmentioning

confidence: 99%

“…Seven of the cases underwent a clozapine rechallenge (hepatitis n=3, 11,12,15 nephritis n=1 35 , pancreatitis n=3 45,50,51 ). Five of the cases had a recurrence of the incident inflammatory disorder, at a mean onset of 3.5 (SD=2.5) days (range=1-7 days) which was significantly shorter than those who were treated with clozapine for the first time (mean=27.0 (SD=19.0) days (range=0-90 days)) (t=-2.418, p<0.019).…”

Section: Clozapine Rechallengementioning

confidence: 99%

“…In this 25 year old, there was a recurrence of nephritis, with fever, tachycardia, markedly raised CRP (197 mg/L) and a rising creatinine, all occurring within 3 days of clozapine (dose 25mg/day) rechallenge. 35…”

Section: Rechallenge Following Clozapine Associated Nephritismentioning

confidence: 99%

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Hepatitis, Interstitial Nephritis, and Pancreatitis in Association With Clozapine Treatment

Lally¹,

Kalbani

Krivoy³

et al. 2018

J Clin Psychopharmacol

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Clozapine-induced hepatitis, nephritis, and pancreatitis are uncommon adverse events, reflected in the paucity of case studies in the literature. Early recognition of the signs and symptoms of clozapine-associated hepatitis, nephritis, and pancreatitis is important, as when identified, clozapine should be urgently discontinued. Clozapine is associated with evidence of benign inflammatory processes; the extent to which hepatitis, and other inflammatory reactions, may be on a continuum with these more benign and self-limiting reactions is unclear, and this can only be resolved by prospectively following cohorts of clozapine-treated patients.

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Schizophrenia and Related Psychoses

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Despite disagreements about nomenclature, patients who develop schizophrenic or schizophrenialike symptoms in later life are often seen in clinical practice. Questions about the etiology of late-life psychotic disorders and about their similarities or differences from early-onset disorders remain unanswered. Neuroimaging techniques have been used to study patients with late onset of psychosis, and in substantial subgroups of patients (from 25% to 100% in various studies) compared with agematched control subjects, structural and functional abnormalities have been found. We review the literature on imaging in late-life schizophrenia and related psychotic disorders, and we present data from our own investigations of patients with these disorders. We discuss the potential usefulness of imaging evaluations in patients with late-onset disorders, and we offer suggestions for future investigations.

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Clozapine-induced interstitial nephritis - a rare but important complication: a case report

Cited by 18 publications

References 10 publications

A Case of Clozapine Induced Acute Renal Failure

A Case of Clozapine Induced Acute Renal Failure

Hepatitis, Interstitial Nephritis, and Pancreatitis in Association With Clozapine Treatment

Schizophrenia and Related Psychoses

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