Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers

Garcia, Giancarlo A.; Tian, Jun-Ru; Apinyawasisuk, Supanut; Kim, Sarah; Akıl, Handan; Sadun, Alfredo A.

doi:10.1016/j.joco.2016.07.008

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…Association of extensive bilateral myelinated nerve fibers around the optic disc has been described by Garcia et al . [ 28 ] in a case of Crouzon syndrome. The role of FGFR-2 has been defined in oligodendrocyte growth[ 29 ] and overactivation of FGFR-2 has been linked to abnormal regulation of myelination.…”

Section: Methodsmentioning

confidence: 99%

Crouzon syndrome and the eye: An overview

Bhattacharjee

Rehman²,

Venkatraman³

et al. 2022

Indian Journal of Ophthalmology

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The current literature review aims to evaluate the ocular findings and associated ophthalmic features in Crouzon syndrome. Craniosynostoses are syndromes characterized by premature fusion of sutures of the skull and Crouzon syndrome is the most common of the craniosynostosis syndromes. Early fusion of sutures results in craniofacial anomalies, including abnormalities of the orbits. To prepare this review of the ophthalmic findings in this disorder, an organized search on online databases such as PubMed, Scopus, Cochrane Library, and Ovid was carried out. The key terms searched were “Crouzon”, “craniosynostosis”, “eye” and “ophthalmic”, and 51 research items were found. A total of 17 articles were included after scrutiny of the databases and a further 25 articles were added after augmented search. A detailed review was performed from the final 42 articles. A comprehensive description of associated anomalies is given along with the author’s own technique of surgical management in cases with Crouzon syndrome having bilateral luxation bulbi with exposure keratopathy. However, for optimum management of cranial and oculo-facial dysmorphisms, a multidisciplinary team of specialists is required.

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Section: Methodsmentioning

confidence: 99%

Crouzon syndrome and the eye: An overview

Bhattacharjee

Rehman²,

Venkatraman³

et al. 2022

Indian Journal of Ophthalmology

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“…Despite constant upgrades in software, the motion artifacts are still limiting the use of the instrument in older patients and children with poor cooperation as they have to fixate their eyes for some time [ 22 ]. Moreover, presence of epiretinal lesions such as myelinated fibers may also obscure the images [ 69 ]. Studies conducted in animal models show that injecting contrast agents that are more symmetrically shaped than the erythrocytes allows us to observe images with less artifacts as some of the artifacts are inherent to the method of detecting erythrocytes [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Principles of OCTA and Applications in Clinical Neurology

Wylęgała

2018

Curr Neurol Neurosci Rep

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Purpose of ReviewThe article reviews the recent findings on the use of optical coherence tomography angiography (OCTA) in neurology.Recent FindingsOCTA is a new addition to the powerful and complementary technology of the OCT. Due to its noninvasiveness, and reproducibility, it is possible to obtain high-resolution 3D images of the vessels of the human eye. As the vessels of the retina with the presence of endothelial cell’s tight junctions resemble the brain vessels, it was hypothesized that the imaging of the retinal vessels might bring insight into brain vessels. OCTA has been effectively used to predict retinal vessel abnormalities in dementia, demyelization, optic disc neuropathies, and inherited degenerative diseases. Most common findings were decrease of vascular density and flow and an increase of avascular zones.SummaryAlthough OCTA is a relative new technology, recent studies show that it can be successfully applied in neurology.

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“…Recently, a case of bilateral extensive peripapillary MNF has been reported in a patient with Crouzon syndrome, an inherited form of craniosynostosis caused by over-activation of fibroblast growth factor receptor 2 [16].…”

Section: Myelinated Nerve Fibersmentioning

confidence: 99%

Optic Nerve: Developmental Anomalies and Common Tumors

Alkatan¹,

Alshowaeir²,

Alzahem³

2019

Optic Nerve

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The optic nerve, also known as the second cranial nerve, is composed of axons that transmit visual information from the neurosensory retina to the visual cortex. There are multiple pathologies that can affect the human optic nerve. Congenital anomalies of the optic nerve include myelinated nerve fibers, morning glory syndrome, optic nerve choristoma, optic nerve coloboma, optic nerve hypoplasia and aplasia, and others. Tumors that can affect the optic nerve (ON) may occur primarily from within the nerve itself, from the surrounding optic nerve sheath (ONS), or secondarily spreading to the nerve from a distant site. They include optic pathway glioma, medulloepithelioma, oligodendroglioma, optic nerve sheath meningioma, and others. Here in this chapter, we will review the optic nerve anatomy, embryology, and physiology in addition to assessment of optic nerve function. Moreover, the clinical features, imaging findings, pathology, and treatment options of the most common and some rare congenital anomalies and primary tumors of the ON and sheath will be reviewed.

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Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers

Cited by 13 publications

References 25 publications

Crouzon syndrome and the eye: An overview

Crouzon syndrome and the eye: An overview

Principles of OCTA and Applications in Clinical Neurology

Optic Nerve: Developmental Anomalies and Common Tumors

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