Clues to cancer etiology from studies of farmers.

Blair, Aaron; Zahm, Shelia Hoar; Pearce, Neil; Ef, Heineman; Fraumeni, Joseph F.

doi:10.5271/sjweh.1578

Cited by 342 publications

(261 citation statements)

References 55 publications

Supporting

Mentioning

231

Contrasting

Unclassified

Order By: Relevance

“…Several studies suggest chlorpyrifos or chlorpyrifos-methyl may be hormonally active but specific findings have not been fully consistent. Chlorpyrifos and other organophosphates have been shown to inhibit steroidogenesis in adrenal cells (37,38), and chlorpyrifos potently affected GnRH gene expression and biosynthesis in vitro (18). Weak responses to chlorpyrifos were reported in two in vitro estrogenicity assays (19), whereas chlorpyrifos-methyl exhibited antiandrogenic activity, but not estrogenic or estrogen-like activity, in immature rats (20).…”

Section: Discussionmentioning

confidence: 99%

Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Meeker

Ravi

Barr

et al. 2008

Reproductive Toxicology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Meeker

Ravi

Barr

et al. 2008

Reproductive Toxicology

View full text Add to dashboard Cite

show abstract

“…This cohort was established to evaluate findings from previous studies that suggested that farmers may be at elevated risk for a few cancers. 16 Recruitment of the cohort occurred between 1993 and 1997. 17 Cohort members were matched to cancer registry files in Iowa and North Carolina for case identification and to the state death registries and the National Death Index to ascertain vital status.…”

Section: Cohort Enrollment and Follow-upmentioning

confidence: 99%

Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study

Rusiecki

Hou

Lee

et al. 2006

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Metolachlor is one of the most widely used herbicides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to metolachlor in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. A total of 50,193 pesticide applicators were included. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997; average length of follow-up was 7.33 years. Two metolachlor exposure metrics were used : (i) lifetime days personally mixed or applied metolachlor and (ii) intensity-weighted lifetime days (lifetime days 3 an intensity level). Poisson regression analysis was used to estimate relative risks (RR) and 95% confidence intervals (95%CI) for cancer subtypes by tertiles of metolachlor exposure. No clear risk for any cancer subtype was found for exposure to metolachlor. A significantly decreased RR was found for prostate cancer in the highest category of lifetime days exposure (RR 5 0.59; 95%CI, 0.39-0.89) and in the second highest category of intensity-weighted lifetime days exposure (RR 5 0.66; 95%CI, 0.45-0.97); however, the test for trend was not significant for either exposure metric. A nonsignificantly increased risk was found for lung cancer with lifetime days exposure in the highest category (RR 5 2.37; 95%CI, 0.97-5.82, p-trend 5 0.03) but not with intensity-weighted lifetime days. Given the widespread use of metolachlor and the frequent detection of metolachlor in both surface and ground water, future analyses of the AHS will allow further examination of long-term health effects, including lung cancer and the less common cancers. ' 2006 Wiley-Liss, Inc.

show abstract

“…Many epidemiological studies have suggested the possible role of pesticides in the occurrence of cancers (Blair et al, 1992;Dich et al, 1997;Acquavella et al, 1998), neurological diseases (Colosio et al, 2003) or reproductive disorders (Cocco, 2002). Exposure assessment represents a critical concern in these studies Zahm, 1990, 1993;Garcia et al, 2000;Hamey, 2001).…”

Section: Introductionmentioning

confidence: 99%

Pesticide contamination of workers in vineyards in France

Baldi¹,

Lebailly

Jean³

et al. 2005

J Expo Sci Environ Epidemiol

109

View full text Add to dashboard Cite

In order to build tools to quantify exposure to pesticides of farmers included into epidemiological studies, we performed a field study in Bordeaux vineyards during the 2001 and 2002 treatment seasons to identify parameters related to external contamination of workers. In total, 37 treatment days were observed in tractor operators corresponding to 65 mixing operations, 71 spraying operations and 26 equipment cleaning. In all, four operators with backpack sprayers and seven re-entry workers were also monitored. We performed both detailed observations of treatment characteristics on the whole day and pesticide measurements of external contamination (dermal and inhalation) for each operation. The median dermal contamination was 40.5 mg of active ingredient per day for tractor operators, 68.8 mg for backpack sprayers and 1.3 mg for vineyard workers. Most of the contamination was observed on the hands (49% and 56.2% for mixing and spraying, respectively). The median contribution of respiratory route in the total contamination was 1.1%. A cleaning operation resulted in a 4.20 mg dermal contamination intermediate between a mixing (2.85 mg) and a spraying operation (6.13 mg). Farm owners experienced higher levels than workers and lower contaminations were observed in larger farms. The contamination increased with the number of spraying phases and when equipment cleaning was performed. Types of equipment influenced significantly the daily contamination, whereas personal protective equipment only resulted in a limited decrease of contamination.

show abstract

Clues to cancer etiology from studies of farmers.

Cited by 342 publications

References 55 publications

Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study

Pesticide contamination of workers in vineyards in France

Contact Info

Product

Resources

About