At present, the issue ecological balance restoring and rational resource con-sumption is especially acute, which determines large-scale transformations at the world level, as well as the need to modernize the tools for socio-economic develop-ment systems of countries (macro-level), individual territories and regions (meso-level), a set of interacting economic systems and economic units (microlevels). The article examines the problems of responsible resource consumption in regional socioeconomic systems, which led to change of effective growth paradigm to: 1) the sustainable development paradigm, society’s informatization; 2) selective regional policy of interregional differentiation. Obviously, at the macro-level, there is an intensive search for effective management of regional resource consumption; development of mechanisms and tools for environmental responsibility management. That is why a decrease in the level of negative impacts, as well as the consequences of low socio-economic development, determines the genesis of responsible resource consumption tools in regions’ strategizing as a key development task. However, the study of the ontology “responsible resource consumption tools” goes through the concept of sustainable development and is transformed into an integral, logically linked system of views, united by a common idea and aimed at achieving the goal of work.