Cluster calibration in mass spectrometry: laser desorption/ionization studies of atomic clusters and an application in precision mass spectrometry

Blaum, Klaus; Herlert, A.; Huber, G.; Kluge, H.‐J.; Maul, J.; Schweikhard, L.

doi:10.1007/s00216-003-2168-7

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…Recently, we showed that flower-like AuNPs deposited on the target plate enhance the ionization of peptides [17]. We were curious whether the gold clusters generated by highenergy LDI could be used for the internal calibration of biomolecules such as small peptides or even proteins.…”

Section: Gold Clusters (Au N +/-)mentioning

confidence: 99%

“…Clusters of monoisotopic elements provide simple spectra with many monoisotopic peaks covering the mass range of interest with regular mass spacing. In this work, we discuss the calibration of mass spectra by clusters of red phosphorus, which is already established in our laboratory [6,[10][11][12][13][14][15][16], and compare it with calibration by gold clusters generated directly on the target by laser desorption ionization (LDI)-MS of various materials, including gold foil [17], various types of gold nanoparticles (AuNPs), chloroauric acid (HAuCl 4 ), a mixture of 2-(4-hydroxyphenylazo) benzoic acid and HAuCl 4 [18], and polyvinylpyrrolidone-stabilized AuNPs [19]. Gold clusters provide simple and fast determination of accurate mass compared with common calibration standards, such as peptides or proteins.…”

Section: Introductionmentioning

confidence: 99%

“…Although the possibility of using gold clusters in negative ion mode (up to m/z 10,000) for the calibration of large biomolecules [17] has already been suggested, the experimental application of gold clusters for the calibration of TOF MS or quadrupole ion trap (QIT)-TOF MS has not yet been published.…”

Section: Introductionmentioning

confidence: 99%

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Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Kolářová

Prokeš

Kučera

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. Precise calibration in TOF MS requires suitable and reliable standards, which are not always available for high masses. We evaluated inorganic clusters of the monoisotopic elements gold and phosphorus (Au n + /Au n -and P n + /P n -) as an alternative to peptides or proteins for the external and internal calibration of mass spectra in various experimental and instrumental scenarios. Monoisotopic gold or phosphorus clusters can be easily generated in situ from suitable precursors by laser desorption/ionization (LDI) or matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Their use offers numerous advantages, including simplicity of preparation, biological inertness, and exact mass determination even at lower mass resolution. We used citrate-stabilized gold nanoparticles to generate gold calibration clusters, and red phosphorus powder to generate phosphorus clusters. Both elements can be added to samples to perform internal calibration up to mass-to-charge (m/z) 10-15,000 without significantly interfering with the analyte. We demonstrated the use of the gold and phosphorous clusters in the MS analysis of complex biological samples, including microbial standards and total extracts of mouse embryonic fibroblasts. We believe that clusters of monoisotopic elements could be used as generally applicable calibrants for complex biological samples.

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Section: Gold Clusters (Au N +/-)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Kolářová

Prokeš

Kučera

et al. 2016

J. Am. Soc. Mass Spectrom.

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“…TRIGA-TRAP will carry out absolute mass measurements by using carbon clusters as mass references [83,84]. Clusters up to C þ 23 were produced in pilot measurements with a MALDI-TOF system [63].…”

Section: Absolute Mass Measurements and Heavy-ion Productionmentioning

confidence: 99%

TRIGA-SPEC: A setup for mass spectrometry and laser spectroscopy at the research reactor TRIGA Mainz

Ketelaer

Krämer

Beck³

et al. 2008

Nuclear Instruments and Methods in Physics Research Section A:

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119

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The research reactor TRIGA Mainz is an ideal facility to provide neutron-rich nuclides with production rates sufficiently large for mass spectrometric and laser spectroscopic studies. Within the TRIGA-SPEC project, a Penning trap as well as a beamline for collinear laser spectroscopy are being installed. Several new developments will ensure high sensitivity of the trap setup enabling mass measurements even on a single ion. Besides neutron-rich fission products produced in the reactor, also heavy nuclides such as 235U or 252Cf can be investigated for the first time with an off-line ion source. The data provided by the mass measurements will be of interest for astrophysical calculations on the rapid neutron-capture process as well as for tests of mass models in the heavy-mass region. The laser spectroscopic measurements will yield model-independent information on nuclear ground-state properties such as nuclear moments and charge radii of neutron-rich nuclei of refractory elements far from stability. TRIGA-SPEC also serves as a test facility for mass and laser spectroscopic experiments at SHIPTRAP and the low-energy branch of the future GSI facility FAIR. This publication describes the experimental setup as well as its present status

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“…In this context, carbon clusters provide the reference mass of choice. 33 The advantages are obvious: a multitude of reference masses all over the nuclear chart are available which are, at most, six atomic mass units away from any nuclide of interest (see Figure 5). Thus, any systematic mass dependent uncertainty which increases with the difference between the measured mass and the reference mass is minimized.…”

Section: Isoltrap: Carbon Clusters In Precision Mass Spectrometrymentioning

confidence: 99%

Atomic Clusters and Ion Cyclotron Resonance Mass Spectrometry: A Fruitful Combination

Schweikhard

Blaum

Herlert

et al. 2005

Eur J Mass Spectrom (Chichester)

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Clusters consisting of a few atoms build the bridge between individual atoms and the condensed phase of matter and they are, thus, of great general interest. Over the last two decades, considerable progress has been made in the study of their properties and ion storage techniques, in particular the use of ion cyclotron resonance (Penning) traps, are important tools for advanced investigations. Vice versa, cluster ions can serve as probes for the evaluation of ion-trap properties. Furthermore, they are ideally suited for the calibration of mass spectrometers and for consistency checks in high-accuracy mass determinations. Examples from the research areas mentioned, i.e. the investigation of cluster properties and the application of cluster ions for Penning-trap studies and mass calibration, are reported.

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Cluster calibration in mass spectrometry: laser desorption/ionization studies of atomic clusters and an application in precision mass spectrometry

Cited by 22 publications

References 31 publications

Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

TRIGA-SPEC: A setup for mass spectrometry and laser spectroscopy at the research reactor TRIGA Mainz

Atomic Clusters and Ion Cyclotron Resonance Mass Spectrometry: A Fruitful Combination

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