Cluster of two cases of botulism due to Clostridium baratii type F in France, November 2014

Castor, C.; Mazuet, Christelle; Saint-Leger, M; Vygen, Sabine; Coutureau, J; Durand, Maurice P.; Popoff, Michel R.; Silva, N Jourdan Da

doi:10.2807/1560-7917.es2015.20.6.21031

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…The three cases reported here presented with severe symptoms and rapid progression towards respiratory failure and quadriplegia, although of shorter duration compared with C. botulinum-related botulism [4]. These clinical signs are similar to those described for type F botulism cases [1][2][3][4][5][6][7][8]. A high level of protein in the CSF has also been described with botulism [7,9], which could lead to misdiagnosis.…”

Section: Discussionsupporting

confidence: 71%

“…This is the second C. baratii type F botulism outbreak in France in less than one year [2,3]. Given that strains are centralised at the NRC, we can expect that any new case of type F botulism that may occur in the future, will be identified and notified.…”

Section: Discussionmentioning

confidence: 99%

“…Food-borne botulism due to C. baratii type F is rare and only a limited number of cases have been reported worldwide [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

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A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

et al. 2016

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A cluster of three cases of food-borne botulism due to Clostridium baratii type F occurred in France in August 2015. All cases required respiratory assistance. Consumption of a Bolognese sauce at the same restaurant was the likely source of contamination. Clostridium baratii was isolated both from stool specimens from the three patients and ground meat used to prepare the sauce. This is the second episode reported in France caused by this rare pathogen.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

et al. 2016

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“…C. baratii is not taxonomically related to C. botulinum, but some members of this species have caused Microorganisms 2022, 10, 213 2 of 17 botulism outbreaks associated with food consumption, as well as sporadic infant botulism cases (less than 1% of total cases). These outbreaks are described as sporadic and rare episodes [11][12][13][14][15]; however, the strains that possess the neurotoxin may pose a significant threat, and it is essential to further study the properties of these microorganisms. C. baratii strains have been found in liver pastes, meat, soil, and other foods.…”

Section: Introductionmentioning

confidence: 99%

Comparative Genomics of Clostridium baratii Reveals Strain-Level Diversity in Toxin Abundance

2022

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Clostridium baratii strains are rare opportunistic pathogens associated with botulism intoxication. They have been isolated from foods, soil and be carried asymptomatically or cause botulism outbreaks. Is not taxonomically related to Clostridium botulinum, but some strains are equipped with BoNT/F7 cluster. Despite their relationship with diseases, our knowledge regarding the genomic features and phylogenetic characteristics is limited. We analyzed the pangenome of C. baratii to understand the diversity and genomic features of this species. We compared existing genomes in public databases, metagenomes, and one newly sequenced strain isolated from an asymptomatic subject. The pangenome was open, indicating it comprises genetically diverse organisms. The core genome contained 28.49% of the total genes of the pangenome. Profiling virulence factors confirmed the presence of phospholipase C in some strains, a toxin capable of disrupting eukaryotic cell membranes. Furthermore, the genomic analysis indicated significant horizontal gene transfer (HGT) events as defined by the presence of prophage genomes. Seven strains were equipped with BoNT/F7 cluster. The active site was conserved in all strains, identifying a missing 7-aa region upstream of the active site in C. baratii genomes. This analysis could be important to advance our knowledge regarding opportunistic clostridia and better understand their contribution to disease.

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“…but she recovered after 46 days in intensive care unit. The origin of this outbreak was not determined [139]. The second outbreak concerned three patients who have had their meal at the same restaurant on the same day.…”

Section: Foodborne Botulismmentioning

confidence: 99%

Botulinum Toxins, Diversity, Mode of Action, Epidemiology of Botulism in France

Popoff¹

2018

Botulinum Toxin

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Botulinum toxins (BoNTs) are the most potent toxins and are responsible for botulism, which is a neurological disease in man and animals. Botulism is characterized by flaccid paralysis and inhibition of secretions. BoNTs are produced by distinct clostridial species including Clostridium botulinum that consist in four physiological and genetic groups, atypical strains of C. baratii and C. butyricum. Recently, nonclostridial bacteria have been found to synthesize BoNTs. The particularity of BoNTs is to associate with nontoxic proteins to form large-size complexes that are resistant to acidic pH and protease degradation of the digestive tract. BoNTs are divided into 10 types based on neutralization by specific antisera and into more than 40 subtypes according to their sequence variations. All BoNTs retain a common core structure and mode of action, which consists in the inhibition of neurotransmitter release, notably acetylcholine. Human botulism occurs in three main forms: foodborne botulism, botulism by intestinal colonization including infant botulism, and wound botulism. In France, type B foodborne botulism is the most prevalent form, resulting from the traditional consumption of pork products such as home-made cured ham. Albeit less frequent, human botulism is still present in France including diverse types and origins.

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Cluster of two cases of botulism due to Clostridium baratii type F in France, November 2014

Cited by 12 publications

References 28 publications

A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

Comparative Genomics of Clostridium baratii Reveals Strain-Level Diversity in Toxin Abundance

Botulinum Toxins, Diversity, Mode of Action, Epidemiology of Botulism in France

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