Clustering of cancer in families of patients with primary lung cancer

McDuffie, Helen H.

doi:10.1016/0895-4356(91)90202-k

Cited by 64 publications

(45 citation statements)

References 14 publications

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“…The existence of genetic susceptibility to lung cancer is suggested in a number of familial aggregation studies [4][5][6]8,[15][16][17][18][19] as well as in segregation analyses [20][21][22][23][24] and in a linkage study 25 Familial risks may reflect not only genetic predisposition, but also shared exposures, such as smoking habits, [27][28][29] or exposure to cooking fumes. 7,30 To address this issue, we (i) included only relatives of never-smoking probands; (ii) took into account smoking habits of the relatives, both by controlling for smoking status and by conducting analyses stratified by smoking status.…”

Section: Discussionmentioning

confidence: 99%

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Gorlova

Weng

Zhang

et al. 2007

Intl Journal of Cancer

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The authors evaluated the familial aggregation of lung and other cancers in first-degree relatives of lung cancer patients selfreported to be lifetime never smokers. The data, derived from a large lung cancer case-control study, included 2,465 first-degree relatives of 316 never smoker lung cancer cases and 2,441 firstdegree relatives of 318 never smoker controls, frequency matched to the cases on age, gender and ethnicity. The median age of the cases and the controls was 61 years, about 2/3 were women, and about 80% were Caucasian. Overall, there was a 25% excess risk [95% CI (1.05-1.50)] of any type of cancer among the first-degree relatives of cases, and case offspring exhibited a 2-fold excess cancer risk (1.03-4.10) compared with control offspring. There was also a 44% excess risk ( Key words: lung cancer; familial aggregation; never smokers Lifetime never smokers with lung cancer likely represent a genetically susceptible subgroup distinct from ever smokers with lung cancer. 1 Familial aggregation may provide indirect evidence for a role of genetic factors in lung cancer susceptibility. The majority of studies that have evaluated familial aggregation in never-smoking lung cancer patients reported increased but not statistically significant lung cancer risk. [2][3][4][5][6][7][8][9] Several recent studies that analyzed aggregation of lung cancer in relatives of lung cancer patients reported no increased risk in first-degree relatives of never-smoking lung cancer cases. 8,9 However, one study suggested a significant 6-fold increased lung cancer risk in relatives of younger (40-59 years old) nonsmoking lung cancer patients, yet based on a small number of individuals (47 lung cancer cases and 50 controls). 3 Only a few studies have evaluated occurrence of other specific cancers in relatives of never-smoking lung cancer patients. 7,10,11 We estimated the risk of lung cancer and other cancers in firstdegree relatives of never-smoking lung cancer cases compared with first-degree relatives of matched controls, using self-reported data on family history derived from an ongoing lung cancer casecontrol study, controlling for relatives' smoking status as reported by the proband. Material and methods Subject recruitmentFrom September 1995 through December 2003, patients with lung cancer were accrued for an ongoing and previously described molecular epidemiological study on susceptibility markers for lung cancer from The University of Texas M. D. Anderson Cancer Center. 8,12,13 There were no age, gender, ethnic or stage restrictions. There were 316 patients with histologically confirmed lung cancer, who reported themselves to be lifetime never smokers (defined as those who had smoked less than 100 cigarettes in their lifetime). The response rate for cases was about 80%. The reasons for refusal to participate included patient too ill, patient referred only for second opinion to M. D. Anderson Cancer Center or patient unwilling to donate blood for the study and complete the interview. Healthy controls who were also lifeti...

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Section: Discussionmentioning

confidence: 99%

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Gorlova

Weng

Zhang

et al. 2007

Intl Journal of Cancer

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“…In all, 31 studies were identified that provided risks of lung cancer stratified by family history of the disease (Tokuhata and Lilienfeld, 1963a, b;Lynch et al, 1982;Ooi et al, 1986;Samet et al, 1986;Gao et al, 1987;Kramer et al, 1987;Sellers et al, 1987;Tsugane et al, 1987;Horwitz et al, 1988;Wu et al, 1988Wu et al, , 1996McDuffie et al, 1989;Wu-Williams et al, 1990;Liu et al, 1991;McDuffie, 1991;Osann, 1991;Shaw et al, 1991;Pavlakou et al, 1993;Schwartz et al, 1996Schwartz et al, , 1999Wang et al, 1996;Brownson et al, 1997;Kreuzer et al, 1998;Mayne et al, 1999;Bromen et al, 2000;Wunsch-Filho et al, 2002;Etzel et al, 2003;Wu et al, 2004;Jin et al, 2005;Matakidou et al, 2005). Three studies (Lynch et al, 1982;Sellers et al, 1987;Schwartz et al, 1999) were excluded from the review as the same data were duplicated in subsequent studies.…”

Section: Case -Control Studiesmentioning

confidence: 99%

Systematic review of the relationship between family history and lung cancer risk

2005

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We performed a systematic review of 28 case -control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case -control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.

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“…Tokuhata et al reported the first epidemiological evidence of a possible role of genetic factors in lung cancer development (Tokuhata et al, 1963). Other epidemiological studies showed that a risk for lung, or any cancer, is increased up to about five times in the relatives of lung cancer patients (Lynch et al, 1986;Ooi et al, 1986;Samet et al, 1986;Gao et al, 1987;Sellers et al, 1987;Tsugane et al, 1987;Horwitz et al, 1988;Wu et al, 1988;McDuffie et al, 1991;Osann, 1991;Shaw et al, 1991;Goldgar et al, 1994). Despite these studies, the underlying genetic mechanisms in familial clustering of malignancy remain to be disclosed.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports showed that an increased familial risk for any cancer including lung cancer was found among relatives of lung cancer probands (Lynch et al, 1986;Ooi et al, 1986;Samet et al, 1986; Gao et al, 1987;Sellers et al, 1987;Tsugane et al, 1987;Horwitz et al, 1988;Wu et al, 1988;McDuffie et al, 1991;Osann, 1991;Shaw et al, 199 1;Goldgar et al, 1994). Furthermore, an increased risk for cancer development was seen especially among relatives of female lung cancer probands and smoking acted synergistically with a family history of malignancy for tumorigenesis of female lung cancer (Osann, 1991).…”

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confidence: 99%

Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy

Suzuki

Ogura²,

Yokose³

et al. 1998

Br J Cancer

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Summary There is accumulating evidence of an increased risk of familial clustering of cancer in the first-degree relatives of lung cancer probands. However, no explanation has been proposed for these epidemiological data. We reviewed 379 female non-small-cell lung cancer (NSCLC) patients to obtain their family histories of malignancy. Among them, nine female NSCLC patients with three or more relatives diagnosed with malignancy and 28 control patients without a family history of malignancy were selected to be analysed for instability at six different microsatellite loci. We observed microsatellite instability (MSI) more frequently in the patients with three or more family histories of malignancy (six out of nine, 67%) than the control patients (5 out of 28, 18%). The incidence of MSI in the former was significantly higher than that in the control (P = 0.011: Fisher's exact test). We detected no significant difference in clinicopathological characteristics between the cases with MSI and those without MSI, except for their family histories of cancer. Our results show that a significantly higher rate of MSI is associated with familial clustering of malignancy. MSI could be one of the underlying mechanisms for familial clustering of malignancy in female NSCLC patients.

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Clustering of cancer in families of patients with primary lung cancer

Cited by 64 publications

References 14 publications

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Systematic review of the relationship between family history and lung cancer risk

Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy

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