CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodeficiency

Reddy, Sangeetha M.; Winston, Drew J.; Territo, Mary; Schiller, Gary J.

doi:10.1038/bmt.2010.35

Cited by 90 publications

(74 citation statements)

References 24 publications

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“…ganciclovir and foscarnet and emergence of drug-resistance. The development of CMV central nervous system disease in HSCTpatients is associated with several risk factors, including, among others, drug-resistance and high mortality despite therapy with a combination of anti-CMV drugs (ganciclovir, foscarnet and cidofovir) (Reddy et al, 2010). Suboptimal ganciclovir dose may promote the emergence of drug-resistance since adequate drug levels are crucial to control viral replication.…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient

et al. 2016

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“…We read with interest the article by Reddy et al 1 regarding central nervous system (CNS) CMV infection in SCT recipients and present two additional patients seen at Memorial Sloan-Kettering Cancer Center, including the imaging and histology findings.…”

mentioning

confidence: 99%

CMV encephalitis in BMT recipients

Sarva

Graber

Remanan

et al. 2011

Bone Marrow Transplant

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“…Table 2 describes, in detail, the main infections associated with solid organ transplantation patients 11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28 . 13,14,15,16,17,18 . Neurological manifestations include limbic encephalitis-like syndrome (HSV, CMV, HHV-6), rhombencephalitis, ventriculitis, myelitis, vascular involvement (VZV), and a multisystem posttransplant lymphoproliferative disorder (PTLD), which may involve the CNS and is associated with the EBV.…”

Section: Differential Diagnosis Of Infection In Solid Organ Causativementioning

confidence: 99%

“…Neurological manifestations include limbic encephalitis-like syndrome (HSV, CMV, HHV-6), rhombencephalitis, ventriculitis, myelitis, vascular involvement (VZV), and a multisystem posttransplant lymphoproliferative disorder (PTLD), which may involve the CNS and is associated with the EBV. 13,14,15,16,17,18 . Progressive multifocal leukoencephalopathy leads to demyelination after opportunistic infection of the JC virus 5 .…”

Section: Differential Diagnosis Of Infection In Solid Organ Causativementioning

confidence: 99%

Neurological complications of solid organ transplantation

Pedroso

Dutra

Braga‐Neto

et al. 2017

Arq. Neuro-Psiquiatr.

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Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the transplanted organ, and the intensity and type of immunosuppressive therapy. Neurological manifestations following solid organ transplantation pose a diagnostic challenge to medical specialists despite extensive investigation. This review aimed to provide a practical approach to help neurologists and clinicians assess and manage solid organ transplant patients presenting with acute or chronic neurological manifestations.Keywords: organ transplantation; neurological manifestations; central nervous system; peripheral nervous system. RESUMO O transplante de órgãos sólidos é um importante avanço no tratamento de doenças crônicas renal, hepática e cardíaca. Esta terapia tem aumentado a sobrevida e melhorado a qualidade de vida dos pacientes. Novas técnicas cirúrgicas e imunossupressores tem sido desenvolvidos para alcançar melhores desfechos. Entretanto, a variedade de complicações neurológicas que acompanham o transplante de órgãos sólidos é ampla, e carrega significado prognóstico. Pacientes podem ter acometimento do sistema nervoso central ou periférico devido a múltiplas causas que podem variar conforme o tempo após a realização da cirurgia, órgão transplantado e grau e tipo de terapia de imunossupressão. Manifestações neurológicas após o transplante de órgãos sólidos representam um desafio diagnóstico para médicos especialistas apesar de extensa investigação. O objetivo desta revisão é oferecer uma abordagem prática para ajudar neurologistas e clínicos a avaliar e manejar pacientes com transplante de órgãos sólidos que se apresentem com manifestações neurológicas agudas ou crônicas.Palavras-chave: transplante de órgãos; manifestações neurológicas; sistema nervoso central; sistema nervoso periférico.

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CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodeficiency

Cited by 90 publications

References 24 publications

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient

CMV encephalitis in BMT recipients

Neurological complications of solid organ transplantation

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