Cnidocyte Mechanoreceptors Are Tuned to the Movements of Swimming Prey by Chemoreceptors

Watson, Glen M.; Hessinger, David A.

doi:10.1126/science.2564698

Cited by 128 publications

(51 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Instead of a parallel evolutionary scenario, it is therefore possible that ciliary Hh signaling has evolved in an ancestral species as a consequence of an adaptive advantage of Hh-regulated chemosensation. Support for divergent evolution is that ORs as well as Smo-mediated Hh signaling are first found in the phylum Cnidaria, in species that have ciliated chemoreceptor cells (33)(34)(35). There is a striking evolutionary convergence toward a conserved organization of the peripheral olfactory pathways of insects and vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Hedgehog signaling regulates ciliary localization of mouse odorant receptors

Maurya

Bohm

Alenius

2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The ciliary localization of odorant receptors (ORs) is evolutionary conserved and essential for olfactory transduction. However, how the transport of ORs is regulated in mammalian olfactory sensory neurons is poorly understood. Here we demonstrate that odorant responsiveness and OR transport is regulated by the Hedgehog pathway. OR transport is inhibited by conditional gene inactivation of the Hedgehog signal mediator Smoothened (Smo) as well as by systemic administration of the Smo inhibitor vismodegib, a clinically used anticancer drug reported to distort smell perception in patients. The ciliary phenotype of Smo inhibition is haploinsufficient, cell autonomous, and correlates with the accumulation of OR-containing putative transport vesicles in the cytosol. The Smo-dependent OR transport route works in parallel with a low basal transport of vesicle containing both ORs and other olfactory transduction components. These findings both define a physiological function of Hedgehog signaling in olfaction and provide an important evolutionary link between olfaction and the requirement of a ciliary compartment for Hedgehog signaling.

show abstract

Section: Discussionmentioning

confidence: 99%

Hedgehog signaling regulates ciliary localization of mouse odorant receptors

Maurya

Bohm

Alenius

2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Moreover, Thorington & Hessinger (1988) demonstrated that the sea anemone Aiptasia pallida had 2 distinct chernoreceptors: one was specific for free or conjugated N-acetylated sugars, and the other exhibited broad specificity for low-molecular-weight amino compounds. Watson & Hessinger (1989) indicated that the sea anemone Haliplanella luciae had a rnechanoreceptor with a specific frequency at vibrations of 30, 55, 65 and 7 5 Hz. In the presence of chemical stimulants such as N-acetylated sugars and mucin, however, frequencies shifted to 5, 15, 30 and 40 Hz, which corresponded to the movements of swimming prey.…”

Section: Discussionmentioning

confidence: 99%

Chemoresponse of actinosporean spores of Myxobolus cultus to skin mucus of goldfish Carassius auratus

Yokoyama¹,

Ogawa²,

Wakabayashi³

1995

Dis. Aquat. Org.

View full text Add to dashboard Cite

Chemoresponse of actinosporean spores of Myxobolus cultus to goldfish mucus was studied and determination of the reactants was attempted. Reactiv~ty was counted as the percentage of empty actinosporean spores after mixing with the mucus The activity of mucus was lnaintained at -80°C but was n~ostly lost within 1 d at 5°C Heating at 30 to 80°C for 30 min did not affect the activity While neutral pH favored the reaction, strong a c~d and alkali decreased the reaction Phosphate buffer saline and sodlum chlonde solutions w t h inolanty >O 05 M inhibited the reaction A shnnkage of sporoplasms Inside the eplspore cavity caused by the high osmotic pressure was obseived Punficatlon of the reactants from goldfish mucus by gel filtration and ultrafiltrat~on revealed that they were lo~v-molecular-weight substances (c6000 h4W) Additionally, fish mucus from other flsh species (such as common carp Cyprinus carpio loach ~Misguinus angulll~cal~datus, r a~n b o w t~o u t Oncorhynchus mykiss, catfish Parasilurus asotus, and Japanese eel Anguilla japonica), as lvell as mucin from bovine submaxillary gland were slm~larly actlve It is suggested that actlnosporean spores I ecognlze fish hosts ~l t h low-molecular-xveight mucin components in skln mucus and that the portal of entry 1s the outer surface of flsh KEY WORDS: Myxosporean .

show abstract

“…Sea anemones employ hair bundle mechanoreceptors located on their tentacles to detect the swimming movements of planktonic prey (Watson and Hessinger 1989;Watson and Mire 2004). Hair bundle mechanoreceptors are derived from a multicellular complex in which two to four supporting cells surround a single sensory neuron (Fig.…”

Section: Introductionmentioning

confidence: 99%

The Involvement of Arl-5b in the Repair of Hair Cells in Sea Anemones

Watson

Graugnard

Mire

2007

JARO

Self Cite

View full text Add to dashboard Cite

The subcellular processes involved in repair of hair cells are not well understood. Sea anemones repair hair bundle mechanoreceptors on their tentacles after severe trauma caused by 1-h exposure to calcium-depleted seawater. Repair is dependent on the synthesis and secretion of large protein complexes named Brepair proteins.^A cDNA library on traumatized anemone tissue was probed using polyclonal antibodies raised to a specific chromatographic fraction of the repair protein mixture. An ADPribosylation factor-like protein, Arl-5b, was identified. The amino acid sequence of the Arl-5b protein in sea anemones is similar to that among several model vertebrates and humans. A polyclonal antibody raised to a peptide of the anemone Arl-5b labels some but not all hair bundles in healthy control animals. The abundance of labeled hair bundles significantly increases above healthy controls after trauma and continuing through the first hour of recovery. Dilute anti-Arl-5b blocks the spontaneous repair of hair bundle mechanoreceptors, suggesting that Arl-5b acts on the extracellular face of the plasma membrane. Immunoelectron microscopy indicates that Arl-5b is located along the length of stereocilia including sites in the vicinity of tip links. We propose that Arl-5b is involved in installing replacement linkages into damaged hair bundle mechanoreceptors.

show abstract

Cnidocyte Mechanoreceptors Are Tuned to the Movements of Swimming Prey by Chemoreceptors

Cited by 128 publications

References 16 publications

Hedgehog signaling regulates ciliary localization of mouse odorant receptors

Hedgehog signaling regulates ciliary localization of mouse odorant receptors

Chemoresponse of actinosporean spores of Myxobolus cultus to skin mucus of goldfish Carassius auratus

The Involvement of Arl-5b in the Repair of Hair Cells in Sea Anemones

Contact Info

Product

Resources

About