CNS activity of ZS-1A: a phytoceutical from &lt;i&gt;Zizyphus spina-christi&lt;/i&gt; root bark

Adzu, Bulus; Haruna, Abdurrashid; Ilyas, Mohammed; Gamaniel, K.

doi:10.4314/ijbcs.v2i4.39766

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…The fruits are applied on cuts and ulcers. They are also used to treat pulmonary ailments and fevers and to promote the healing of fresh wounds, for dysentery (Adzu et al, 2001). The leaves are applied locally to sores, and the roots are used to cure and prevent skin diseases (Adzu et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…They are also used to treat pulmonary ailments and fevers and to promote the healing of fresh wounds, for dysentery (Adzu et al, 2001). The leaves are applied locally to sores, and the roots are used to cure and prevent skin diseases (Adzu et al, 2001). The seeds are sedative and are taken sometime with buttermilk to halt nausea, vomiting and abdominal pains associated with pregnancy (Kaaria, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical analysis, proximate composition and antibacterial activities of Ziziphus Species (Z. jujube and Z. spina christi)

Alhassan¹,

Indabawa²,

Shah³

2019

jaar

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Despite tremendous progress in human medicines infectious diseases caused by bacteria, fungi, viruses and parasites are still a major threat to public health. Their impact is particularly large in developing countries due to relative unavailability of medicines and emergence of widespread drugs resistance.The aim and objectives of this research work was designed to carried outthe Phytochemical analysis, proximate composition and to evaluate the antimicrobial activities of the Ziziphus jujube and Ziziphus spina-christi leaves against clinical bacterial isolates (Escherichia coli, Staphloccoccus aureus and Klebsiella pneumoniae)as they were found out that since ancient times to date, they are used in treating various antimicrobial, ailment and disorders etc. The results of the research shows that, the effect of antibacterial activities of both aqueous and ethanolic extracts of Ziziphus jujube (e extract conc. aqueous; F=119.37, Bacterial extract conc. aqueous; F=1.00 and extract conc. ethanol; F=15.74, Bacterial extract conc. ethanol; F=0.59) are reciprocally proportional to their counterpart, Ziziphus spina-christi (extract conc. aqueous; F=54.96, Bacterial extract conc. aqueous; F=0.94 and extract conc. ethanol; F=81.11, Bacterial extract conc. ethanol; F=1.37). In sum, the minimum inhibitory concentration of Ziziphus jujube shows that the aqueous extract has MIC at range of 11.7 to 8.7mg/ml on all tested bacteria but the ethanolic extract has M.I.C of 14.8 to 8.2mg/ml range on E.coli, Klepsiellaspp and S. aureus. While, the minimum inhibitory concentration of Ziziphus spinachristi shows MIC of aqueous extract range of 12.8 to 8.3mg/ml on E. coli, Klepsiella spp and S.aureus. But, Ziziphus spinachristi MIC of ethanolic extract is 13.5 to 8.8mg/ml on all the tested bacteria. In sum, Zizuphus spina-christi has lower nutritional content and low MIC ethanolic extract than that of Ziziphus jujube.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis, proximate composition and antibacterial activities of Ziziphus Species (Z. jujube and Z. spina christi)

Alhassan¹,

Indabawa²,

Shah³

2019

jaar

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“…The aqueous root bark extract of Z. spina christi (25–100 ml/ kg) and the LD 50 of the fraction was 871.78 mg/kg for intraperitoneal were administered to the Swiss mice. This study revealed that doses (25, 50 and 100 mg/kg) were within the safe limit ( Adzu et al, 2009 ). A study was conducted to investigate the toxicity of six plants in the traditional Arab system of medicine.…”

Section: Toxicological Effectsmentioning

confidence: 67%

Genus Ziziphus for the treatment of chronic inflammatory diseases

Alsayari

Wahab

2021

Saudi Journal of Biological Sciences

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“…Ziziphus nummularia was not found to exhibit any behavioral changes or mortality in mice administered with aqueous-methanol Ziziphus nummularia leaf extract at oral doses of 3 and 5 g/kg, and up to 10 g/kg in a 24-h study, suggesting that Ziziphus nummularia is safe to use, and making it an attractive plant for natural drug discovery approaches [10]. In addition, toxicity analysis of other Ziziphus species concluded that they were safe [106,107]. Nonetheless, although toxicity studies indicate that Ziziphus nummularia extracts are nontoxic, there is still a need for further toxicology screening and particularly for long-term chronic toxicity studies to validate their safe usage.…”

Section: Toxicology Studiesmentioning

confidence: 99%

Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties

et al. 2022

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Ziziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: To gather the current knowledge related to the medicinal characteristics of Z. nummularia. Specifically, its phytochemical contents and pharmacological activities in the treatment of various diseases such as cancer, diabetes, and cardiovascular diseases, are discussed. Methods: Major scientific literature databases, including PubMed, Scopus, ScienceDirect, SciFinder, Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, Henriette′s Herbal Homepage, Dr. Duke′s Phytochemical and Ethnobotanical Databases, were searched to retrieve articles related to the review subject. General web searches using Google and Google scholar were also utilized. The search period covered articles published between 1980 and the end of October 2021.The search used the keywords ‘Ziziphus nummularia’, AND (‘phytochemical content’, ‘pharmacological properties, or activities, or effects, or roles’, ‘anti-inflammatory’, ‘anti-drought’, ‘anti-thermal’, ‘anthelmintic’, ‘antidiabetic’,’ anticancer’, ‘anticholinesterase’, ‘antimicrobial’, ‘sedative’, ‘antipyretic’, ‘analgesic’, or ‘gastrointestinal’). Results: This plant is rich in characteristic alkaloids, especially cyclopeptide alkaloids such as nummularine-M. Other phytochemicals, including flavonoids, saponins, glycosides, tannins, and phenolic compounds, are also present. These phytochemicals are responsible for the reported pharmacological properties of Z. nummularia, including anti-inflammatory, antioxidant, antimicrobial, anthelmintic, antidiabetic, anticancer, analgesic, and gastrointestinal activities. In addition, Z. nummularia has anti-drought and anti-thermal characteristics. Conclusion: Research into the phytochemical and pharmacological properties of Z. nummularia has demonstrated that this plant is a rich source of novel bioactive compounds. So far, Z. nummularia has shown a varied pharmacological profile (antioxidant, anticancer, anti-inflammatory, and cardioprotective), warranting further research to uncover the therapeutic potential of the bioactives of this plant. Taken together, Z. nummularia may represent a new potential target for the discovery of new drug leads.

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CNS activity of ZS-1A: a phytoceutical from <i>Zizyphus spina-christi</i> root bark

Cited by 5 publications

References 25 publications

Phytochemical analysis, proximate composition and antibacterial activities of Ziziphus Species (Z. jujube and Z. spina christi)

Phytochemical analysis, proximate composition and antibacterial activities of Ziziphus Species (Z. jujube and Z. spina christi)

Genus Ziziphus for the treatment of chronic inflammatory diseases

Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties

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