CNS depressant activities of Averrhoa carambola leaves extract in thiopental-sodium model of Swiss albino mice: implication for neuro-modulatory properties

Akter, Aklima; Islam, Fahadul; Bepary, Sristy; Al-Amin, Md.; Begh, Md. Zamshed Alam; Islam, Md. Al Fahad Ul; Ashraf, Ghulam Md; Baeesa, Saleh; Ullah, Mohammad Fahad

doi:10.1007/s11756-022-01057-z

Cited by 42 publications

(37 citation statements)

References 57 publications

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“…Over the next 50 years, it is anticipated that therapeutic intervention that can delay the onset or progression of AD would dramatically reduce the number of cases [ 18 ]. Natural products and their bioactive molecules have been widely shown as successful and promising sources of potential drug leads in the development of medications for the treatment of AD [ 19 , 20 ]. In this respect, mixtures or extracts of natural products contain natural bioactive molecules that could be a potential therapeutic strategy for treating or preventing AD [ 21 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Islam

Khadija

Harun-Or-Rashid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. AD is still the most prevalent form of dementia and affects many individuals across the globe. The exact cause of the disorder is obscure. There are yet no effective medications for halting, preventing, or curing AD’s progress. Plenty of natural products are isolated from several sources and analyzed in preclinical and clinical settings for neuroprotective effects in preventing and treating AD. In addition, natural products and their derivatives have been promising in treating and preventing AD. Natural bioactive compounds play an active modulatory role in the pathological molecular mechanisms of AD development. This review focuses on natural products from plant sources and their derivatives that have demonstrated neuroprotective activities and maybe promising to treat and prevent AD. In addition, this article summarizes the literature pertaining to natural products as agents in the treatment of AD. Rapid metabolism, nonspecific targeting, low solubility, lack of BBB permeability, and limited bioavailability are shortcomings of most bioactive molecules in treating AD. We can use nanotechnology and nanocarriers based on different types of approaches.

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Section: Introductionmentioning

confidence: 99%

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Islam

Khadija

Harun-Or-Rashid

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…The PI3K-Akt signaling pathway is also involved in the alleviation of depression, a condition that is more prevalent among postmenopausal women than among premenopausal ones [ 51 , 52 ]. Luteolin and quercetin, two key active flavonoid compounds in Yikunyin, have antidepressant activity [ 53 , 54 ], and thus, the natural Yikunyin prescription can potentially improve depression, one of the symptoms of menopausal syndrome. Previous studies that demonstrate the effect of menopause in increasing inflammation and IL-6 levels [ 38 ]suggest that the alleviation of excessive inflammatory response in menopausal women may have a positive effect on the treatment of menopausal atherosclerosis, a disease instigated by chronic inflammation [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Analysis of the Mechanism Underlying Yikunyin’s Therapeutic Effect on Menopausal Syndrome

Tan

Luo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Yikunyin is an empirical prescription that exhibits good efficacy in the clinical treatment of menopausal syndrome; however, its underlying mechanism remains unclear. This study investigates the mechanism implicated in the therapeutic effect of Yikunyin by identifying its hub genes, central pathways, and key active ingredients. Method. The active ingredients and targets of Yikunyin were obtained from the Traditional Chinese Medicine Systems Pharmacology database, whereas the targets related to menopausal syndrome were obtained from GeneCards, PharmGKB, Therapeutic Target Database (TTD), and Comparative Toxicogenomics Database (CTD). To reveal the pharmacological mechanism, the component-target and the intersecting protein-protein interaction (PPI) networks were constructed, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Finally, molecular docking was carried out to assess the strength of binding between the key active ingredients and key targets. Results. A total of 418 targets and 121 active ingredients were identified in Yikunyin. The intersection of Yikunyin’s 418 targets with the 2822 targets related to menopausal syndrome shows that there are 247 common targets that can be considered potential targets of Yikunyin in the treatment of menopausal syndrome. The topology analysis of the constructed PPI network conducted using the Cytoscape software shows that there are 15 hub genes implicated in the therapeutic effect of Yikunyin: AKT1, PRKCA, TLR9, CXCL10, PRKCD, PARP1, ABCB1, TP53, CAV1, MAPK8, PPARA, GRB2, EGFR, IL-6, and JAK2. Moreover, the key active components acting on these genes are paeoniflorin, luteolin, quercetin, beta-sitosterol, and kaempferol. GO and KEGG analyses indicate that Yikunyin can treat menopausal syndrome by regulating cellular response to chemical stress (GO:0062197), cellular response to oxidative stress (GO:0034599), phosphatase binding (GO:0019902), cytokine receptor binding (GO:0005126), PI3K-Akt signaling (hsa04151), lipid and atherosclerosis (hsa05417), and hepatitis B (hsa05161). Finally, the results of molecular docking suggest that the key active ingredients and key targets can bind well, with binding energies of less than −5 kJ/mol. Conclusion. The research conducted herein reveals that Yikunyin treats menopausal syndrome by targeting AKT1 and IL-6 and by regulating the PI3K-Akt signaling pathway. Moreover, it provides a new idea for understanding the therapeutic effects of traditional Chinese medicines.

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“…The substance reduces BrCa cell multiplication while enhancing the function of other drugs used for treatment. In BrCa cells from mice, HNK causes cell cycle arrest [ 135 , 136 ]. In MDA-MB-231 cells, it improves caspase 3 activation and stimulates pro-apoptotic features.…”

Section: Natural Compounds Against Breast Cancermentioning

confidence: 99%

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Islam

Nafady

et al. 2022

Molecules

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Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.

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CNS depressant activities of Averrhoa carambola leaves extract in thiopental-sodium model of Swiss albino mice: implication for neuro-modulatory properties

Cited by 42 publications

References 57 publications

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Network Pharmacology and Molecular Docking Analysis of the Mechanism Underlying Yikunyin’s Therapeutic Effect on Menopausal Syndrome

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

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