CNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring

Liang, Yu‐Xiang; Cheung, Siu Wun; Chan, Kevin C.; Wu, Ed X.; Tay, David; Ellis-Behnke, Rutledge

doi:10.1016/j.nano.2010.12.001

Cited by 36 publications

(17 citation statements)

References 20 publications

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“…In this system, the nanofibre scaffold was applied 105 days after optic tract transection, with MEMRI and behavioural assessments being performed in the 45 days following treatment. Sparse regeneration of optic tract fibres was visible in scaffold-treated animals on both MEMRI and histological imaging, 62 suggesting that the optic nerve maintains regenerative potential long after injury occurs. Notably, no functional recovery was observed following the nanoscaffold treatment.…”

Section: Neuroregenerationmentioning

confidence: 98%

Nanotechnology—novel therapeutics for CNS disorders

2012

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Research into treatments for diseases of the CNS has made impressive strides in the past few decades, but therapeutic options are limited for many patients with CNS disorders. Nanotechnology has emerged as an exciting and promising new means of treating neurological disease, with the potential to fundamentally change the way we approach CNS-targeted therapeutics. Molecules can be nanoengineered to cross the blood–brain barrier, target specific cell or signalling systems, respond to endogenous stimuli, or act as vehicles for gene delivery, or as a matrix to promote axon elongation and support cell survival. The wide variety of available nanotechnologies allows the selection of a nanoscale material with the characteristics best suited to the therapeutic challenges posed by an individual CNS disorder. In this Review, we describe recent advances in the development of nanotechnology for the treatment of neurological disorders—in particular, neurodegenerative disease and malignant brain tumours—and for the promotion of neuroregeneration.

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Section: Neuroregenerationmentioning

confidence: 98%

Nanotechnology—novel therapeutics for CNS disorders

2012

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“…For long-term treatment, hybrid scaffolds or SAPNS interact with the microenvironment conferring a biocompatible, biodegradable platform. Porosity, surface dimensions, and fibrous orientation contribute to positive material-cell interactions [reproduced with permission from Liang et al (2011)]. Bottom: the majority of peripheral nerve injuries are associated with severed neural regions, with limited axonal growth and myelination.…”

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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“…Moreover, peptide scaffold significantly reduced the apoptosis around the lesion site and effectively mitigated reactive gliosis and inflammation. When using noninvasive manganese enhanced magnetic resonance imaging (MEMRI) for real-time in vivo monitoring, Liang et al could observe that RADA was helpful to heal a chronic optic tract lesion and regenerate axons in CNS [105].…”

Section: Traditional Nanofiber Biomaterials For Cnsmentioning

confidence: 99%

Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

Liu

Wang

et al. 2014

Front. Mater. Sci.

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Central nervous system (CNS) presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanofiber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of selfassembling peptide nanofiber hydrogels for CNS regeneration.

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CNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring

Cited by 36 publications

References 20 publications

Nanotechnology—novel therapeutics for CNS disorders

Nanotechnology—novel therapeutics for CNS disorders

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

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