Co-administration of artemisinin and Ricinodendron heudelotii leaf extract—effects on selected antioxidants and liver parameters in male Wistar rats

Yakubu, Omolara Faith; Adebayo, Abiodun Humphrey; Okechukwu, Emeka S.; Adeyemi, Alaba Oladipupo; Iweala, E. E. J.; Zhang, Yingjun

doi:10.1007/s00580-018-2663-z

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Recently, we reported the antimicrobial effect of R. heudelotii extract [8] and the cytotoxic effect of isolated compounds from the leaf extract [9]. It was also reported that the leaf extract exhibited regulatory role on the toxicity of artemisinin when co-administered with artemisinin [10]. Reactive oxygen species (ROS) are generated as a result of oxidative processes in the body.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of fractions and compound from Ricinodendron heudelotii (Baill.)

Yakubu

Adebayo

Iweala

et al. 2019

Heliyon

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Medicinal plants have been documented over the years to play vital role in promoting human health. The study evaluated the anti-inflammatory and anti-oxidant activities of different fractions and isolated compound from Ricinodendron heudelotii leaves. The leaves of Ricinodendron heudelotii were extracted with ethanol and further partitioned sequentially using petroleum ether, ethylacetate and butanol. Bioassay–guided fractionation of the ethylacetate fraction was done using repeated column chromatographic technique while the structural elucidation of pure compound was carried out using mass spectra, 13C and 1H NMR analyses. Antioxidant potential of the fractions and isolated compound were evaluated with 2,2-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays and anti-inflammatory effect of fractions was measured by their inhibitory potency on nitric oxide (NO).Corilagin, an amorphous tannin was isolated and structurally elucidated. Corilagin showed scavenging effect against ABTS and DPPH radicals which vary in a dose dependent manner. It also showed an antioxidant potential with IC50 value of 0.003 mg/mL comparable to vitamin C 0.001 mg/mL) used as standard. The butanol and ethylacetate fractions exhibited significant (p < 0.05) NO inhibition of 60 and 69% respectively after treatment of RAW 264.7 macrophages with lipopolysaccharide. These results demonstrated the role of isolated corilagin as a promising potent antioxidant while the ethylacetate and butanol fractions suppressed the expression of an inflammation mediator by inhibiting nitric oxide.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of fractions and compound from Ricinodendron heudelotii (Baill.)

Yakubu

Adebayo

Iweala

et al. 2019

Heliyon

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“…Seven new tetracyclic triterpenoids ricinodols with potential as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors has also been reported to be isolated from R. heudelotii [9]. Yakubu et al [10] also reported the leaf extract to have regulatory effects on artemisinin toxicity when co-administered with artemisinin. This study aims to identify the chemical structure of isolated bioactive compounds in R. heudelotii as well as evaluate the compoundsfor in vitro cytotoxic activity against human leukemia (HL-60), human hepatocellular carcinoma (SMMC-7721), human lung adenocarcinoma (A549), human breast cancer cell (MCF-7), and colon adenocarcinoma (SW480) cell lines.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii

et al. 2019

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This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, 1H-NMR, and 13C-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,6-tri-O-galloyl glucose, and 4,6-di-O-galloyl glucose. Corilagin exhibited the most cytotoxic activity with an IC50 value of 33.18 μg/mL against MCF-7 cells, which were comparable to cisplatin with an IC50 value of 27.43 µg/mL. The result suggests that corilagin isolated from R. heudelotii has the potential to be developed as an effective therapeutic agent against the growth of breast cancer cells.

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Hypolipidemic effect of N-acetylcysteine against dexamethasone-induced hyperlipidemia in rats

Mada

Abarshi

Garba

et al. 2020

CJHS

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Objective: The liver is a key metabolic organ involved in lipid metabolism and maintenance of cholesterol homeostasis in the body. However, hypercholesterolemia and oxidative stress is associated with the fatty liver which is the major risk factor associated with cardiovascular diseases (CVDs). The objective of this study was to investigate the hypolipidemic property of N-acetylcysteine (NAC) in dexamethasone-induced hyperlipidemic rats. Materials and Methods: Dexamethasone (10 mg/kg) was administered on alternate days intraperitoneally for 28 days to induce hyperlipidemia. NAC (50 mg/kg and 100 mg/kg) was daily administered intraperitoneally for 28 days. After 24 h of the last treatment blood and liver samples were collected. Results: The relative body and liver weights, activities of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lipid profile, and antioxidant defense markers were measured. The result indicated that the treatment of hyperlipidemic rats with 50 and 100 mg/kg NAC significantly (P < 0.05) prevented dexamethasone-induced body weight loss and restored liver weight. In addition, NAC reduced the elevation of hepatic enzymes activities induced by dexamethasone. Moreover, NAC exhibits hypolipidemic effect as demonstrated by reversal of serum levels of total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and atherogenic index. Conclusion: These findings indicated that NAC was able to restore dyslipidemia induced by dexamethasone through improving liver function parameters and augments antioxidant defense systems. Altogether the anti- hyperlipidemic effects exhibited by NAC might have been mediated partly through antioxidant actions and could be beneficial against CVDs.

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Co-administration of artemisinin and Ricinodendron heudelotii leaf extract—effects on selected antioxidants and liver parameters in male Wistar rats

Cited by 3 publications

References 26 publications

Anti-inflammatory and antioxidant activities of fractions and compound from Ricinodendron heudelotii (Baill.)

Anti-inflammatory and antioxidant activities of fractions and compound from Ricinodendron heudelotii (Baill.)

Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii

Hypolipidemic effect of N-acetylcysteine against dexamethasone-induced hyperlipidemia in rats

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